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International Journal of Translational Medicine, Volume 4, Issue 2

2024 June - 14 articles

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Articles (14)

  • Communication
  • Open Access
5 Citations
4,048 Views
6 Pages

The Role of Serum IgG Precipitins against Six Typical Organic Antigens Involved in Hypersensitivity Pneumonitis: A 10-Year Retrospective Study of a Referral Interstitial Lung Disease Centre

  • Jari Intra,
  • Alice Biffi,
  • Francesca Basta,
  • Cristina Delfini and ,
  • Nicoletta Novati,
  • Elisa Zucchetti,
  • Fabrizio Luppi and
  • Marco Casati
  • + 3 authors+ 0 author

Hypersensitivity pneumonitis (HP) represents the third common interstitial lung disease caused by an exaggerated immune response following the inhalation of organic and/or chemical environmental antigens. The aim of this study was to determine the cu...

  • Review
  • Open Access
3 Citations
6,200 Views
12 Pages

High-density lipoprotein cholesterol (HDL) has long been regarded as a protective factor against cardiovascular disease (CVD). However, recent research challenges this notion, suggesting that HDL functionality rather than its quantity may be a more a...

(This article belongs to the Collection Feature Papers in International Journal of Translational Medicine)
  • Article
  • Open Access
1 Citations
2,133 Views
15 Pages

GAS2 Upregulation Is a Targetable Vulnerability in Chronic Myeloid Leukemia

  • Lizbeth A. Ramirez-Guzman,
  • Wenjing Huang,
  • John J. Cole and
  • Heather G. Jørgensen

Tyrosine kinase inhibitors (TKIs), such as imatinib (IM), increase the survival of chronic myeloid leukemia (CML) patients but do not eradicate the disease as leukemia stem cells (LSCs) with primitive and quiescent signatures persist after TKI monoth...

  • Article
  • Open Access
1 Citations
3,961 Views
12 Pages

Flapless Dental Implant Surgery in Bleeding Disorders

  • Federica Benetello,
  • Ezio Zanon,
  • Luca Sbricoli and
  • Christian Bacci

Hemostasis disorders require particular attention in dental treatment. Dental implants are a very widespread and valid method for total rehabilitation. Flapless dental implant surgery is a minimally invasive treatment that allows the implants to be p...

  • Article
  • Open Access
2 Citations
6,032 Views
8 Pages

Acute Management of Paroxysmal Atrial Fibrillation with Intravenous Flecainide plus Oral Beta-Blockers

  • Athanasios Kartalis,
  • Dimitrios Afendoulis,
  • Petros Voutas,
  • Maria Moutafi and ,
  • Nikolaos Papagiannis,
  • Stefanos Garoufalis,
  • Nikolaos Kartalis,
  • Nikolaos Smyrnioudis,
  • Antonios Ziakas and
  • Matthaios Didagelos
  • + 5 authors+ 0 author

Background: Intravenous (IV) flecainide is recommended for the pharmacological cardioversion of recent-onset atrial fibrillation (AF). The aim of this study was to study the efficacy and safety of IV flecainide, co-administered with oral b-blockers,...

(This article belongs to the Collection Feature Papers in International Journal of Translational Medicine)
  • Review
  • Open Access
6 Citations
8,905 Views
25 Pages

Many ailments can be diagnosed while they are asymptomatic, meaning that the patient has no signs or symptoms of a progressing disease. If caught in their initial stage of formation, these disorders can be effectively treated, leading to successful o...

  • Article
  • Open Access
2 Citations
8,547 Views
11 Pages

Assessment of Gamma Knife Stereotactic Radiosurgery as an Adjuvant Therapy in First-Line Management of Newly Diagnosed Glioblastoma: Insights from Ten Years at a Neuroscience Center

  • Jose E. Valerio,
  • Aizik Wolf,
  • Xiaodong Wu,
  • Noe Santiago Rea and ,
  • Maria Fernandez Gomez,
  • Matteo Borro and
  • Andres M. Alvarez-Pinzon
  • + 2 authors+ 0 author

Gamma knife radiosurgery (GKRS), a form of stereotactic radiosurgery (SRS), has gained importance in treating glioblastoma alongside conventional chemotherapy. This study aims to assess the efficacy of combining GKRS with surgery and chemotherapy to...

(This article belongs to the Special Issue Trends of Translational Medicine for Oncology)
  • Article
  • Open Access
3 Citations
3,335 Views
12 Pages

Euonymus alatus Extract Reduces Insulin Resistance in db/db Mice by Regulating the PI3K–AKT Pathway

  • Seoung-Uk. Lee,
  • Pallavi Gurung,
  • Til Bahadur Thapa Magar,
  • Junmo Lim and ,
  • Rajeev Shrestha,
  • Yoon-Hee Kim and
  • Yong-Wan Kim
  • + 2 authors+ 0 author

In accordance with the usage of Euonymus alatus (EA) as folk medicine in diabetes, the present study employed water and 70% ethanol twig extract to assess its antidiabetic effects in C57BL/KsJ-db/db mice. These effects were then compared with those o...

  • Article
  • Open Access
7 Citations
6,655 Views
8 Pages

From Mind to Plate to Pillow: Examining the Interplay of Mental Health, Eating Disorders, and Sleep Quality

  • Efstratios Christodoulou,
  • Verra Markopoulou and
  • Antonios E. Koutelidakis

In the context of the contemporary accelerated pace of life, emphasizing the importance of sleep quality is essential for enhancing overall well-being and health. Historically underestimated, recent studies highlight sleep’s vital importance fo...

(This article belongs to the Collection Feature Papers in International Journal of Translational Medicine)
  • Article
  • Open Access
7 Citations
4,036 Views
16 Pages

ROS-Responsive PLGA-NPs for Co-Delivery of DTX and DHA for Colon Cancer Treatment

  • Roberta Cassano,
  • Sonia Trombino,
  • Federica Curcio,
  • Roberta Sole and ,
  • Gabriella Calviello and
  • Simona Serini
  • + 1 author+ 0 author

The aim of this work was to evaluate the antineoplastic effect of newly synthesized nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) alone or PLGA esterified with 2,2′-[propane-2,2-diylbis (thio)] diacetic acid (TKL), loaded with doc...

  • Review
  • Open Access
11 Citations
4,773 Views
15 Pages

After an initial positive response to chemotherapy, cancer patients often acquire chemoresistance and tumor relapse, which makes cancer one of the most lethal diseases worldwide. Exosomes are essential mediators of cell-to-cell communication by deliv...

(This article belongs to the Collection Feature Papers in International Journal of Translational Medicine)
  • Brief Report
  • Open Access
3,103 Views
9 Pages

An Interdisciplinary Approach to Biobanking in Cardiac Surgery: Protocol of a Prospective, Single-Center Research Project Involving Longitudinal Biobanking

  • Theresa Holst,
  • Angela Langer,
  • Tatiana M. Sequeira Gross,
  • Noureldin Abdelmoteleb and ,
  • Valentina Miskovic,
  • Lisa Müller,
  • Sina Stock,
  • Bruno Märkl and
  • Evaldas Girdauskas
  • + 4 authors+ 0 author

Cross-sectional and longitudinal profiling of full sets of nucleic acids, peptides, or proteins as well as metabolites expressed in biospecimens acquired via a cardiovascular disease-oriented biobank may aid in the elucidation of the disease pathways...

  • Article
  • Open Access
5,222 Views
14 Pages

The Co-Localization of NLRP3 and ASC Specks Does Not Automatically Entail NLRP3 Inflammasome Functionality in PDAC Cell Lines

  • Heléne Lindholm,
  • Matthew Herring,
  • Maria Faresjö,
  • Johan Haux and ,
  • Ferenc Szekeres and
  • Katarina Ejeskär
  • + 1 author+ 0 author

The NLRP3 inflammasome is an important mediator of the host inflammatory response, and downregulation of inflammation is important in cancer treatment. Here, we investigated four different pancreatic ductal adenocarcinoma (PDAC) cell lines, AsPC-1, B...

  • Article
  • Open Access
4 Citations
6,672 Views
16 Pages

The liver is structurally organized into zonation, where Liver Sinusoidal Endothelial Cells (LSECs) play a crucial role during chronic liver injury and the early stages of fibrosis. Fibrosis can be reversed if diagnosed early at the molecular level i...

(This article belongs to the Collection Feature Papers in International Journal of Translational Medicine)
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Int. J. Transl. Med. - ISSN 2673-8937