Decoding Resistance: Molecular Drivers of Therapy Failure in Advanced Prostate Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 25
Special Issue Editor
Interests: cancer research; tumor microenvironment; therapeutics; molecular signaling; cellular biochemistry; cell death mechanism; cancer metastasis; metabolism; ciliary pathways; endocrinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
Castration-resistant prostate cancer (CRPC), particularly in its metastatic form (mCRPC), represents one of the most prevalent and lethal malignancies among men worldwide. Managing CRPC is challenging due to intrinsic or acquired resistance to therapy, driven by complex, multifactorial mechanisms that limit long-term treatment efficacy. The progression from hormone-sensitive prostate cancer (HSPC) to CRPC marks a pivotal clinical transition, underscored by resistance to androgen deprivation therapy (ADT) and the emergence of more aggressive, treatment-refractory phenotypes. Advances in molecular and immunological perspectives are rapidly reshaping the treatment landscape for mHSPC and mCRPC, underscoring the urgent need to unravel resistance mechanisms to develop more effective, personalized therapies. This Special Issue aims to highlight cutting-edge research elucidating the molecular and cellular mechanisms underpinning resistance to ADT, second-generation anti-androgens, radiotherapy, and novel targeted therapies. Emphasis will be placed on emerging concepts, including epigenetic remodeling, molecular signaling pathways, interactions between the tumor microenvironment and cancer, metabolic reprogramming, lineage plasticity, and the role of cancer stem-like cells. Additionally, the immunological dimensions of resistance and tumor evolution will be explored to provide a more comprehensive understanding of disease progression. We invite original research articles and reviews that offer novel insights into overcoming therapy resistance and improving outcomes for patients with advanced prostate cancer.
Dr. Jyoti Kaushal
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- prostate cancer
- androgen deprivation therapy
- molecular signaling
- epigenetic remodeling
- cancer stem cell
- tumor microenvironment
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
