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Biologics, or Biopharmaceuticals, can be defined as drugs derived from biological sources. Engineered proteins and glycoproteins are prominent in this field since the introduction of human insulin encoded in recombinant DNA in 1982. Biologics now include hundreds of monoclonal antibodies (some ve...

Natural resources have been used for their healing properties and as pharmaceutical raw materials in several traditional medicine systems for years. They have shown different biological activities with the active metabolites they contain. Today, many compounds of natural origin and their derivati...

The section of In Silico Approaches in Drug Discovery welcomes manuscripts involving aspects within the definition of computational medicinal chemistry and computational structural biology related to the invention, discovery, design, screening, and identification of biologically ...

The aim of this section is to provide a wide panel of readers with a clear, accurate, and objective information on marketed therapeutic agents, not only for human use but also for veterinary use. In those manuscripts, synthetic routes, but also pharmacological targets, and economical point of vie...

The aim of this section is to disclose experimental procedures of preparation of novel drug candidates, including use of special methodologies and any effort made in order to improve yields or environmental impact. Biomolecules (oligonucleotides, peptides, oligosaccharides), active ingredients of...

The aim of this section is to cover the different steps that a lead must undergo in order to become a promising drug candidate. Among those steps, mention can be made of in-depth in vitro evaluation as well as pharmacological studies and determination of efficacy and toxicity in animal models (AD...