Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Managing Hybridizing Populations: Threats or Opportunities for Conservation?
edited by and Marco Musiani
submission deadline 30 Nov 2025 | Viewed by 623 | Submission Open
Keywords: natural hybridization; anthropogenic hybridization; adaptive introgression; hybrid fitness; coexistence of wildlife and free-ranging domestic animals; management of hybridizing populations
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Exposure to Heavy Metals: Advances in Cytotoxicity and Genotoxicity
edited by Qianru Chi and Yi Zhao
submission deadline 30 Nov 2025 | Viewed by 387 | Submission Open
Keywords: heavy metal pollutants; exposure assessment; toxic mechanism; biomarkers; metabolomics; environmental quality monitoring; bioinformatics analysis methods
(This special issue belongs to the Section Toxicology)
Current Research in the Biodiversity, Ecology, and Evolution of Chondrichthyan Fishes (Sharks, Rays and Chimaeras)
edited by , and João Paulo Capretz Batista da Silva
submission deadline 30 Nov 2025 | Viewed by 277 | Submission Open
Keywords: Chondrichthyes; Elasmobranchii; Holocephali; sharks; skates; rays; chimaeras; chimaeras; biodiversity; taxonomy; systematics; ecology; evolution
(This special issue belongs to the Section Marine Biology)
Heavy Metal Pollution and Bioremediation: Application and Mechanism
edited by , Ruiyu Lin and Rongfei Wei
submission deadline 30 Nov 2025 | Viewed by 275 | Submission Open
Keywords: heavy metal pollutants; microbial remediation; phytoremediation; animal remediation; plant– soil– microbe interactions; enhanced remediation; combined remediation; hyperaccumulator plants; microbial-induced calcium carbonate precipitation
(This special issue belongs to the Section Toxicology)
Breast Cancer: Molecular and Cellular Mechanism and Biomarkers submission deadline 30 Nov 2025 | Viewed by 245 | Submission Open
Keywords: breast cancer; biomarkers; molecular mechanisms; multidrug resistance; personalized medicine; molecular targeted therapy; gene expression
(This special issue belongs to the Section Cancer Biology)
Exploring the Molecular Basis of Cancer: Perspectives from Genetics and Epigenetics
edited by
submission deadline 30 Nov 2025 | Viewed by 234 | Submission Open
Keywords: cancer genetics; epigenetics; tumor heterogeneity; histone modification; next-generation sequencing (NGS); cancer transcriptomics; gene regulation; mouse model; chromatin remodeling; CHIP-Seq; ATAC-seq; mutation; amplification
(This special issue belongs to the Section Genetics and Genomics)
Biological Foundations of Psychiatric Disorders
edited by Rammohan Shukla
submission deadline 30 Nov 2025 | Viewed by 188 | Submission Open
Keywords: psychiatric disorders; molecular mechanisms; animal models; therapeutic discovery; genetic associations; sex differences; protocols; methods; behavioral studies; stress-related phenotypes
(This special issue belongs to the Section Neuroscience)
Pathophysiology of Chronic Inflammatory Diseases
edited by Vincent Yuan
submission deadline 1 Dec 2025 | 3 articles | Viewed by 2141 | Submission Open
Keywords: chronic inflammation; autoimmune diseases; cytokines; inflammasome; metabolic dysfunction; oxidative stress; biomarkers; epigenetics; personalized medicine; therapeutic targets
(This special issue belongs to the Section Physiology)
Plant Epigenetics: Advancing Adaptation Strategies for Climate Change
edited by Qingzhu Zhang, and
submission deadline 1 Dec 2025 | 1 articles | Viewed by 916 | Submission Open
Keywords: mechanistic insights into epigenetic regulation; epigenetic memory and transgenerational inheritance; advances in epigenetic tools and techniques; epigenomics and phenotypic plasticity; implications for agriculture and conservation; tree epigenetic responses to climate change
(This special issue belongs to the Section Plant Science)
Global Fisheries Resources, Fisheries, and Carbon-Sink Fisheries submission deadline 15 Dec 2025 | 15 articles | Viewed by 10764 | Submission Open
Keywords: fisheries; habitats; overfishing; fishery resource biology; economic aquatic animal behavior; stock enhancement by releasing; environmental DNA; fisheries management; climate change; ecosystems; ecological models; carbon-sink; aquatic ecological ranches; fisheries products
Biogeochemical Element Cycling in Plant–Soil Systems: Implications for Ecosystem Dynamics and Services
edited by and Wajid Zaman
submission deadline 15 Dec 2025 | 5 articles | Viewed by 9806 | Submission Open
Keywords: autotrophs; biomass production; climate stabilization; ecosystem functions; ecosystem management; ecosystem policy; global change; heterotrophs; pollination; soil fertility; soil macro-organisms; soil micro-organisms
(This special issue belongs to the Section Ecology)
Environmental DNA (eDNA) for Assessment of Coastal Marine Biodiversity submission deadline 15 Dec 2025 | 1 articles | Viewed by 999 | Submission Open
Keywords: eDNA metabarcoding; coastal marine ecosystems; biodiversity; genetic distances; ecological indicators
(This special issue belongs to the Section Ecology)
Recent Advances in Understanding Systemic Lupus Erythematosus Pathogenesis
edited by Rohit Upadhyay
submission deadline 15 Dec 2025 | Viewed by 116 | Submission Open
Keywords: systemic lupus erythematosus (SLE); autoimmunity; immune dysregulation; B and T cell biology; interferon signaling; autoantibodies; epigenetics; biomarkers; therapeutic targets; systems immunology
(This special issue belongs to the Section Medical Biology)
Biology of Liver Diseases submission deadline 20 Dec 2025 | 3 articles | Viewed by 9645 | Submission Open
Keywords: viral hepatitis; alcoholic hepatitis; non-alcoholic steatohepatitis; autoimmune hepatitis; primary biliary cholangitis; liver cirrhosis; liver cancer; portal hypertension
(This special issue belongs to the Section Medical Biology)
Impacts of Climate Change on Terrestrial Carbon Cycling and Biodiversity Across Spatial and Temporal Scales submission deadline 21 Dec 2025 | 1 articles | Viewed by 692 | Submission Open
Keywords: climate change; terrestrial carbon cycling; biodiversity; spatial and temporal scales; ecosystem resilience; UN CBD; UN Decade on Ecosystem Restoration; responsible business; nature-based solutions; sustainable development
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Computational Modeling of Drug Delivery
edited by and Arezoo M. Ardekani
submission deadline 25 Dec 2025 | 2 articles | Viewed by 1622 | Submission Open
Keywords: computational modeling; drug delivery; computational fluid dynamics; biofluids; quantitative biotransport; mathematical models; artificial intelligence
(This special issue belongs to the Section Biophysics)
Experimental Biology 100 Years After the Foundation of the Italian Society: A Celebratory Special Issue submission deadline 31 Dec 2025 | 12 articles | Viewed by 29312 | Submission Open
Keywords: anatomy; histology; embryology; physiology; biochemistry; cell biology; genetics; pharmacology; anthropology; cancerology; pathology; microbiology; advanced microscopy and imaging; aging; aquatic environments; artificial intelligence applied to biomedicine; biodiversity and modeling; biology of reproduction and infertility; biomedical and pharmaceutical biotechnology; cellular stress; environment and health; micro- and nanovesicles in biomedicine; neuroscience; nutrition and food supplements; plant biology; precision medicine; regenerative medicine; structural biology; urban biodiversity and climate change
Physiology and Pathophysiology of Obesity
edited by Yifei Kang
submission deadline 31 Dec 2025 | 9 articles | Viewed by 23083 | Submission Open
Keywords: dietary intervention; alternative food; food supplementation; weight loss; weight management; obesity comorbidities; obesity pathophysiology
(This special issue belongs to the Section Physiology)
Adaptation of Living Species to Environmental Stress
edited by and Sonia Del Prete
submission deadline 31 Dec 2025 | 9 articles | Viewed by 20111 | Submission Open
Keywords: adaptation; environmental stress; evolutionary response; physiological adaptation; behavioral adaptation; morphological adaptation; climate change; conservation biology; biodiversity; ecological resilience; sound waves
(This special issue belongs to the Section Ecology)
Innovative Biotechnologies for Advancing Protein Function Investigation
edited by Yongjuan Zhao, Wanhua Li and Qiwen Deng
submission deadline 31 Dec 2025 | 6 articles | Viewed by 18889 | Submission Open
Keywords: protein imaging and visualization; high-throughput screening; computational methodologies; protein engineering; protein– protein interactions; protein– ligand interactions; biological mechanisms
(This special issue belongs to the Section Biotechnology)
Physiological, Biochemical, and Molecular Response in Plants under Light-Emitting Diode (LED) Treatment (Volume II) submission deadline 31 Dec 2025 | 7 articles | Viewed by 14094 | Submission Open
Keywords: antioxidants; bioactive compounds; biotic and abiotic stress; food quality; LED; nutrients; plant defense; plant response; productivity
(This special issue belongs to the Section Plant Science)
Animal Models in Toxicology
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 12817 | Submission Open
Keywords: animal model; biomarker of harm; pharmacokinetics; route of exposure; toxicology; toxin
(This special issue belongs to the Section Toxicology)
Nutrition, Environment, and Fish Physiology
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 11745 | Submission Open
Keywords: fish; physiology; nutrition; environment; effects   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Marine Biology)
Molecular Mechanisms of Plant Stress Adaptation
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 11390 | Submission Open
Keywords: plant adaptation; environmental stress; molecular mechanism; genetic improvement; stress tolerance
(This special issue belongs to the Section Plant Science)
Immune Microenvironment and Molecular Mechanism of Glioma
edited by Carolina Cristina Jancic
submission deadline 31 Dec 2025 | 3 articles | Viewed by 9574 | Submission Open
Keywords: gliomas; tumor microenvironment; immune response; tumor evasion; tumor resistance; immunotherapy TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Latin   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Latin to Simplified ChinesePRO Never translate Latin Never translate admin.mdpi.com
(This special issue belongs to the Section Cancer Biology)
Animal Models of Pancreatic Diseases
edited by Preeti Chhabra and Kenneth Brayman
submission deadline 31 Dec 2025 | 4 articles | Viewed by 9264 | Submission Open
Keywords: animal models; pancreatic diseases; pancreatitis; pancreatic cancer; diabetes; pathogenesis; therapeutic targets; preclinical testing
(This special issue belongs to the Section Physiology)
Differential Gene Expression and Coexpression (2nd Edition) submission deadline 31 Dec 2025 | 4 articles | Viewed by 8890 | Submission Open
Keywords: inflammation; cyclooxygenase 2; microsomal prostaglandin E synthase 1; cancer; epithelial mesenchymal transition; biomarkers; immunotherapy; metabolism; myeloid and lymphoid cells
(This special issue belongs to the Section Bioinformatics)
Recent Advances in Tumor Microenvironment Biology
edited by Hongbin Wang
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5728 | Submission Open
Keywords: tumor microenvironment; immune cells’ stromal cells; extracellular matrix; angiogenesis; metabolic reprogramming; tumor-associated macrophages; tumor-infiltrating lymphocytes; cytokine signaling; therapeutic targeting strategies  
(This special issue belongs to the Section Cancer Biology)
Stem Cells in Neurological Disorders: Challenges and Opportunities
edited by Ying Liu and Qi Lin Cao
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3804 | Submission Open
Keywords: stem cell research; neurological disorders; induced pluripotent stem cells (iPSCs); cell replacement therapy; gene editing in neurology; stem cell-derived exosomes; neuroregeneration; disease modeling; neuroprotective strategies; regenerative medicine
(This special issue belongs to the Section Neuroscience)
Epibiosis in Aquatic Environments submission deadline 31 Dec 2025 | 2 articles | Viewed by 3057 | Submission Open
Keywords: conservation; biodiversity; animals; aquatic environments; marine biology; marine zoology; marine ecology; radiation biology; interspecific interactions; evolution
Advances in Aquatic Ecological Disasters and Toxicology
edited by and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 2926 | Submission Open
Keywords: aquatic ecological disasters; aquatic toxicology; aquatic ecosystem; algal blooms; pollutants
Young Investigators in Biochemistry and Molecular Biology
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 2338 | Submission Open
Keywords: protein structure and function; DNA Methylation; apoptosis; computational biology; molecular development biology; molecular enzymology; molecular evolution; molecular immunology; molecular virology; systems biology; proteins and nucleic acids; protein trafficking; proteomics; structural and functional genomics; transcriptomics; signaling
(This special issue belongs to the Section Biochemistry and Molecular Biology)
The Potential of Genetics and Plant Breeding in Crop Improvement
edited by Jianyan Zeng, and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 2197 | Submission Open
Keywords: plants; plant signaling pathways; growth and development; genomics; transcriptomics; proteomics; metabolomics; gene transformation; molecular biology; biochemistry; molecular breeding; genome editing; CRISPR/Cas9; marker-assisted selection; genome-wide selection; crop improvement; genetic diversity; quality traits; yield; disease resistance; environmental stress; plant-microbe interactions; drought tolerance; salinity resistance; oxidative stress; phytohormone
(This special issue belongs to the Section Plant Science)
Feeding Biology and Nutrition in Insects
edited by and Christopher W. Weldon
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1928 | Submission Open
Keywords: diet; digestion; ecology; evolution; feeding; insects; mass-rearing; microbiome; nutrients; taste
(This special issue belongs to the Section Ecology)
Molecular Biology of Plants
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1821 | Submission Open
Keywords: transcriptome; metabolome; genome editing; genetic modification; stress resistance; yield improvement; secondary metabolites; flowering
(This special issue belongs to the Section Plant Science)
Large Animal Experimental and Epidemiological Models for Diseases submission deadline 31 Dec 2025 | 2 articles | Viewed by 1521 | Submission Open
Keywords: large animal model; dog; pig; ruminants; experimental study; epidemiological study; infectious diseases; non-infectious diseases; treatment; disease control; disease prediction
(This special issue belongs to the Section Medical Biology)
Responses and Resistance Mechanisms of Plants Under Environmental Stress
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1473 | Submission Open
Keywords: disease resistance; cold tolerance; defense priming; pathogen perception
(This special issue belongs to the Section Plant Science)
Sustainable Management of Aquatic Animal Health: Advances in Immunology, Pathogenesis, and Innovative Disease Control Strategies
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1363 | Submission Open
Keywords: aquatic animal health; immunology; pathogenesis; CRISPR-based innovations; sustainable aquaculture
(This special issue belongs to the Section Immunology)
Young Researchers in Plant Sciences
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1270 | Submission Open
Keywords: biodiversity; biogeography; biotic and abiotic stress responses; carbon sequestration; ecosystem functions; gene– function relationships; photosynthesis; phytohormones; phytoremediation; plant interactions with viruses; bacteria; fungi; plants; and animals; primary and secondary metabolism; seed development; signalling pathways; structure– function simulation modelling
(This special issue belongs to the Section Plant Science)
RNA Biology and mRNA in Diseases
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1260 | Submission Open
Keywords: stress granule; cRISPR/Cas13; vaccine; mRNA drug; antisense oligonucleotides; RNA methylation; microRNA; long non-coding RNA; RNA binding; RNA activation; circular RNA; fluorescent RNA; cell surface RNA; cancer; neurodegenerative disease
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Unveiling Novel Gene Functions: Mechanisms, Evolution and Applications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1180 | Submission Open
Keywords: Novel Gene Mechanisms; Molecular Pathways; Systems Biology; Moonlighting Genes; Adaptive Evolution; Synthetic Biology Applications
(This special issue belongs to the Section Genetics and Genomics)
The Application of Microorganisms and Plants in Soil Improvement submission deadline 31 Dec 2025 | 2 articles | Viewed by 1111 | Submission Open
Keywords: environmental microbiology; microbial diversity; microbial metabolism; nutrient transformation; plant growth promotion; rhizosphere effect; soil improvement
(This special issue belongs to the Section Microbiology)
Arthropods as Vectors of Human and Animal Pathogens: Vector Ecology and Disease Transmission
edited by Panpim Thongsripong
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1006 | Submission Open
Keywords: vector; disease ecology; vector-borne pathogens; mosquito; tick; flies; sandflies; triatomine; tsetse; fleas; mites
(This special issue belongs to the Section Infection Biology)
State of the Art in Fish Nutrition: Antimicrobials, Immunostimulants, Synbiotics and Alternative Protein Sources
edited by Jiun-Yan Loh
submission deadline 31 Dec 2025 | 1 articles | Viewed by 954 | Submission Open
Keywords: probiotics; prebiotics; synbiotics; immunostimulants; antimicrobial peptides; alternative protein/single-cell protein sources; insect meals; aquatic species; metabolisms; disease resistances
(This special issue belongs to the Section Zoology)
Living Resources of the Deep Sea: Biological Profiles and Environmental Linkages
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 869 | Submission Open
Keywords: deep-sea fisheries; spawning-ground shifts; habitat– environment coupling; rare deep-sea biodiversity; molecular adaptation; environmental DNA (eDNA); acoustic monitoring; fishery remote-sensing
(This special issue belongs to the Section Marine Biology)
Experimental Biology, Life Science and One Health: From Basic to Translational Research
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 849 | Submission Open
Keywords: anatomy; histology; embryology; aquatic environment and ecosystem; biotechnology and bioengineering; cell stress; environment and health; extracellular vesicles; fight against cancer; movement and nutrition science; neuroscience; plant ecology and ecosystem; regenerative biomedicine
Radiation and Biology: Investigating Cellular, Organismal, and Environmental Responses submission deadline 31 Dec 2025 | 1 articles | Viewed by 782 | Submission Open
Keywords: radiation-induced DNA damage and repair pathways; oxidative stress and redox signaling in radiation response; radiation-induced epigenetic modifications; radiation-induced immunomodulation and inflammation; radiation-induced carcinogenesis and disease susceptibility; ecological consequences of ionizing radiation
(This special issue belongs to the Section Medical Biology)
Deciphering the Biological Activity of Natural Compounds: Metabolic Control and Health Repercussions submission deadline 31 Dec 2025 | Viewed by 602 | Submission Open
Keywords: bioactive compounds; cytotoxic activity; pharmacology; enzyme inhibition; antioxidants; molecular mechanisms; anti-inflammatory activity; in vivo/vitro models; phytochemical analysis/evaluation
(This special issue belongs to the Section Plant Science)
Pathobiology of Cardiac Arrhythmias and Heart Failure Issues
edited by Mohit Hulsurkar
submission deadline 31 Dec 2025 | 1 articles | Viewed by 490 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; heart failure; ion channelopathy; cardiac fibrosis; cardiomyopathy
(This special issue belongs to the Section Physiology)
Young Researchers in Immunology
edited by and Moses New-Aaron
submission deadline 31 Dec 2025 | Viewed by 482 | Submission Open
(This special issue belongs to the Section Immunology)
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