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Biomedicines
Special Issues
Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies
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Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 525

Special Issue Editor

Dr. Deepti Diwan

E-Mail Website
Guest Editor
Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
Interests: cancer; stroke; epigenetics; molecular microbiology; genomics; nanobiotechnology; neurology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development and functionality of blood vessels play a pivotal role in various stages of growth, tissue repair, and disease progression. Diverse cell populations within the tissue microenvironment interact to facilitate the formation of blood vessels, ensuring tissue growth and homeostasis. Emerging evidence strongly suggests that the interplay between the nervous system and blood vessels holds a greater significance in understanding neurological diseases than previously acknowledged. Moreover, strategies focused on this neurovascular interplay present promising therapeutic opportunities for neurodegenerative disorders.

This Special Issue compiles reviews and recent research on neurovascular interactions in diverse pathological conditions. The novel findings are envisaged to advance our comprehension of the role of neurovascular dysfunction in various neurological conditions. Furthermore, future research is paramount in elucidating the clinical relevance and translational perspectives concerning the mechanisms underlying neurovascular dysfunction following an acute brain injury or neurological disorders, leveraging the potential of emerging high-end and rapidly evolving technologies.

Dr. Deepti Diwan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurovascular
  • blood vessels
  • nervous system
  • neurological diseases

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Published Papers (1 paper)

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10 pages, 1127 KiB  
Brief Report
Significant Microvascular Abnormalities Present in Autonomic Nervous System Dysfunction: Results of a Cross-Sectional Study
by Sehreen Mumtaz, Karissa Arca, Vikas Majithia, William Cheshire, David Hodge and Florentina Berianu
Biomedicines 2025, 13(5), 1242; https://doi.org/10.3390/biomedicines13051242 - 20 May 2025
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Abstract
Purpose: The prevalence and phenotype of capillaroscopic abnormalities in patients with autonomic nervous system dysfunction have not yet been investigated. Multiorgan involvement in dysautonomia entails abnormal vasoreactivity. We aim to correlate the diagnosis of autonomic dysfunction with certain clinical manifestations, which may provide [...] Read more.
Purpose: The prevalence and phenotype of capillaroscopic abnormalities in patients with autonomic nervous system dysfunction have not yet been investigated. Multiorgan involvement in dysautonomia entails abnormal vasoreactivity. We aim to correlate the diagnosis of autonomic dysfunction with certain clinical manifestations, which may provide prognostic or diagnostic information using a noninvasive technique, i.e., nailfold video capillaroscopy (NVC). Methods: Patients with autonomic nervous system dysfunction were recruited from rheumatology and neurology clinics with voluntary NVC procedures from 31 January 2024 to 10 January 2024, and a comparison with normal controls was performed. Additional recorded information include demographics and diagnoses of autonomic dysfunction types by autonomic testing, including, but not limited to, the following: reflex screen, sweat test, Valsalva maneuver, nerve fiber density, electromyography (EMG), serology, and history of autoimmune diseases. NVC was performed on a total of 27 patients. This study was approved by the Mayo Clinic Institutional Review Board. Results: The autonomic dysfunction group consisted of small-fiber neuropathy (37%), orthostatic hypotension (48%), autonomic neuropathy (30%), limited autonomic neuropathy (7%), postural orthostatic tachycardia syndrome (POTS) (7%), and connective tissue disease (7%), among other types. Patients with autonomic dysfunction had statistically significant increases in microhemorrhages, dilated capillaries, and ramifications when compared to controls. Conclusions: Autonomic dysfunction was associated with statistically significant microvascular abnormalities compared to normal controls with a distinct NVC pattern. There was a statistically significant correlation between age and BMI with microvascular abnormalities. Here, we demonstrate the diagnostic potential of NVC in autonomic dysfunction and advocate for further study of capillary structures in autonomic dysfunction. Full article
(This article belongs to the Special Issue Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies)
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