Energy Metabolism, Genetics and Development in Drosophila

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Bioinformatics".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1065

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Guest Editor
School of Systems Biomedical Science, Soongsil University, Seoul 06978, Republic of Korea
Interests: non-coding RNAs; R-loop; epigenetic regulation; Drosophila development
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Special Issue Information

Dear Colleagues,

Drosophila has been a key model organism in biological research for over a century, contributing to fundamental studies in genetics, developmental biology, energy metabolism, and more. Energy metabolism, a critical process related to development, is closely regulated in Drosophila and shares remarkable similarities with higher organisms, including humans. In this Special Issue, entitled “Energy Metabolism, Genetics and Development in Drosophila,” we will present innovative research that explores the fascinating relationships among energy metabolism, genetic regulation, and developmental processes in Drosophila. We welcome original research articles and reviews that address the interplay among energy metabolism, genetics, and development in Drosophila. The scope of this Special Issue includes, but is not limited to, the following topics:

  • Molecular mechanisms of metabolic regulation in Drosophila development;
  • Genetic and epigenetic control of energy metabolism;
  • Signaling pathways in growth and development;
  • Non-coding RNAs in metabolism and development;
  • Drosophila models for studying metabolic diseases.

We look forward to your contributions to this exciting Special Issue, which aims to advance our understanding of energy metabolism, genetics, and development in Drosophila and its broader implications for biology.

Dr. Do-Hwan Lim
Guest Editor

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Keywords

  • Drosophila
  • energy metabolism
  • development
  • epigenetics
  • non-coding RNAs
  • metabolic disease
  • growth
  • signaling pathway

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Published Papers (1 paper)

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Research

16 pages, 2751 KB  
Article
Drosophila miR-33-5p Suppresses Cell Growth by Inhibiting ERK Signaling
by Taeheon Lee, Nayeon Kim, Ye Jin Park, Seungeun Cha, Young Sik Lee and Do-Hwan Lim
Biology 2025, 14(12), 1693; https://doi.org/10.3390/biology14121693 - 28 Nov 2025
Viewed by 741
Abstract
Cell growth control is a critical process underlying diverse biological events, including survival, development, tissue repair, and disease. Growth regulation is orchestrated by a combination of external and internal cues, involving a multitude of signaling pathways. Nevertheless, our comprehension of the regulation of [...] Read more.
Cell growth control is a critical process underlying diverse biological events, including survival, development, tissue repair, and disease. Growth regulation is orchestrated by a combination of external and internal cues, involving a multitude of signaling pathways. Nevertheless, our comprehension of the regulation of growth-associated signaling pathways is still incomplete. In this study, we discovered that microRNA miR-33 overexpression in Drosophila S2 cells resulted in a reduction in cell proliferation. This growth inhibition was attributed to the inactivation of ERK signaling, which is mediated through Ras64B, a direct target of miR-33-5p. In accordance with these observations in S2 cells, miR-33 inactivation in Drosophila wings led to an increase in cell number, while its overexpression resulted in a decrease. Notably, miR-33-induced wing reduction was associated with diminished ERK signaling, and this wing defect was rescued by co-expression of Ras64B or a constitutively active ERK variant. Consequently, these findings establish miR-33–Ras64B–ERK as a regulatory axis, providing new mechanistic insights into growth control in Drosophila. Full article
(This article belongs to the Special Issue Energy Metabolism, Genetics and Development in Drosophila)
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