Obesity-Related Gastrointestinal Disorders: Uncovering Mechanisms Behind Cardiometabolic Improvement with Weight Loss
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
Obesity and its associated cardiometabolic comorbidities remain significant drivers of chronic gastrointestinal (GI) diseases. Recent advances in the field of obesity, including anti-obesity medications (AOMs) and endoscopic/bariatric therapies, demonstrate the potential not only to reduce body weight but also to improve conditions such as type 2 diabetes, hypertension, gastro-esophageal reflux disease (GERD), and metabolic dysfunction-associated steatotic liver disease (MASLD). However, many aspects of how these procedures alter GI physiology and influence systemic metabolisms are still being uncovered.
For this Special Issue, we welcome submissions that elucidate the underlying mechanisms by which weight loss via different modalities (e.g., AOMs and endoscopic procedures) confers cardiometabolic benefits. We encourage articles that explore innovative techniques for weight management and improvements in cardiometabolic health, highlighting the role of gut hormones and investigating how these procedures modulate GI function in the context of broader metabolic health. By focusing on a range of methodological approaches—ranging from basic research to multidisciplinary collaborations—this Special Issue will advance our understanding of the complex relationships among obesity, chronic GI disease, and cardiometabolic risk. By providing a more comprehensive view of these interconnections, the Special Issue will facilitate the development of improved therapeutic strategies for patients with obesity-related GI disorders.
Dr. Wissam Ghusn
Guest Editor
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Keywords
- metabolic dysfunction-associated steatotic liver disease (MASLD)
- gastro-esophageal reflux disease (GERD)
- obesity
- cardiometabolic comorbidities
- type 2 diabetes
- hypertension
- gut hormones
- gastrointestinal function
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