2026 September - 15 articles
Background/Objectives: The therapeutic durability of β-lactams is increasingly threatened by penicillin-binding proteins (PBPs) that retain cell-wall transpeptidase activity under antibiotic pressure. This study computationally evaluated 221 Dan...
Proteolytic processing of viral polyproteins by virally encoded proteases is essential for the replication of many RNA viruses, including retroviruses and coronaviruses, which are two of the best characterized model systems discussed in this review....
Background: Candida albicans can adapt to inhibition of the classical mitochondrial respiratory chain by activating an alternative oxidase (AOX)-dependent pathway, whereas Candida glabrata lacks detectable AOX-mediated respiration under the condition...
Background: The leading cause of cancer-related deaths globally is lung cancer, and the P2X7 receptor (P2X7R) is a promising therapeutic target due to its role in the disease progression. Methods: A deep learning-based molecular generation framework...
The global emergence of multidrug-resistant fungal pathogens, including Candida auris, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Pneumocystis jirovecii, poses a growing threat to public health, particularly among immunocom...
Background/Objectives: This study investigated the effects of a single dose of psilocybin-containing Psilocybe cubensis extract on gut microbiota composition, microbial metabolism, and intestinal immune-related responses. Methods: A single dose of P....
The 33rd Annual Conference of the Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A), held in Nantes from 11 to 13 June 2025, marked a significant expansion of the organization’s scope and collaborative efforts. Building on...
Background. Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used treatments for mild to moderate pain and fever in pediatric patients. Notwithstanding, greater caution and awareness of their distinct safety profiles is warra...
Hypertension is a major global health concern affecting over one billion people worldwide and is a leading risk factor for cardiovascular diseases, stroke, and kidney failure. Plant-derived bioactive compounds provide promising natural strategies for...
Backgrounds: Astragalus membranaceus (AM), a traditional Chinese medicinal herb, has garnered interest for its potential in anticancer therapy. Preclinical evidence suggests that AM inhibits tumor growth and could mitigate the adverse effects as...
Background: Geraniol is an acyclic monoterpene widely distributed in the essential oils of aromatic species such as Cymbopogon citratus, Pelargonium graveolens, and Rosa damascena, It is known for its antioxidant, anti-inflammatory, neuroprotective,...
Carbapenem-resistant Acinetobacter baumannii (CRAB) is classified by the World Health Organization among the critical-priority pathogens, reflecting high mortality, near-ubiquitous nosocomial spread, and a depleted therapeutic pipeline. No antibiotic...
Drug recall is a critical regulatory mechanism implemented to protect public health by removing defective, unsafe, or non-compliant pharmaceutical products from the market. Despite stringent regulatory approval processes, issues related to manufactur...
One of the most pressing challenges facing healthcare today is the rise of biofilm infections and antibiotic-resistant bacteria, which demand entirely new therapeutic strategies beyond conventional antibiotic reliance. A biofilm is a structured commu...
Background: Microbiome-oriented therapies, including fecal microbiota transplantation (FMT), phage therapy, and live biotherapeutic products (LBPs), represent a promising direction in modern biomedicine for addressing antimicrobial resistance (AMR),...
