Background/Objectives: Glucose-lowering treatment can change insulin resistance indices without demonstrating improved insulin sensitivity. We described these changes during sodium–glucose cotransporter-2 (SGLT2) inhibitor therapy in routine ca...
Late distant recurrence in estrogen receptor-positive (ER+) breast cancer raises the question of how disseminated tumor cells resume proliferation years after primary tumor resection. We propose two coupled processes: endocrine–immune condition...
In the original publication [...]
In the original publication [...]
Background/Objectives: Polycystic ovary syndrome (PCOS), renamed polyendocrine metabolic ovarian syndrome (PMOS) in 2026, is a heterogeneous endocrine–metabolic disorder. Asparagus racemosus (Shatavari) is widely used for women’s reproduc...
Background: Large language models (LLMs) can generate clinically relevant information, but safety-related performance in systemic lupus erythematosus (SLE) remains insufficiently characterised. We compared GPT-5.5 Instant (ChatGPT), Claude Sonnet 4.6...
Background: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy in which relapse and treatment resistance remain major clinical challenges. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has...
Healthspan, the period of life free from major chronic disease and disability, is a central geroscience outcome, yet its prediction remains difficult due to its multidimensional and heterogeneous nature. In this review, we synthesize advances in arti...
Background: Melatonin concentrations in follicular fluid exceed serum levels, suggesting local ovarian accumulation and a potential role in the follicular microenvironment. Previous studies reporting associations between intrafollicular melatonin and...
The International Journal of Translational Medicine (IJTM) [...]
Background/Objectives: Low-dose phthalate exposure acts as an adjuvant for immunoglobulin production and exacerbates atopic dermatitis (AD)-like lesions; however, research on orally administered di-(2-ethylhexyl) phthalate (DEHP)-mediated AD aggravat...
This study aimed to perform a conceptual analytical synthesis of the available evidence on the functional state of the musculofascial system of the anterior abdominal wall in ventral hernia, to appraise the potential contribution of muscular dysfunct...
Stem cell transplantation represents a promising approach to regenerative medical therapies for many disorders, including neurodegenerative, rheumatologic, digestive, orthopedic, hematologic and cardiovascular diseases. In the case of stem cell thera...
Human skin remains difficult to model in vitro because it brings together stratified epidermal, dermal, hypodermal, vascular, immune, appendageal, neural, and microbial elements within a single tissue. Traditional two-dimensional cultures and animal...
Matrix metalloproteinases (MMPs) have long been recognized as key mediators of tumor invasion and metastasis due to their capacity to degrade extracellular matrix components. However, clinical failure of broad-spectrum MMP inhibitors has revealed a m...
Background and Objectives: To describe longitudinal ocular-surface microstructural findings on in vivo confocal microscopy (IVCM) after switching from benzalkonium chloride-preserved dorzolamide 2%/timolol 0.5% (BAK-DT) to preservative-free dorzolami...
Background: Bacillus anthracis spores pose a major biosecurity threat, in light of their use in several documented bioterror attacks and the fact that it was weaponized. The absence of specific and accurate treatment instructions in the 2001 anthrax...
Background and Objectives: Tumour necrosis factor alpha (TNF-α) inhibitors are widely used for moderate-to-severe psoriasis and are known to induce autoantibody formation in a proportion of treated patients. This study evaluated changes in ANA/...
Background: Retinal microvascular assessment has emerged as a promising non-invasive approach for evaluating vascular health. Recent advances in retinal imaging technologies have enabled detailed characterization of retinal vascular structure and fun...
Background: Coronary artery ectasia (CAE) is characterized by either diffuse or segmental enlargement of the coronary artery, with a diameter that exceeds 1.5 times that of the adjacent normal vessel. The underlying causes of CAE remain inadequately...
Background/Objectives: Breast implants are widely used in aesthetic and reconstructive surgery. Although they are not associated with an increased risk of breast carcinoma, growing attention has focused on implant-associated conditions, including bre...
Background: Food-based delivery systems are essential for the practical application of probiotics. A key challenge in translating this technology is determining whether the bacteria remain viable and biologically active after being incorporated into...
Background/Objectives: In resource-limited regions, limited access to genetic testing may delay etiological diagnosis in selected patients with epilepsy and complex neurological manifestations, particularly when the phenotype raises suspicion of an u...
Background: Although conventional cardiovascular risk scores are widely used, they do not fully capture the molecular mechanisms underlying vascular injury in type 2 diabetes mellitus (T2DM). This study investigated the association between the miR-34...
Background: Designing studies to increase knowledge of the beneficial effects of volatile halogenated anaesthetics(VHAs) is critical to understand the mechanisms activated by myocardial conditioning during ischaemia-reperfusion(I/R) injury. Our resea...
For decades, peritoneal metastases (PM) have been regarded as a terminal manifestation of advanced malignancies and managed primarily with palliative intent because of limited sensitivity to systemic therapies. Accumulating clinical, molecular, and i...
Background/Objectives: To compare the efficacy and safety of a single dose versus three weekly doses of benzathine penicillin G (BPG) for the treatment of early syphilis. Methods: We searched Embase, PubMed, and Scopus for randomized controlled trial...
Background: Neonatal aortic coarctation (CoA) remains difficult to diagnose before hemodynamic deterioration occurs after ductal closure. Pulse wave velocity (PWV) may reflect functional vascular alterations associated with CoA. Methods: A simplified...
Introduction: Steroid-resistant nephrotic syndrome (SRNS) represents a severe and challenging form of pediatric nephrotic syndrome and is associated with a high risk of progression to end-stage kidney disease. Calcineurin inhibitors (CNIs) are the st...
Background: Acute limb ischemia (ALI) is a vascular emergency characterized by abrupt limb hypoperfusion, ischemia–reperfusion injury, and a high risk of thromboinflammatory and organ complications. Complement activation has been implicated in...
Background/Objectives: Machine learning approaches are widely used in modern medical diagnostics, including cancer detection. The results can be significantly improved by aggregating individual measurements, and appropriate aggregation methods should...
Background/Objectives: Multiple myeloma (MM) is a genetically complex hematological neoplasm driven by accumulating genomic events. Despite therapeutic advances, MM remains an incurable disease with a complex molecular picture. Characterizing copy nu...
Background/Objectives: Posterior cortical atrophy, also referred to as Benson’s syndrome, is a presentation of Alzheimer’s disease that occurs in 5–15% of Alzheimer’s patients. Visual processing is the predominantly affected m...
Background/Objectives: Osteoarthritis (OA) is an age-related degenerative joint disease whose pathogenic mechanisms remain poorly understood. Experimental evidence implicates dysregulated mechanotransduction mediated by Piezo1 and TRPV4 channels, but...
Background/Objectives: Glypican-1 (GPC1) is a heparan sulfate proteoglycan that plays a critical role in regulating various signaling pathways and tumor development. Overexpression of GPC1 promotes tumor cell proliferation and invasiveness, and is as...
Background/Objectives: Immune checkpoint inhibitors (ICIs) improve outcomes in metastatic non-squamous non-small cell lung cancer (NSCLC), yet predictive biomarkers remain limited. This study investigated whether CD34-stained microvessel density (MVD...
Mild traumatic brain injury (mTBI) contributes substantially to years lived with disability (YLD), decreases health-related quality of life, and imposes significant costs on healthcare systems and society. Millions of people experience mTBI each year...
Background: The long-term cardiovascular safety of high-dose intravenous mesenchymal stem cell (MSC) therapy remains insufficiently characterized in real-world clinical settings. Methods: We conducted a single-center retrospective observational study...
Background/Objectives: The increasing sensitivity of molecular diagnostic techniques has led to the frequent detection of low-level JAK2 V617F mutations in individuals without overt myeloproliferative neoplasms (MPNs), creating uncertainty regarding...
Background: Conventional urothelial carcinoma (UC) requires accurate risk stratification, particularly differentiation between non-muscle-invasive (NMIBC) and muscle-invasive bladder cancer (MIBC) and between low- and high-grade tumors. This study ev...
Background: Despite well-established treatment and follow-up protocols for the management of colorectal cancer patients, recurrences are frequent. Post curative therapy, ctDNA-based molecular residual disease assessment has the ability to stratify pa...
Background: Mitotane is the cornerstone adjuvant and palliative treatment for adrenocortical carcinoma (ACC), requiring strict therapeutic drug monitoring (TDM) due to its narrow therapeutic window and high inter- and intra-individual pharmacokinetic...
Background: Chronic shoulder pain is a frequent musculoskeletal complaint that significantly affects function, productivity, and quality of life. Mesenchymal stem cell (MSC)-based therapies have emerged as a potential regenerative option due to their...
Introduction: Early HIV replication in the gastrointestinal tract plays an important role in HIV pathogenesis. We have followed the onset of the acquired immune deficiency disease (AIDS) pandemic and human immunodeficiency virus (HIV) infection from...
Zebrafish (ZF) have gained increasing attention in developmental neuroscience due to their experimental tractability, favorable ethical profile, and translational value. However, the expanding use of the ZF model has also highlighted the need to cons...
Background: Scattering of the sclera limits optical coherence tomography (OCT) imaging of deeper targets including lesions, malignancies, and other surgical targets. While existing applications of fluorescein dye are currently focused on fluorescence...
Oncofetal reprogramming has recently emerged as a critical concept in translational cancer research, particularly for its role in driving therapeutic resistance across a variety of malignancies. This biological process refers to a pattern of gene exp...
Background: We describe the post-mortem analysis of a CARD11 variant allele, p.Ser995Leu, identified in fraternal twins who died in early infancy with no identifiable cause of death. CARD11 variants through varied inheritance models can alter immune...
Idiopathic inflammatory myopathies (IIM) comprise a heterogeneous group of autoimmune disorders with variable systemic involvement. Among them, dermatomyositis (DM) is the subtype with the most extensive biomarker characterization due to its defined...
Background/Objectives: GATA-binding protein 3 (GATA-3) is a crucial transcription factor that drives type 2 immune responses, and it is actively involved in allergic conditions such as asthma, allergic rhinitis (AR), and atopic dermatitis (AD). Howev...
