Pluripotent Stem Cells in Development and Disease
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Developmental and Reproductive Biology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 68
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), possess the unique ability to differentiate into most cell types, making them invaluable tools in studying early development, modelling diseases, and developing novel therapies.
This Special Issue will explore the transformative role of PSCs in mechanistic studies and regenerative medicine. It will highlight the use of PSCs to unravel the molecular and cellular mechanisms underlying developmental processes, such as cell fate determination and tissue formation. A significant portion of this Special Issue will be dedicated to the application of PSCs in disease modelling, particularly for complex disorders such as neurodegenerative diseases, cardiovascular conditions, and cancer. Ways in which PSC-derived organoids and tissue models provide novel insights into disease pathology and drug screening will also be discussed.
This Special Issue will also address challenges in the field, such as improving differentiation protocols, ensuring genomic stability. Emerging technologies, including CRISPR-Cas9 gene editing and single-cell omics and synthetic embryos using PSCs, will be showcased as powerful tools enhancing the precision and utility of PSC research.
Overall, this Special Issue will underscore the potential of PSCs to revolutionize our understanding of human development and disease. It will serve as a useful resource for researchers and clinicians who are interested in the cutting-edge applications of PSCs in biomedicine.
We look forward to receiving your contributions.
Dr. Qiang Wu
Guest Editor
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Keywords
- pluripotent stem cells (PSCs)
- early development
- regenerative medicine
- genetic/epigenetic factors
- differentiation
- cell fate determination
- disease modelling
- organoids
- genomic editing
- single-cell omics
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