You are currently viewing a new version of our website. To view the old version click .

Bioengineering, Volume 7, Issue 2

June 2020 - 33 articles

Cover Story: During the wound repair process, tissue integrity is dynamically changed from broken loose to healed dense tissue. In this study, we investigate the role of tissue density in the modulation of macrophage phenotypes and their cellular functions in 3D biomimetic matrix models. From our findings, it is clear that matrix density affects the traits of macrophages. Our matrix models will pave the way for novel therapeutic strategies for improving wound repair and can guide design of biomaterials for immuno-modulation. The balance of macrophage phenotypes determines their function and ultimately wound repair outcome, resolution, or chronic. This is depicted through our Yin and Yang-inspired cover image, implying that macrophage phenotype is not absolute and static, but is dynamic and the phenotype balance can be skewed externally, modulated through tissue density. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (33)

  • Article
  • Open Access
1 Citations
5,064 Views
14 Pages

An Uncertainty Modeling Framework for Intracardiac Electrogram Analysis

  • Amirhossein Koneshloo,
  • Dongping Du and
  • Yuncheng Du

Intracardiac electrograms (EGMs) are electrical signals measured within the chambers of the heart, which can be used to locate abnormal cardiac tissue and guide catheter ablations to treat cardiac arrhythmias. EGMs may contain large amounts of uncert...

  • Communication
  • Open Access
20 Citations
4,690 Views
11 Pages

The Process of Producing Bioethanol from Delignified Cellulose Isolated from Plants of the Miscanthus Genus

  • Olga Kriger,
  • Ekaterina Budenkova,
  • Olga Babich,
  • Stanislav Suhih,
  • Nikolay Patyukov,
  • Yakov Masyutin,
  • Vyacheslav Dolganuk and
  • Evgeny Chupakhin

Plants of the Miscanthus genus (Miscanthus Anderss.) have a unique index of biomass production in relation to the occupied area. Miscanthus plants can be attributed to promising second-generation raw materials for the production of bioethanol and bio...

  • Article
  • Open Access
17 Citations
5,696 Views
21 Pages

A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets

  • Luke T. Hudson,
  • Samuel V. Jett,
  • Katherine E. Kramer,
  • Devin W. Laurence,
  • Colton J. Ross,
  • Rheal A. Towner,
  • Ryan Baumwart,
  • Ki Moo Lim,
  • Arshid Mir and
  • Harold M. Burkhart
  • + 2 authors

The tricuspid valve (TV) is composed of three leaflets that coapt during systole to prevent deoxygenated blood from re-entering the right atrium. The connection between the TV leaflets’ microstructure and the tissue-level mechanical responses h...

  • Article
  • Open Access
35 Citations
6,777 Views
27 Pages

Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro

  • Daria S. Chulpanova,
  • Valeriya V. Solovyeva,
  • Victoria James,
  • Svetlana S. Arkhipova,
  • Marina O. Gomzikova,
  • Ekaterina E. Garanina,
  • Elvira R. Akhmetzyanova,
  • Leysan G. Tazetdinova,
  • Svetlana F. Khaiboullina and
  • Albert A. Rizvanov

High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating...

  • Article
  • Open Access
17 Citations
6,091 Views
13 Pages

Complex Geometry Cellulose Hydrogels Using a Direct Casting Method

  • Hossein Najaf Zadeh,
  • Tim Huber,
  • Volker Nock,
  • Conan Fee and
  • Don Clucas

To facilitate functional hydrogel part production using the indirect wax mould method, it is necessary to understand the relationships between materials, process and mould removal. This research investigated the thermophysical properties, wettability...

  • Article
  • Open Access
12 Citations
6,425 Views
16 Pages

Modulation of the Microtubule Network for Optimization of Nanoparticle Dynamics for the Advancement of Cancer Nanomedicine

  • Aaron Bannister,
  • Dushanthi Dissanayake,
  • Antonia Kowalewski,
  • Leah Cicon,
  • Kyle Bromma and
  • Devika B. Chithrani

Nanoparticles (NPs) have shown promise in both radiotherapy and chemotherapy. NPs are mainly transported along cellular microtubules (MTs). Docetaxel (DTX) is a commonly used chemotherapeutic drug that can manipulate the cellular MT network to maximi...

  • Article
  • Open Access
5 Citations
8,058 Views
20 Pages

Pseudopterosin and O-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma

  • Bailu Xie,
  • Jan Hänsel,
  • Vanessa Mundorf,
  • Janina Betz,
  • Irene Reimche,
  • Mert Erkan,
  • Ibrahim Büdeyri,
  • Anne Gesell,
  • Russell G. Kerr and
  • Ni Putu Ariantari
  • + 4 authors

Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in vitro model...

  • Article
  • Open Access
61 Citations
7,360 Views
13 Pages

Extraction of teeth is an important treatment decision in orthodontic practice. An expert system that is able to arrive at suitable treatment decisions can be valuable to clinicians for verifying treatment plans, minimizing human error, training orth...

  • Article
  • Open Access
32 Citations
6,903 Views
15 Pages

An Analysis of the Effects of Noisy Electrocardiogram Signal on Heartbeat Detection Performance

  • Ziti Fariha Mohd Apandi,
  • Ryojun Ikeura,
  • Soichiro Hayakawa and
  • Shigeyoshi Tsutsumi

Heartbeat detection for ambulatory cardiac monitoring is more challenging as the level of noise and artefacts induced by daily-life activities are considerably higher than monitoring in a hospital setting. It is valuable to understand the relationshi...

  • Article
  • Open Access
35 Citations
6,117 Views
10 Pages

In this work, Andean sacha inchi (Plukenetia volubilis L.) leaves were used to prepare monodispersed cuprous oxide (Cu2O) nanoparticles under heating. Visual color changes and UV-visible spectroscopy of colloidal nanoparticles showed λmax at 2...

of 4

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Bioengineering - ISSN 2306-5354