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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bone Mechanics: From Cells to Organs, to Function

edited by

Viviana Toro-Ibacache

submission deadline 31 Aug 2026 | 1 articles | Viewed by 799 | Submission Open

Keywords: bone mechanics; bone remodeling; mechanotransduction; structural analysis; functional morphology; bioengineering

(This special issue belongs to the Section Physiology)

Microbiology and Metabolomics in Reproductive Biology

edited by

Giuseppina Campisciano

submission deadline 31 Aug 2026 | Viewed by 375 | Submission Open

Keywords: maternal microbiome; metabolome; pregnancy outcomes; fetal development; biomarkers; immune function; metabolic health; disease prediction; therapeutic interventions; maternal and child health

(This special issue belongs to the Section Developmental and Reproductive Biology)

Sickle Cell Disease: Molecular Mechanisms, Pathogenesis and Therapies

edited by Chithra Palani

submission deadline 31 Aug 2026 | Viewed by 369 | Submission Open

Keywords: SCD; anemia; erythrocyte development; erythroid progenitors; CD34 cells; vaso-occlusion; pain crisis; hemolysis; oxidative stress; sickling; inflammation; ER stress; fetal hemoglobin; hematopoiesis; ischemia and tissue damage; organ damage; drug development; SCD diagnosis; gene therapy; cell therapy

(This special issue belongs to the Section Medical Biology)

Energy Metabolism, Genetics and Development in Drosophila

edited by

Do-Hwan Lim

submission deadline 31 Aug 2026 | 1 articles | Viewed by 367 | Submission Open

Keywords: Drosophila; energy metabolism; development; epigenetics; non-coding RNAs; metabolic disease; growth; signaling pathway

(This special issue belongs to the Section Bioinformatics)

Fruits and Seeds of Tropical Plants: Conservation of Species, Ecological Importance and Quality Valorization

edited by Edna Ursulino Alves and Silvanda De Melo Silva

submission deadline 31 Aug 2026 | 1 articles | Viewed by 347 | Submission Open

Keywords: climate change; nature conservation; biodiversity; plant propagation; postharvest quality; metabolic profile; orchard management and quality

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Advances in Cardiac and Vascular Biology: From Mechanisms to Pathophysiology

edited by

Hanqiang Deng

and

Haodi Wu

submission deadline 31 Aug 2026 | Viewed by 274 | Submission Open

Keywords: cardiovascular biology; molecular mechanisms; cellular signaling; epigenomic regulation; vascular remodeling; metabolic reprogramming; cardiac pathophysiology

(This special issue belongs to the Section Physiology)

Biophysics of Exposome: Molecular Mechanisms of Action

edited by

Judith Klein-Seetharaman

and Madhavi K. Ganapathiraju

submission deadline 31 Aug 2026 | Viewed by 180 | Submission Open

Keywords: computational biology; systems biology; mass spectrometry; protein– ligand networks; protein– protein interaction networks; metabolomics; proteomics; surface plasmon resonance; protein structure prediction; molecular docking; target fishing; machine learning; artificial intelligence

Current Status and Future Perspectives on Lipid Biology and Beyond

edited by

Jasmina Debeljak Martacic

and

Slavica Ranković

submission deadline 31 Aug 2026 | Viewed by 171 | Submission Open

Keywords: lipids; fatty acids (FAs); omega-3 (FA); omega-6 (FA); cancer; cell biology; oxylipins; oxidative stress; lipidomics; lipid nanoparticles; personalized lipid-based therapies

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Mitochondrial Genomics of Arthropods

edited by Renfu Shao

submission deadline 31 Aug 2026 | Viewed by 110 | Submission Open

Keywords: mitochondrial genome architecture; transcriptional dynamics; translational mechanisms; comparative genomics; molecular evolution; arthropod phylogenetics; systematics; evolutionary biology

(This special issue belongs to the Section Genetics and Genomics)

Research Progress on Metabolic Pathways in Neurodegenerative Diseases

edited by Ali H. Rafati

submission deadline 31 Aug 2026 | Viewed by 104 | Submission Open

Keywords: neurodegeneration; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; autophagy; neuroinflammation; biomarkers; therapeutic targets

(This special issue belongs to the Section Neuroscience)

Novel Mechanisms and Biological Processes in Redox and Inflammatory Signaling

edited by Shengchen Wang and

Demin Cai

submission deadline 31 Aug 2026 | Viewed by 77 | Submission Open

Keywords: redox; inflammatory; oxidative stress; antioxidant; anti-inflammatory; signaling pathways

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Biogenesis and Function of Centrioles, Centrosomes, and Primary Cilia in Health and Disease

edited by

Ramona Lattao

and

Hélène Rangone

submission deadline 31 Aug 2026 | Viewed by 65 | Submission Open

Keywords: centriole; centrosome; cilia

(This special issue belongs to the Section Cell Biology)

Biological Invasions in Freshwater Ecosystems

edited by Filipe Banha

submission deadline 31 Aug 2026 | Viewed by 50 | Submission Open

Keywords: invasive species; rivers; lakes; ecology; biology; impacts

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Uncovering the Role of T Cells in Immune Homeostasis and Immune Tolerance

edited by

Yohei Sato

submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open

Keywords: regulatory T cells; immune tolerance; FOXP3; cytokine; suppression

(This special issue belongs to the Section Cell Biology)

Biosynthesis of Metabolites from Microorganisms, or Microorganism-Host Interaction? (Volume II)

edited by

Fengli Zhang

Zhiqiang Liu

and

Michel Denis

submission deadline 1 Sep 2026 | 6 articles | Viewed by 18179 | Submission Open

Keywords: biosynthesis; biological activity; biosynthesis regulation; microbial metabolites; microbe– host reaction

(This special issue belongs to the Section Microbiology)

Viral Infections in Animals: Pathogenesis and Immunity

edited by

Yang Li

submission deadline 1 Sep 2026 | 1 articles | Viewed by 1785 | Submission Open

Keywords: virus– host interactions; antiviral immunity; mechanisms of viral pathogenesis

(This special issue belongs to the Section Immunology)

Latest Discoveries in Non-Model Organisms and Non-Translational Biology

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 8 Sep 2026 | Viewed by 161 | Submission Open

Keywords: basic biological research; non-translational biology; non-clinical biology; fundamental science; non-model organisms; model organisms; scientific curiosity– driven research; biological diversity; experimental biology; theoretical biology

Feature Papers on Developmental and Reproductive Biology

edited by

Jacek Z. Kubiak

submission deadline 15 Sep 2026 | 11 articles | Viewed by 28557 | Submission Open

Keywords: embryo/fetus development; reproductive biology; gametogenesis; differentiation; growth; homeostasis; regeneration; aging; cell cycle regulation; stem cells; organoids

(This special issue belongs to the Section Developmental and Reproductive Biology)

Molecular and Cellular Mechanisms of Neuroinflammation and Chronic Pain

edited by Mario Garcia-Dominguez

submission deadline 15 Sep 2026 | Viewed by 51 | Submission Open

Keywords: neuroinflammation; chronic pain; neuroimmune interactions; glial activation; cytokine signaling; synaptic plasticity; oxidative stress; epigenetic regulation; microglia and astrocytes; therapeutic targets

(This special issue belongs to the Section Neuroscience)

Plant Breeding: From Biology to Biotechnology

edited by Juwu Gong

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8561 | Submission Open

Keywords: plant breeding; biotechnology; molecular marker-assisted selection; genetic engineering; genome editing; tissue culture; phenotype; genetics; omics

(This special issue belongs to the Section Biotechnology)

Signalling Pathways in Cancer and Disease

edited by

Ahmed Elbediwy

and

Nadine Wehida

submission deadline 30 Sep 2026 | 5 articles | Viewed by 6258 | Submission Open

Keywords: cancer; signalling; metastasis; tumorigenesis; cancer targeting

(This special issue belongs to the Section Cancer Biology)

Molecular Basis of Bone Homeostasis and Skeletal Diseases

edited by

Weirong Xing

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5615 | Submission Open

Keywords: osteoclast; osteoblast; bone; skeletal disease; bone formation; bone resorption; osteoporosis; osteopetrosis; human genetics; mouse genetics

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Large Animal Experimental and Epidemiological Models for Diseases

edited by

Witaya Suriyasathaporn

and

Sho Nakamura

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5025 | Submission Open

Keywords: large animal model; dog; pig; ruminants; experimental study; epidemiological study; infectious diseases; non-infectious diseases; treatment; disease control; disease prediction

(This special issue belongs to the Section Medical Biology)

Research Advancements in Oral Biology

edited by

Jelena R. Roganović

and Nina Petrović

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4089 | Submission Open

Keywords: oral biology; oral tissue regeneration; artificial intelligence (AI) in dentistry; genomics and proteomics in dentistry; dental research; salivary diagnostics

(This special issue belongs to the Section Medical Biology)

The Role of Innate Immunity in Organ Transplantation

edited by Todd V. Brennan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1776 | Submission Open

Keywords: innate immunity; allograft rejection; transplantation; immune tolerance

(This special issue belongs to the Section Medical Biology)

Molecular Mechanisms of Cell Signal Transduction

edited by

Wenjing Zhang

submission deadline 30 Sep 2026 | Viewed by 509 | Submission Open

Keywords: molecular interactions in signaling; phosphorylation and signal propagation; post-translational modifications; cross-talk between signaling pathways; cellular response to extracellular stimuli; metabolic regulation and signaling; signaling in cancer progression; inflammatory signaling pathways; role of signaling in stem cell differentiation; innovative imaging techniques for signaling

(This special issue belongs to the Section Cell Biology)

Physiology and Ecology of Animal Parasites and Related Diseases

edited by Marcela K. Castelo

submission deadline 30 Sep 2026 | Viewed by 425 | Submission Open

Keywords: parasites; parasitoids; physiology; ecology; ecophysiology; diseases; global change

(This special issue belongs to the Section Zoology)

More than a Shield: The Secret Functions of Epithelial Cells in Homeostasis and Infections

edited by

Mohamed Ibrahem Elhawy

and Na Zhao

submission deadline 30 Sep 2026 | Viewed by 256 | Submission Open

Keywords: epithelial diversity; signaling; homeostasis; immunity; infection; microbiome; inflammation; cytokines; antimicrobial peptides

(This special issue belongs to the Section Medical Biology)

Bone Physiology and Development

edited by

Silviya Nikolova

Diana Toneva

and Yohei Abe

submission deadline 30 Sep 2026 | Viewed by 122 | Submission Open

Keywords: osteology; osteogenesis; bone growth; bone physiology; bone morphology; bone pathology; bone imaging

(This special issue belongs to the Section Physiology)

Gut Microbiome in Health and Disease (3rd Edition)

edited by

Hao Zhong

and

Fengqin Feng

submission deadline 30 Sep 2026 | Viewed by 122 | Submission Open

Keywords: gut microbiota; ‘ gut– X’ axis; dysbiosis; food nutrition; metabolites; type 2 diabetes mellitus; gut health; immunity

(This special issue belongs to the Section Microbiology)

Molecular Mechanisms of Retina Development and Degeneration

edited by

Hélène Léger

submission deadline 30 Sep 2026 | Viewed by 106 | Submission Open

Keywords: retina; retinal development; retinal degeneration; molecular mechanisms; signaling pathways; genetic regulation; epigenetics; neuronal and glial interactions; neuroinflammation

(This special issue belongs to the Section Biochemistry and Molecular Biology)

The Molecular and Cellular Mechanisms of Lung Injury and Recovery

edited by Weiguo Chen, HongLong Ji and Ibra S. Fancher

submission deadline 30 Sep 2026 | Viewed by 103 | Submission Open

Keywords: acute lung injury; chronic lung injury; ARDS; fibrosis; allergy; mechanisms; therapy; infection; inflammation; endothelial barrier

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Innovative Approaches to Rice Crop Production Under Environmental Stresses

edited by

Chanakan Prom-u-thai

submission deadline 30 Sep 2026 | Viewed by 65 | Submission Open

Keywords: abiotic stress; environmental stress response; stress adaptation; DNA damage and repair; functional genomics; plant physiology; biofortification

(This special issue belongs to the Section Genetics and Genomics)

Pathogenic Mechanisms Involved in Development and Progression of ROS-Associated Diseases

edited by

Hye-Jin Park

submission deadline 30 Sep 2026 | Viewed by 61 | Submission Open

Keywords: Reactive Oxygen Species (ROS); oxidative stress; pathogenic mechanisms; disease progression; mitochondrial dysfunction; inflammation and immune regulation; redox biology; molecular signaling pathways; antioxidants and therapeutics; comparative medicine; One Health; translational research

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Antibiotic Resistance Mechanisms: Ecological Implications

edited by

Fernando Baquero

submission deadline 30 Sep 2026 | Viewed by 50 | Submission Open

Keywords: antibiotic resistance in environmental bacteria; antibiotics in the environment; ecological consequences of antibiotic resistance; antibiotic synergies and antagonisms with environmental pollutants; biomarkers of antibiotic resistance in the environment

(This special issue belongs to the Section Microbiology)

Genetics and Epigenetics of Neurological Disorders

edited by

Milena Janković

submission deadline 30 Sep 2026 | Viewed by 36 | Submission Open

Keywords: neurological disorders; neurogenetics; genomics; epigenomics; DNA methylation; precision medicine

(This special issue belongs to the Section Neuroscience)

Ecological Interactions and Adaptive Strategies in Wildlife

edited by

Motti Charter

submission deadline 30 Sep 2026 | Viewed by 33 | Submission Open

Keywords: biological pest control; predator– prey dynamics; avian reproductive ecology; evolutionary traits; human– wildlife coexistence; invasive species impacts; artificial nest ecology; ecosystem

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Coral Physiological Plasticity and Environmental Adaptation: From Molecular Mechanisms to Ecosystem Resilience

edited by

Jennifer L. Matthews

submission deadline 30 Sep 2026 | Viewed by 29 | Submission Open

Keywords: environmental stressors; physiological plasticity; climate resilience; molecular mechanisms; coral symbiosis; adaptive potential; ocean acidification; thermal tolerance

(This special issue belongs to the Section Marine and Freshwater Biology)

Pollination Biology: 2nd Edition

edited by

Yu Gao

and

Bartosz Płachno

submission deadline 1 Oct 2026 | Viewed by 150 | Submission Open

Keywords: conservation biology; insect diversity; pollinator-plant interactions; ecosystem service; pollinating insect; flower; bee

(This special issue belongs to the Section Ecology)

Semaphorins as Drivers of Inflammatory Disease: Setting Immune Cells in Motion

edited by

Tiago Granja

submission deadline 3 Oct 2026 | Viewed by 65 | Submission Open

Keywords: semaphorins; inflammation; neuronal guidance proteins; soluble guidance cues; cell motility; cytoskeletal dynamics; extracellular matrix

(This special issue belongs to the Section Immunology)

Multi-omics Approaches in Agricultural Crops to Unravel Responses to Environmental Stresses and Advance Sustainable Agriculture

edited by

Vito Butardo

submission deadline 30 Oct 2026 | 2 articles | Viewed by 6112 | Submission Open

Keywords: plant functional genomics; environmental stress; climate change; crop yield; crop quality; nutritional properties; omics approaches; genomics; transcriptomics; proteomics; metabolomics; epigenomics; phenomics; stress-tolerant crops; breeding strategies; data integration; systems biology; sustainable agriculture; underutilized crops; orphan crops; beneficial microorganisms

(This special issue belongs to the Section Plant Science)

Pathophysiology of Hearing Loss

edited by Charles E. Bishop

submission deadline 30 Oct 2026 | 2 articles | Viewed by 2709 | Submission Open

Keywords: hearing loss; cochlea; noise; deafness genes; cell death; hair cells; inner ear; biotoxicity; metabolic risk; gene mutation; physiology and pathophysiology; animal models; biomarkers and molecular mechanisms

(This special issue belongs to the Section Physiology)

Molecular, Biophysical, and Neurophysiological Mechanisms Underlying Magnetoreception

edited by

Weidong Pan

and

Guijun Wan

submission deadline 30 Oct 2026 | Viewed by 157 | Submission Open

Keywords: earth magnetic field; magnetosensing; magnetite; radical pair; orientation; navigation; magnetic receptor; electroreceptor; neurophysiology

Animal Virus–Host Interactions and Cross-Species Dynamics

edited by

Anan Jongkaewwattana

and

Thanathom Chailangkarn

submission deadline 30 Oct 2026 | Viewed by 121 | Submission Open

Keywords: animal viruses; zoonosis; pathogenesis; host immunity; vaccines; antivirals; host– pathogen interaction; One Health; veterinary virology

(This special issue belongs to the Section Infection Biology)

Fatty Acid Metabolism and Inflammation

edited by

Mi-hee Park

submission deadline 30 Oct 2026 | Viewed by 93 | Submission Open

Keywords: fatty acid metabolism; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; Immune modulation; Inflammation; biomarkers

(This special issue belongs to the Section Physiology)

Advances in Zebrafish as an Experimental Model: From Husbandry to Cutting-Edge Applications

edited by Rosario Moyano-Salvago,

Rafael Mora Medina

and

Nahúm Ayala-Soldado

submission deadline 30 Oct 2026 | Viewed by 44 | Submission Open

Keywords: zebrafish; experimental model; developmental biology; genetics; gene editing; transgenesis; toxicology; regeneration; animal welfare; biomedical research

(This special issue belongs to the Section Zoology)

Immunosenescence and Its Modification by Interventions

edited by

Andreas Meryk

and Luca Pangrazzi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 6608 | Submission Open

Keywords: immunosenescence; aging immune system; inflammaging; vaccine efficacy in elderly; nutritional immunomodulation; exercise and immunity; senolytic therapies; T-cell exhaustion; thymic rejuvenation; age-related diseases

(This special issue belongs to the Section Immunology)

Mitochondria and Cardiovascular Diseases

edited by Qingxun Hu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3520 | Submission Open

Keywords: cardiovascular diseases; mitochondria; pathophysiology; cardiology; cell metabolism; animal models; epigenetics; redox biology

(This special issue belongs to the Section Physiology)

Advances in Plant Multi-Omics

edited by

Xiuzhang Li

, Zhonglong Guo and Xuekai Wei

submission deadline 31 Oct 2026 | 1 articles | Viewed by 717 | Submission Open

Keywords: multi-omics integration; plant systems biology; high-throughput sequencing; bioinformatics integration; stress response

(This special issue belongs to the Section Plant Science)

Transcriptional Regulation in Eukaryotes

edited by Anil Kumar Panigrahi

submission deadline 31 Oct 2026 | Viewed by 548 | Submission Open

Keywords: transcription factors (TFs); transcriptional coregulators; RNA polymerase II; chromatin modifications and remodeling; enhancers; silencers; non-coding RNAs; 3D chromatin architecture; multi-omics integration; single-cell technologies

(This special issue belongs to the Section Genetics and Genomics)

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