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International Journal of Translational Medicine, Volume 6, Issue 3

2026 September - 16 articles

Cover Story: Breast implants are widely used in aesthetic and reconstructive surgery and are not associated with an increased risk of breast carcinoma. However, increasing attention has focused on a spectrum of implant-associated conditions, including rare malignancies, breast implant illness, and autoimmune or inflammatory manifestations. This review explores the emerging concept of the host–implant–microbiome interface, where implanted biomaterials, microbial communities, and immune responses interact over time. By integrating evidence from oncology, immunology, microbiology, and biomaterials research, the article highlights how chronic low-grade inflammation and persistent immune stimulation may contribute to diverse local and systemic manifestations and provides a framework for future investigation. View this paper
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Articles (16)

  • Review
  • Open Access
501 Views
23 Pages

Muscle Dysfunction as the Missing Link in Ventral Hernia Pathogenesis: Toward a Functional Herniology Framework

  • Maria A. Sukhanova,
  • Zakhar A. Akulov,
  • Miroslava O. Pilipenko,
  • Zelimkhan G. M. Berikkhanov and ,
  • Alexey L. Shestakov,
  • Evgeniy A. Tarabrin,
  • Andrey M. Nikolaev,
  • Vladislav S. Rakintsev,
  • Sara Nourmahal and
  • Sergey Yu. Muraviev
  • + 5 authors+ 0 author

This study aimed to perform a conceptual analytical synthesis of the available evidence on the functional state of the musculofascial system of the anterior abdominal wall in ventral hernia, to appraise the potential contribution of muscular dysfunct...

  • Review
  • Open Access
620 Views
21 Pages

Stem cell transplantation represents a promising approach to regenerative medical therapies for many disorders, including neurodegenerative, rheumatologic, digestive, orthopedic, hematologic and cardiovascular diseases. In the case of stem cell thera...

  • Review
  • Open Access
852 Views
28 Pages

Human skin remains difficult to model in vitro because it brings together stratified epidermal, dermal, hypodermal, vascular, immune, appendageal, neural, and microbial elements within a single tissue. Traditional two-dimensional cultures and animal...

  • Review
  • Open Access
764 Views
27 Pages

Matrix metalloproteinases (MMPs) have long been recognized as key mediators of tumor invasion and metastasis due to their capacity to degrade extracellular matrix components. However, clinical failure of broad-spectrum MMP inhibitors has revealed a m...

(This article belongs to the Topic Molecular Drivers and Precision Therapeutics in Oncology)
  • Article
  • Open Access
453 Views
13 Pages

Longitudinal Ocular Surface Microstructural Findings After Switching to Preservative-Free Dorzolamide/Timolol in POAG: An Exploratory IVCM Pilot Case Series

  • Ana Sanseau,
  • Arturo Burchakchi,
  • Fernando Cataldi,
  • Héctor Fontana and ,
  • Alejo Peyret,
  • Giselle Rodríguez,
  • Ailín Fantacone,
  • María Silvia Passerini,
  • Javier Fernando Casiraghi and
  • Analía Luna
  • + 5 authors+ 0 author

Background and Objectives: To describe longitudinal ocular-surface microstructural findings on in vivo confocal microscopy (IVCM) after switching from benzalkonium chloride-preserved dorzolamide 2%/timolol 0.5% (BAK-DT) to preservative-free dorzolami...

  • Article
  • Open Access
565 Views
9 Pages

Efficacy of Doxycycline as Monotherapy or in Combination with Levofloxacin in Treating Late-Stage Systemic Anthrax in Non-Human Primates

  • Amir Ben-Shmuel,
  • Assa Sittner,
  • Itai Glinert,
  • Elad Bar-David and ,
  • Josef Schlomovitz,
  • Haim Levy and
  • Shay Weiss
  • + 2 authors+ 0 author

Background: Bacillus anthracis spores pose a major biosecurity threat, in light of their use in several documented bioterror attacks and the fact that it was weaponized. The absence of specific and accurate treatment instructions in the 2001 anthrax...

  • Article
  • Open Access
1,541 Views
15 Pages

Background and Objectives: Tumour necrosis factor alpha (TNF-α) inhibitors are widely used for moderate-to-severe psoriasis and are known to induce autoantibody formation in a proportion of treated patients. This study evaluated changes in ANA/...

  • Review
  • Open Access
693 Views
34 Pages

Retinal Microvascular Biomarkers of Exercise and Physical Fitness: A Systematic Review with Narrative Synthesis

  • Iva Macan,
  • Marija Jelić Vuković,
  • Suzana Matić,
  • Ena Kolak and ,
  • Stipe Vidović,
  • Marija Olujić,
  • Petar Šušnjara,
  • Dubravka Biuk,
  • Sanja Masnec and
  • Zvonimir Tomac
  • + 5 authors+ 0 author

Background: Retinal microvascular assessment has emerged as a promising non-invasive approach for evaluating vascular health. Recent advances in retinal imaging technologies have enabled detailed characterization of retinal vascular structure and fun...

  • Article
  • Open Access
493 Views
11 Pages

The Relationship Between Coronary Artery Ectasia and PAI-1 4G/5G Gene Polymorphisms

  • Muhammet Ergül,
  • Yüksel Çiçek,
  • Ali Gökhan Özyıldız,
  • Faruk Saydam and
  • Elif Ergül

Background: Coronary artery ectasia (CAE) is characterized by either diffuse or segmental enlargement of the coronary artery, with a diameter that exceeds 1.5 times that of the adjacent normal vessel. The underlying causes of CAE remain inadequately...

  • Review
  • Open Access
904 Views
18 Pages

Background/Objectives: Breast implants are widely used in aesthetic and reconstructive surgery. Although they are not associated with an increased risk of breast carcinoma, growing attention has focused on implant-associated conditions, including bre...

  • Article
  • Open Access
431 Views
14 Pages

Background: Food-based delivery systems are essential for the practical application of probiotics. A key challenge in translating this technology is determining whether the bacteria remain viable and biologically active after being incorporated into...

  • Article
  • Open Access
1,031 Views
19 Pages

Whole-Exome Sequencing Utility and Drug Resistance in a Real-World Epilepsy Cohort from Southern Kazakhstan

  • Islamkhan Doszhanov,
  • Sandugash Rustemova,
  • Nigara Yerkhojayeva,
  • Nursultan Nurdinov and ,
  • Rauan Kaiyrzhanov,
  • Aziza Djurabekova,
  • Gulzira Baimakhanova,
  • Nazira Zharkinbekova,
  • Aigerim Togizbayeva and
  • Nurlybek Mombekov
  • + 5 authors+ 0 author

Background/Objectives: In resource-limited regions, limited access to genetic testing may delay etiological diagnosis in selected patients with epilepsy and complex neurological manifestations, particularly when the phenotype raises suspicion of an u...

  • Article
  • Open Access
945 Views
18 Pages

Dysregulation of the miR-34a/SIRT1 Regulatory Network Is Associated with Cardiometabolic Risk in Type 2 Diabetes

  • Fábio Morato de Oliveira,
  • Fermino Sanches Lizarte Neto,
  • Eduardo Vignoto Fernandes,
  • Mayara Bocchi and ,
  • David Michel de Oliveira and
  • Carla Silva Siqueira
  • + 1 author+ 0 author

Background: Although conventional cardiovascular risk scores are widely used, they do not fully capture the molecular mechanisms underlying vascular injury in type 2 diabetes mellitus (T2DM). This study investigated the association between the miR-34...

(This article belongs to the Topic Future Directions in Cardiology: How the Clinic Will Change in the Coming Years, the Laboratory Always Standing)
  • Study Protocol
  • Open Access
566 Views
14 Pages

Background: Designing studies to increase knowledge of the beneficial effects of volatile halogenated anaesthetics(VHAs) is critical to understand the mechanisms activated by myocardial conditioning during ischaemia-reperfusion(I/R) injury. Our resea...

  • Review
  • Open Access
1,797 Views
15 Pages

For decades, peritoneal metastases (PM) have been regarded as a terminal manifestation of advanced malignancies and managed primarily with palliative intent because of limited sensitivity to systemic therapies. Accumulating clinical, molecular, and i...

  • Review
  • Open Access
1,273 Views
16 Pages

Background/Objectives: To compare the efficacy and safety of a single dose versus three weekly doses of benzathine penicillin G (BPG) for the treatment of early syphilis. Methods: We searched Embase, PubMed, and Scopus for randomized controlled trial...

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Int. J. Transl. Med. - ISSN 2673-8937