Decoding Resistance: Molecular Drivers of Therapy Failure in Advanced Prostate Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 9
Special Issue Editor
Interests: cancer research; tumor microenvironment; therapeutics; molecular signaling; cellular biochemistry; cell death mechanism; cancer metastasis; metabolism; ciliary pathways; endocrinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
Castration-resistant prostate cancer (CRPC), particularly in its metastatic form (mCRPC), represents one of the most prevalent and lethal malignancies among men worldwide. Managing CRPC is challenging due to intrinsic or acquired resistance to therapy, driven by complex, multifactorial mechanisms that limit long-term treatment efficacy. The progression from hormone-sensitive prostate cancer (HSPC) to CRPC marks a pivotal clinical transition, underscored by resistance to androgen deprivation therapy (ADT) and the emergence of more aggressive, treatment-refractory phenotypes. Advances in molecular and immunological perspectives are rapidly reshaping the treatment landscape for mHSPC and mCRPC, underscoring the urgent need to unravel resistance mechanisms to develop more effective, personalized therapies. This Special Issue aims to highlight cutting-edge research elucidating the molecular and cellular mechanisms underpinning resistance to ADT, second-generation anti-androgens, radiotherapy, and novel targeted therapies. Emphasis will be placed on emerging concepts, including epigenetic remodeling, molecular signaling pathways, interactions between the tumor microenvironment and cancer, metabolic reprogramming, lineage plasticity, and the role of cancer stem-like cells. Additionally, the immunological dimensions of resistance and tumor evolution will be explored to provide a more comprehensive understanding of disease progression. We invite original research articles and reviews that offer novel insights into overcoming therapy resistance and improving outcomes for patients with advanced prostate cancer.
Dr. Jyoti Kaushal
Guest Editor
Manuscript Submission Information
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Keywords
- prostate cancer
- androgen deprivation therapy
- molecular signaling
- epigenetic remodeling
- cancer stem cell
- tumor microenvironment
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