Multidisciplinary Approaches to Neurodegenerative Disorders

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 176

Special Issue Editor


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Guest Editor
1. Confido Medical Centre, Tallinn, Estonia
2. School of Natural Sciences and Health, Tallinn University, Tallinn, Estonia
Interests: neurodegenerative diseases; brain health preservation; Parkinson's disease; integrative medicine approaches; early detection and prevention

Special Issue Information

Dear Colleagues,

This Special Issue explores innovative multidisciplinary approaches to understanding, diagnosing, and treating neurodegenerative disorders. As these complex conditions continue to pose significant global health challenges, integration across disciplines has become essential for meaningful progress.

We welcome contributions bridging traditional boundaries between neuroscience, genetics, biomedical engineering, computational biology, and clinical medicine. The Special Issue seeks papers highlighting novel research methodologies, technological breakthroughs in early detection, therapeutic innovations, and emerging paradigms in disease modelling.

Key areas of interest include the following:

  • Comorbid conditions in neurodegenerative diseases—examining how multiple pathologies interact and influence disease progression.
  • Similarities and differences across neurodegenerative disorders—identifying common pathophysiological mechanisms and disease-specific features.
  • Connections between super-agers and lipid metabolism—exploring how lipid homeostasis relates to successful aging and neurodegeneration resistance.
  • Lipid metabolism alterations in neurodegenerative diseases—investigating metabolic dysfunction as both a cause and consequence of neurodegeneration.

Particular emphasis will be placed on translational research connecting fundamental molecular mechanisms to clinical applications, personalized medicine approaches, and cutting-edge interventions, including gene therapy, stem cell applications, and AI-driven diagnostic tools. We especially encourage submissions addressing how comorbidity patterns inform disease classification and treatment strategies, and how understanding metabolic signatures, particularly lipid profiles, can advance biomarker development and therapeutic targeting.

By showcasing diverse perspectives and collaborative frameworks, this Special Issue aims to catalyse new directions in neurodegenerative disease research and accelerate the development of effective interventions for conditions such as Alzheimer's, Parkinson's, ALS, and related disorders.

Prof. Dr. Toomas Toomsoo
Guest Editor

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Keywords

  • neurodegenerative disorders
  • lipid metabolism
  • comorbidity patterns super-agers
  • precision medicine
  • biomarker discovery
  • AI-assisted diagnostics
  • translational neuroscience
  • multi-omics integration
  • neuroinflammation

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Published Papers (1 paper)

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Review

17 pages, 703 KB  
Review
Neuroplasticity Across the Autism–Schizophrenia Continuum
by Evangelia Kesidou, Nikolaos Mitsoudis, Olympia Damianidou, Charilaos Taloumtzis, Marianna Tsakiridou, Eleni Polyzoidou, Eleni Grigoriadou, Christos Bakirtzis, Evangelia Spandou and Constantina Simeonidou
Biomedicines 2025, 13(11), 2695; https://doi.org/10.3390/biomedicines13112695 (registering DOI) - 2 Nov 2025
Abstract
Plasticity is a fundamental property of the brain that enables the nervous system to respond appropriately to internal and external stimuli. It primarily involves changes at the synaptic level, mediated by a wide array of molecules, ultimately leading to cognitive and behavioral changes. [...] Read more.
Plasticity is a fundamental property of the brain that enables the nervous system to respond appropriately to internal and external stimuli. It primarily involves changes at the synaptic level, mediated by a wide array of molecules, ultimately leading to cognitive and behavioral changes. This review critically contrasts the developmental timing and mechanisms of plasticity in Autism spectrum disorder (early hyperplasticity and excitation–inhibition imbalance) versus Schizophrenia (adolescent overpruning and NMDAR hypofunction) and evaluates evidence for interventions that harness plasticity to improve cognitive and behavioral outcomes. Preclinical and small clinical studies suggest that interventions targeting plasticity-related pathways may improve specific cognitive and behavioral domains. However, effects appear to be symptom-domain-specific and protocol-dependent and larger randomized controlled trials are needed to confirm efficacy. Cognitive remediation for Schizophrenia has been associated with improved executive function and increased hippocampal volume, while virtual reality-based training for Autism spectrum disorder has shown gains in attention and planning skills. By highlighting both molecular mechanisms and therapeutic strategies, this review aims to provide an integrated perspective on how plasticity-targeted interventions could be optimized across neurodevelopmental and neuropsychiatric disorders. Full article
(This article belongs to the Special Issue Multidisciplinary Approaches to Neurodegenerative Disorders)
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