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Biomedicines
Special Issues
Multisystem Crosstalk in Health and Disease
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Multisystem Crosstalk in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 4154

Editor

Dr. Mehmet Bostancıklıoğlu

E-Mail Website
Guest Editor
Departments of Endocrinology, Diabetes and Nutrition Center, Université Catholique de Louvain (UCLouvain), Brussels, Belgium
Interests: endocrinology; metabolic diseases; gut–brain axis; neuroscience; Alzheimer’s disease

Special Issue Information

Dear Colleagues,

Recent advances in biomedicine demonstrate that health and disease arise from dynamic crosstalk among multiple biological systems; however, substantial knowledge gaps remain in connecting these interactions across scales, from molecular pathways to whole-body physiology.

This Special Issue aims to integrate diverse research perspectives to advance a holistic understanding of health. We welcome submissions on foundational mechanisms, such as signaling networks bridging different systems, as well as translational studies identifying biomarkers and interventional strategies targeting multisystem interactions. In addition, we invite clinical investigations into how immune-metabolic dysregulation contributes to disease pathogenesis and novel therapeutic approaches. By illuminating the roles of systemic crosstalk, this issue seeks to uncover underexplored links and inspire innovative strategies that ultimately improve outcomes in chronic diseases and complex conditions.

Dr. Mehmet Bostancıklıoğlu
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • systems biology
  • immunometabolism
  • inflammation
  • integrative physiology
  • molecular pathways
  • translational research
  • multi-omics
  • chronic disease
  • host–microbe interactions
  • metabolic regulation

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Published Papers (1 paper)

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Research

17 pages, 574 KB  
Article
Early Postoperative C-Reactive Protein Trajectories After Thoracic Surgery: A Retrospective Cohort Study
by Ilker Kolbas, Berivan Karatekin, Esra Ergun Alış and Irfan Cicin
Biomedicines 2025, 13(10), 2532; https://doi.org/10.3390/biomedicines13102532 - 17 Oct 2025
Cited by 2 | Viewed by 3179
Abstract
Background: Distinguishing expected postoperative inflammation from early infection remains challenging after thoracic surgery; serial C-reactive protein (CRP) is widely used to aid this differentiation. Methods: We conducted a single-centre retrospective cohort study of adults undergoing thoracic surgery (1 January 2022–31 December 2024). CRP [...] Read more.
Background: Distinguishing expected postoperative inflammation from early infection remains challenging after thoracic surgery; serial C-reactive protein (CRP) is widely used to aid this differentiation. Methods: We conducted a single-centre retrospective cohort study of adults undergoing thoracic surgery (1 January 2022–31 December 2024). CRP was measured preoperatively and on postoperative days (POD) 1–5; trajectories were compared by surgical approach and extent of resection using repeated-measures ANOVA with Greenhouse–Geisser correction (α = 0.05). Results: Among 144 patients (VATS n = 79; open thoracotomy n = 65; extent: segmentectomy n = 25, lobectomy n = 96, bilobectomy n = 9, pneumonectomy n = 14), overall CRP rose from 26.6 ± 45.0 mg/L preoperatively to a POD2 peak of 200.9 ± 72.7 mg/L, then declined to 118.1 ± 70.7 mg/L by POD5. Thoracotomy showed higher peaks than VATS (POD2 216.1 ± 76.0 vs. 152.3 ± 29.9 mg/L; POD3 206.7 ± 88.7 vs. 159.8 ± 72.4 mg/L), but time × approach was not statistically significant (F = 1.042, p = 0.381; partial η2 = 0.115). The extent analysis showed the highest peaks with pneumonectomy (POD2 273.7 ± 46.3 mg/L) compared with bilobectomy (155.7 ± 11.0 mg/L) and lobectomy (VATS 132.1 ± 3.7, open 196.8 ± 85.3 mg/L); time × extent was not significant (F = 1.136, p = 0.384; partial η2 = 0.299). The overall effect of time did not reach significance (F = 1.127, p = 0.352; partial η2 = 0.124), reflecting variability. Patients with clinically diagnosed infections exhibited more prolonged CRP elevation, often >100 mg/L beyond POD4, whereas uncomplicated cases declined after the POD2 peak; these trends did not achieve statistical significance in this cohort. Conclusions: Early postoperative CRP in thoracic surgery typically peaks at 48–72 h and then falls. Higher peaks with open surgery and more extensive resection were observed but not statistically confirmed; persistence > 100 mg/L after POD3–4 may flag complications. Prospective studies are needed to validate thresholds and refine CRP-based surveillance pathways. Full article
(This article belongs to the Special Issue Multisystem Crosstalk in Health and Disease)
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