The Role of Lipids in Cardiovascular and Neurodegenerative Diseases

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 378

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
Interests: metabolomics; lipidomics; analytical chemistry
1. School of Liquor and Food Engineering, Guizhou University, Huixia, Guiyang 550025, China
2. National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Medicine and Food, Guizhou University, Guiyang 550025, China
Interests: metabolomics; food safety; health; lipidomics

E-Mail Website
Guest Editor
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA
Interests: metabolomics; in vitro diagnostics; preeclampsia

Special Issue Information

Dear Colleagues,

Lipid molecules, including glycerolipids, glycerophospholipids, sterol lipids, and other classes, are fundamental for both physiological processes and disease mechanisms. In cardiovascular diseases, dysregulated lipid metabolism is a key driver of atherosclerosis, leading to conditions such as heart attacks and strokes. The balance between LDL and HDL cholesterol, along with the inflammatory responses triggered by lipid accumulation, highlights the complexity of lipid involvement in cardiovascular health.

Similarly, in neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease, lipids play crucial roles in maintaining neuronal structure and function. Dysregulation of lipid homeostasis, particularly involving cholesterol and lipid rafts, contributes to the formation of pathological aggregates, neuroinflammation, and oxidative stress, accelerating neuronal damage and disease development.

This Special Issue gathers the latest research on the roles of lipid molecules in these diseases, offering insights into the underlying mechanisms and potential therapeutic targets. By exploring the intersections between lipid biology, cardiovascular science, and neurodegeneration, we aim to foster a deeper understanding of lipid biology and inspire new strategies for the prevention and treatment of these diseases.

 In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: lipid biology, lipid peroxidation, lipidomics, lipid foods or nutrients, cardiovascular disease, and neurodegenerative diseases.

We look forward to receiving your contributions.

Dr. Yuanyuan Ji
Dr. Ronghui Gu
Dr. Yaxin Li
Guest Editors

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Keywords

  • lipid biology
  • lipid peroxidation
  • lipidomics
  • lipid foods or nutrients
  • cardiovascular disease
  • neurodegenerative diseases

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Published Papers (1 paper)

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Review

19 pages, 1959 KiB  
Review
Role of High-Fat Diet Alone on Lipids, Arterial Wall and Hippocampal Neural Cell Alterations in Animal Models and Their Implications for Humans
by Gayathri S. Prabhu, Mohandas Rao KG, Preethi Lavina Concessao and Kiranmai S. Rai
Biology 2025, 14(8), 971; https://doi.org/10.3390/biology14080971 (registering DOI) - 1 Aug 2025
Abstract
Background: A high-fat diet has been shown to have an impact on metabolism resulting in changes in arterial wall thickness and degeneration of surviving neural cells of the hippocampus. The present review focuses on the various animal models used to induce high-fat diet [...] Read more.
Background: A high-fat diet has been shown to have an impact on metabolism resulting in changes in arterial wall thickness and degeneration of surviving neural cells of the hippocampus. The present review focuses on the various animal models used to induce high-fat diet conditions for studying obesity-induced atherosclerosis, along with the associated changes observed in surviving neural cells of the hippocampus. It also highlights the limitations of rodent models and discusses their implications for human research. Methods: The sources for the literature search were Scopus, PubMed, Medline and Google Scholar. Both animal and human studies published were considered and are cited. Results: High-fat-diet-induced vascular changes, mainly in the tunica media, has been shown to have more impact on medium-sized arteries and on the Cornu Ammonis three subregions and outer dentatae gyrus of the hippocampus. Conclusions: High-fat-diet-induced neurovascular changes have been studied radically in animal models, and more supporting studies representing preclinical research should be advanced to humans. Full article
(This article belongs to the Special Issue The Role of Lipids in Cardiovascular and Neurodegenerative Diseases)
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