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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Natural Products as Candidates for the Discovery of Antimicrobial Drugs

edited by

Maya Zaharieva

and

Hristo Najdenski

submission deadline 15 Nov 2025 | 5 articles | Viewed by 27763 | Submission Open

Keywords: natural products; antimicrobial mechanisms and strategies; combination effects; clinical applicability; in silico; in vitro and in vivo models; infection control

(This special issue belongs to the Section Plant-Derived Antibiotics)

Pathogenic Microorganisms and Antibiotic Therapy in Infectious Disease

edited by

Angela Quirino

Grazia Pavia

and

Nadia Marascio

submission deadline 15 Nov 2025 | 2 articles | Viewed by 6081 | Submission Open

Keywords: antimicrobial resistance; pathogenic mechanisms; multidrug-resistant microorganisms; antimicrobial drugs; innovative therapeutic strategies

The Battle Against Urinary Tract Infections: The Role of Antibiotics

edited by

Pawel Miotla

and

Sara Wawrysiuk

submission deadline 15 Nov 2025 | 2 articles | Viewed by 2383 | Submission Open

Keywords: urinary tract infection (UTI); antibiotics; antimicrobial resistance (AMR); multidrug-resistant uropathogens; antibiotic stewardship; UTI treatment; novel antibiotics; phage therapy; UTI pathogenesis; probiotics in UTI management

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Resistance in Aquaculture: Balancing Health and Sustainability

edited by

Zhigang Zhou

submission deadline 15 Nov 2025 | 1 articles | Viewed by 708 | Submission Open

Keywords: antimicrobial resistance; aquaculture; one health approach; antibiotic stewardship; probiotics; zoonotic pathogens; resistance genes; sustainable practices; environmental impact

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Biomaterials for Dentistry

edited by

Edith Lara-Carrillo

submission deadline 18 Nov 2025 | Viewed by 282 | Submission Open

Keywords: antimicrobials; dentistry; microorganisms; biomaterials; caries risk; oral environment; epidemiology

Genomic Analysis of Antimicrobial Drug-Resistant Bacteria

edited by

Maria Rosario Rodicio

and

Carlos Rodriguez-Lucas

submission deadline 30 Nov 2025 | 7 articles | Viewed by 18001 | Submission Open

Keywords: antimicrobial drug resistance; whole-genome sequencing; genomic epidemiology; one health; bacterial pathogens; mobile genetic elements; horizontal gene transfer; phylogenetics; evolution

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Bioactive Peptides and Their Antibiotic Activity

edited by

Hamilton Cabral

submission deadline 30 Nov 2025 | 10 articles | Viewed by 16742 | Submission Open

Keywords: database peptides; therapeutic agents; peptide design; antimicrobial peptides; antibiotic resistance; therapeutic drugs

(This special issue belongs to the Section Antimicrobial Peptides)

Environmental Fate of Antibiotics: Monitoring, Toxicity, Resistance, and Removal Methods

edited by

Takashi Azuma

submission deadline 30 Nov 2025 | 6 articles | Viewed by 14979 | Submission Open

Keywords: antimicrobials; high-throughput analysis; wastewater treatment plant (WWTP); hospital wastewater; livestock environment; water purification plant (WTP); aquatic environment; environmental health risk assessment; antimicrobial resistance (AMR); advanced water treatment

Antibiotic Resistance and Virulence Mechanisms in Gram-Negative Bacteria: An Alliance for Success

edited by

Francesco Imperi

submission deadline 30 Nov 2025 | 8 articles | Viewed by 14239 | Submission Open

Keywords: virulence; Gram-negative; antimicrobial resistance; One Health

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Managing Appropriate Antibiotic Prescribing and Use in Primary Care

edited by

Ruby Biezen

submission deadline 30 Nov 2025 | 5 articles | Viewed by 11203 | Submission Open

Keywords: primary care; general practice; antimicrobial stewardship; antimicrobial resistance; infectious disease; appropriate prescribing; guidelines concordance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Development of Antimicrobial Peptides from Amphibian, 2nd Edition

edited by

Maria Luisa Mangoni

Bruno Casciaro

and Maria Rosa Loffredo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8448 | Submission Open

Keywords: frog skin-derived antimicrobial peptides; natural and synthetic AMPs; the synergy of AMPs; insights into the mechanism(s) of action of AMPs; drug delivery system

(This special issue belongs to the Section Antimicrobial Peptides)

Comprehensively Addressing Antimicrobial Resistance, Improving Food Safety and Achieving the One Health Goals: Global Challenges

edited by

Vladimir Kurćubić

, Pavle Mašković,

Milan N. Mitić

and

Nikola Stanišić

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7205 | Submission Open

Keywords: antimicrobial resistance (AMR); food safety; foodborne pathogens; antibiotic residues; natural antimicrobials; one health

Antibiotic and Antiparasitic Resistance in Veterinary Clinical Settings

edited by

Daphne Lianou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6521 | Submission Open

Keywords: animal; cattle; cat; dog; goat; horse; pig; poultry; sheep; therapeutics; treatment; veterinary; wildlife

(This special issue belongs to the Section Antibiotics in Animal Health)

Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Patients

edited by Young Ran Lee

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6471 | Submission Open

Keywords: therapeutic drug monitoring (TDM); antibiotics; antimicrobials; pharmacokinetic; pharmacodynamic; critically ill

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

The Antimicrobial Resistance in the Food Chain

edited by

Irene Dini

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5511 | Submission Open

Keywords: food safety; foodborne pathogens; pathways of antimicrobial resistance; antibiotic resistance; phenotypic analyses; molecular analyses; regulatory guidelines; food chemistry

Pharmacokinetics and Pharmacodynamics of Antibacterial and Antivirulence Drugs, 2nd Edition

edited by

Takahisa Yano

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4842 | Submission Open

Keywords: pharmacokinetics; pharmacodynamics; clinical trials; antimicrobial resistance; antibacterials; antivirulence drugs; pathoblockers; antimicrobial use; drug utilization studies; PK/PD modeling; PBPK-modeling

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Bacteriophages and Phage-Derived Enzymes as Antibacterial Agents

edited by

Grzegorz Wegrzyn

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4519 | Submission Open

Keywords: phage therapy; lytic bacteriophages; phage-derived enzymes; antibiotic resistance

(This special issue belongs to the Section Bacteriophages)

Antimicrobial Susceptibility of Veterinary Origin Bacteria

edited by Luchao Lv and Jing Wang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4224 | Submission Open

Keywords: antimicrobial resistance; animal-derived resistant; antimicrobial-resistant bacteria; foodborne pathogens

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Prescribing, Population Use and Resistance, Impact in Global Health, 3rd Edition

edited by

Juan Manuel Vázquez-Lago

Ana Estany-Gestal

and

Angel Salgado-Barreira

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4061 | Submission Open

Keywords: epidemiology; social behavior; antibiotic resistance; social factors; attitudes; knowledge; practice; qualitative research; public health interventions; antibiotic prescription; community care

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Spread of Multidrug-Resistant Microorganisms, 2nd Edition

edited by

Mara Di Giulio

and

Silvia Di Lodovico

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3787 | Submission Open

Keywords: multidrug-resistant organisms; MDR; antibiotic resistance gene; nosocomial infections; new marker of resistance

Innovations in Plant-Based Antibiotic and Antiviral Agents

edited by

Margherita-Gabriella De Biasi

and

Irene Dini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3769 | Submission Open

Keywords: secondary metabolites; phytochemicals; botanicals; analytical methods; toxicity

(This special issue belongs to the Section Plant-Derived Antibiotics)

A Themed Issue in Honor of Dr. Lynne V. McFarland—Clostridioides difficile Infection and Impact of Antibiotics on the Intestinal Microbiome

edited by Ellie J. C. Goldstein and Shan Goh

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2595 | Submission Open

Keywords: Clostridioides difficile infections; intestinal microbiome; infection control practices; antibiotic complications; probiotics; live biotherapeutic products; treatment; prevention

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotic Stewardship and Infection Control Strategies in Critical Care

edited by

Susana M. Fernandes

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2136 | Submission Open

Keywords: infection prevention; critical care; sepsis; stewardship practices

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Discovery of Novel Antimicrobial Agents to Combat Infections

edited by

Yuanpu Peter Di

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1487 | Submission Open

Keywords: antimicrobials; resistance; bacteriophage; virulence; structure; PD/PK; bacteria; virus; fungus

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Agents for Drug-Resistant Infections: From Identification to Preclinical and Clinical Trials

edited by

Javier Eduardo García Castañeda

and

Zuly Jenny Rivera-Monroy

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1212 | Submission Open

Keywords: antimicrobials agents; drug resistant; anti-cancerogenic agents; drug development; preclinical trials; clinical trials; pharmaceutical optimization

(This special issue belongs to the Section Novel Antimicrobial Agents)

Plant-Based Strategies for the Removal and Degradation of Antibiotics from the Environment

edited by

Giancarlo Angeles Flores

and

Paola Angelini

submission deadline 30 Nov 2025 | 1 articles | Viewed by 889 | Submission Open

Keywords: antibiotics; ARGs; phytoremediation; rhizosphere; plant– microbe interactions; biodegradation; detoxification; environmental pollution; resistance mitigation; sustainable remediation

Antibiotic Resistance and Antimicrobial Stewardship in Veterinary Medicine

edited by Tiana Florea,

Ilie Stelian

and

Degi Janos

submission deadline 30 Nov 2025 | 2 articles | Viewed by 881 | Submission Open

Keywords: antimicrobial stewardship; antibiotics; animals; sustainability; drugs; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Novel Approaches to Prevent and Combat Antimicrobial Resistance

edited by

Xiaotao Jiang

submission deadline 30 Nov 2025 | Viewed by 411 | Submission Open

Keywords: antimicrobial peptides; novel antibiotics screening; phage therapy; fecal microbiota transplantation (FMT); dietary and functional food interventions; AMR prevention strategies

Resistance and Evolving Biology in Mycobacteria: Multidisciplinarity as a Contemporary Approach

edited by

Irena Arandjelovic

and Dragana Vukovic

submission deadline 30 Nov 2025 | Viewed by 367 | Submission Open

Keywords: tuberculosis; drug resistance; evolutionary biology; pathogen-host interactions

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Drug Discovery in the Fight Against Bacterial Infections

edited by

Sara M. Soto

and

Raquel G. Soengas

submission deadline 30 Nov 2025 | Viewed by 342 | Submission Open

Keywords: drug discovery against gram-positive bacteria; drug discovery against gram-negative bacteria; drug discovery against fungi; drug discovery against biofilms

Neonatal Infection: Antibiotics for Prevention and Treatment

edited by Cinzia Auriti and Maria Paola Ronchetti

submission deadline 30 Nov 2025 | Viewed by 261 | Submission Open

Keywords: neonatal infections; neonatal sepsis; sepsis definition; antibiotics in newborns; antibiotic stewardship; sepsis biomarkers; sepsis diagnosis in newborns; epidemiology of neonatal infections; fungal invasive infections

Animal-Origin Bacteria: Diversity, Pathogenicity and Antimicrobial Resistance

edited by

Juliana Menezes

Joana Moreira da Silva

and

Adriana Belas

submission deadline 30 Nov 2025 | Viewed by 233 | Submission Open

Keywords: AMR; virulence; bacteria; zoonosis; companion animals; alternative therapy; food-producing animals; exotic animals; wildlife; One Health

Mastitis: Causative Agents, Drug Resistance, and Treatment Approaches—2nd Edition

edited by

Amira A. Moawad

Hosny El-Adawy

and Heinrich Neubauer

submission deadline 30 Nov 2025 | Viewed by 203 | Submission Open

Keywords: mastitis; etiology; multi-drug resistance; alternative bovine mastitis treatment; WGS

(This special issue belongs to the Section Antibiotics in Animal Health)

The Use of Systemic and Topical Antibiotics in Dentistry: Challenges and Future Perspectives

edited by

Sigrun Eick

and

Valentino Natoli

submission deadline 30 Nov 2025 | Viewed by 187 | Submission Open

Keywords: antibiotics; apical abscess; apical periodontitis; endodontic infection; periapical disease; mouth diseases; topical antibiotics; antimicrobial approaches

Risks and Current Knowledge of Antimicrobial Resistance in Companion Animals

edited by

Djamel Drider

and

Raffaele Scarpellini

submission deadline 30 Nov 2025 | Viewed by 168 | Submission Open

Keywords: antimicrobial resistance; companion animals; dogs; cats; clinically important antibiotics; One Health; reverse zoonosis; zoonosis; AMR epidemiology

(This special issue belongs to the Section Antibiotics in Animal Health)

Biosynthesis, Antimicrobial Activity, and Therapeutics Development of Novel Peptides

edited by

Jiajun Wang

submission deadline 30 Nov 2025 | Viewed by 165 | Submission Open

Keywords: peptide biosynthesis; novel antimicrobial peptides; antibiotic resistance; improvement of biological stability; optimization of drug delivery systems; immune regulation; AI-driven peptide design; innovation in the field of biomedicine

(This special issue belongs to the Section Antimicrobial Peptides)

Antimicrobial and Anti-Inflammatory Activity of Bioactive Compounds Extracted from Plants, 2nd Edition

edited by

Juliana Garcia

and

Irene Gouvinhas

submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open

Keywords: plants; phytochemicals; bioactive compounds; biological properties; natural products

(This special issue belongs to the Section Plant-Derived Antibiotics)

Small Intestinal Bacterial Overgrowth and Antimicrobials

edited by

Mislav Radić

and

Andrej Belančić

submission deadline 30 Nov 2025 | Viewed by 147 | Submission Open

Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Interventions to Prevent and Reduce Healthcare-Associated Infection

edited by Nasia Safdar

submission deadline 30 Nov 2025 | Viewed by 102 | Submission Open

Keywords: infection; resistance; methicillin-resistant Staphylococcus aureus; vancomycin resistant enterococcus; Clostridioides difficile infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Sustainable Innovation in Antibiotic Adjuvants: Developing Strategies to Overcome Antibiotic Resistance and Biofilm Infections

edited by

Anabela Borges

and

Ana C. Afonso

submission deadline 1 Dec 2025 | Viewed by 188 | Submission Open

Keywords: adjuvants; antibiotic resistance; biofilms; drug development; green chemistry; natural products; synergistic interactions

(This special issue belongs to the Section Biosynthesis and Combinatorial Approaches in Antimicrobial Discovery)

Surveillance and Molecular Diagnosis of Antimicrobial-Resistant Pathogens: From Laboratory to Clinical Practice

edited by Neena Kanwar

submission deadline 5 Dec 2025 | Viewed by 127 | Submission Open

Keywords: clinical microbiology; molecular diagnostics; infectious disease epidemiology; antimicrobial susceptibility; microbial culture

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Urinary Tract Infections and Antibiotic Intervention, 2nd Edition

edited by

Majid Mirzazadeh

submission deadline 10 Dec 2025 | Viewed by 392 | Submission Open

Keywords: UTI; antibiotic; microbiome; PCR; next-generation sequencing; urine culture; enhanced quantitative urine cultures; urinary sepsis

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Spread of Antibiotic Resistance in Natural Environments

edited by

Daniel Gyamfi Amoako

submission deadline 15 Dec 2025 | 6 articles | Viewed by 20973 | Submission Open

Keywords: antibiotic resistance dissemination; antibiotic pollution; environmental adaptation; mobile genetic elements; ecological impact; environmental microbiome; resistance gene transfer; resistance hotspot; genomic landscape; One Health approach; emerging contaminants; bioinformatics in environmental genomics

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Resistance and Environmental Health, 2nd Edition

edited by

Akebe Luther King Abia

submission deadline 15 Dec 2025 | 2 articles | Viewed by 3619 | Submission Open

Keywords: public health; environmental health; antibiotic resistance; environmental resistome; antibiotic-resistant bacteria; whole-genome sequencing; metagenomics; climate change and AMR; AMR models and One Health

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Surveillance and Rational Use in Special Populations: Enhancing Stewardship for Vulnerable Groups

edited by

Phumzile P Skosana

and

Filippo Mariano

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2035 | Submission Open

Keywords: antibiotic stewardship; surveillance systems; special populations; rational use of antibiotics; infectious disease management

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Challenges of Antibiotic Resistance: Biofilms and Anti-Biofilm Agents

edited by

María Melissa Gutiérrez-Pacheco

and

Luis Alberto Ortega-Ramirez

submission deadline 20 Dec 2025 | Viewed by 457 | Submission Open

Keywords: antibiotic resistance; biofilms; quorum sensing; virulence factors; resistance mechanisms; antibiofilm agents; natural compounds; synthetic drugs

(This special issue belongs to the Section Antibiofilm Strategies)

Environmental Risk and Antibiotic Resistance in Hospital-Acquired Infections

edited by

Catherine Neuwirth

submission deadline 20 Dec 2025 | Viewed by 151 | Submission Open

Keywords: nosocomial outbreak; environmental reservoir; investigation; corrective actions; short- and long-term outcomes

Phage Applications from Diagnostics to Treatment of Bacterial Infections in a One Health World

edited by

Mariagrazia Di Luca

and

Goran Vukotic

submission deadline 31 Dec 2025 | 8 articles | Viewed by 43166 | Submission Open

Keywords: phage therapy; antibiotic resistance; bacteriophages; regulatory framework; veterinary medicine; agriculture treatment; aquaculture

(This special issue belongs to the Section Bacteriophages)

Antibiotic Use and Antimicrobial Stewardship for Children in the Emergency Department

edited by

Michael Barrett

and

Spyridon Karageorgos

submission deadline 31 Dec 2025 | 7 articles | Viewed by 41390 | Submission Open

Keywords: pediatric ED; ambulatory; antimicrobial stewardship; antibiotic use; antimicrobial resistance; point-of-care testing

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Bacterial Detection, Identification, and Antimicrobial Susceptibility Testing

edited by

Gabriele Bianco

submission deadline 31 Dec 2025 | 8 articles | Viewed by 28677 | Submission Open

Keywords: identification methods; rapid diagnostics; MALDI-TOF MS; molecular testing; rapid antimicrobial susceptibility testing; antimicrobial susceptibility; synergy testing; β -lactam/β -lactamase inhibitor; fosfomycin; colistin

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