Molecular Mechanisms of Cardiovascular Diseases (CVDs)
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) remain the leading cause of global mortality and morbidity, imposing a significant societal and economic burden. While established risk factors like hypertension, dyslipidemia, and diabetes are well-recognized, a profound understanding of the molecular mechanisms driving disease pathogenesis is essential for developing novel diagnostics and targeted therapies. This Special Issue, titled "Molecular Mechanisms of Cardiovascular Diseases (CVDs)", seeks to compile cutting-edge research with a dedicated focus on dysregulated immunity, metabolic disturbances, and their critical interplay (immunometabolism) in CVD pathogenesis.
We invite original research and comprehensive reviews exploring how immune responses (e.g., inflammation, immune cell activation/infiltration, and cytokine signaling) and metabolic dysregulation (e.g., aberrant lipid/glucose metabolism, mitochondrial dysfunction, and metabolite signaling) individually or synergistically (via immunometabolism) drive the development and progression of CVDs, including atherosclerosis, heart failure, myocardial infarction, arrhythmias, and vascular dysfunction. The core interest of this Special Issue lies in elucidating immune–metabolic crosstalk within cardiovascular tissues. Key areas of interest include, but are not limited to, the following:
- Metabolic reprogramming of immune cells (e.g., macrophages and T cells) and its impact on CVD progression.
- Regulation of immune signaling pathways by metabolites (e.g., fatty acids, cholesterol, and ketone bodies).
- Role of metabolism-driven inflammation in endothelial dysfunction, myocardial injury, and fibrosis.
- Novel therapeutic strategies targeting the immune-metabolic axis.
This Special Issue aims to advance mechanistic insights into immune and metabolic dimensions of CVDs, ultimately accelerating the discovery of biomarkers and precision medicine interventions against these disorders.
We look forward to receiving your contributions.
Dr. Xiaoquan Rao
Guest Editor
Manuscript Submission Information
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Keywords
- cardiovascular diseases (CVDs)
- molecular mechanisms
- metabolic dysregulation
- immunity
- immunometabolism
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