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Bioengineering, Volume 7, Issue 3

September 2020 - 54 articles

Cover Story: Using a 3D fibrin matrix model, corneal fibroblasts have been shown to secrete, bind, and organize fibronectin into tracks that facilitate cell spreading and migration. Here, we demonstrate that during fibroblast spreading, fibronectin is organized in coordination with the compaction and realignment of fibrin fibers by cellular traction forces. Over time, this leads to the formation of an interconnected network of cells, fibronectin, and compacted fibrin tracks. Interestingly, interconnected networks of fibroblasts are often observed during in vivo corneal wound healing, and it is hypothesized that these networks may facilitate more efficient wound repopulation and closure. View this paper
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Articles (54)

  • Article
  • Open Access
7 Citations
4,639 Views
12 Pages

A Small Study of Bacterial Contamination of Anaerobic Digestion Materials and Survival in Different Feed Stocks

  • Lauren Russell,
  • Paul Whyte,
  • Annetta Zintl,
  • Stephen Gordon,
  • Bryan Markey,
  • Theo de Waal,
  • Enda Cummins,
  • Stephen Nolan,
  • Vincent O’Flaherty and
  • Florence Abram
  • + 3 authors

If pathogens are present in feedstock materials and survive in anaerobic digestion (AD) formulations at 37 °C, they may also survive the AD process to be disseminated in digestate spread on farmland as a fertilizer. The aim of this study was to i...

  • Review
  • Open Access
118 Citations
24,443 Views
40 Pages

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

  • Patrick Bédard,
  • Sara Gauvin,
  • Karel Ferland,
  • Christophe Caneparo,
  • Ève Pellerin,
  • Stéphane Chabaud and
  • Stéphane Bolduc

Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal models and e...

  • Article
  • Open Access
29 Citations
7,906 Views
18 Pages

In vitro adipose tissue models can be used to provide insight into fundamental aspects of adipose physiology. These systems may serve as replacements for animal models, which are often poor predictors of obesity and metabolic diseases in humans. Adip...

  • Review
  • Open Access
72 Citations
14,067 Views
27 Pages

Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption

  • Vanessa Allwardt,
  • Alexander J. Ainscough,
  • Priyalakshmi Viswanathan,
  • Stacy D. Sherrod,
  • John A. McLean,
  • Malcolm Haddrick and
  • Virginia Pensabene

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human tria...

  • Article
  • Open Access
34 Citations
15,614 Views
20 Pages

Biomimetic 3D Models for Investigating the Role of Monocytes and Macrophages in Atherosclerosis

  • Anna Garcia-Sabaté,
  • Walaa Kamal E. Mohamed,
  • Jiranuwat Sapudom,
  • Aseel Alatoom,
  • Layla Al Safadi and
  • Jeremy C. M. Teo

Atherosclerosis, the inflammation of artery walls due to the accumulation of lipids, is the most common underlying cause for cardiovascular diseases. Monocytes and macrophages are major cells that contribute to the initiation and progression of ather...

  • Review
  • Open Access
49 Citations
7,796 Views
16 Pages

Biomimetic Nanocarriers for Cancer Target Therapy

  • Clara Guido,
  • Gabriele Maiorano,
  • Barbara Cortese,
  • Stefania D’Amone and
  • Ilaria Elena Palamà

Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsiv...

  • Article
  • Open Access
19 Citations
5,726 Views
12 Pages

Elastin-Collagen Based Hydrogels as Model Scaffolds to Induce Three-Dimensional Adipocyte Culture from Adipose Derived Stem Cells

  • Kristen Newman,
  • Kendra Clark,
  • Bhuvaneswari Gurumurthy,
  • Pallabi Pal and
  • Amol V. Janorkar

This study aimed to probe the effect of formulation of scaffolds prepared using collagen and elastin-like polypeptide (ELP) and their resulting physico-chemical and mechanical properties on the adipogenic differentiation of human adipose derived stem...

  • Article
  • Open Access
2 Citations
4,553 Views
10 Pages

SlicerArduino: A Bridge between Medical Imaging Platform and Microcontroller

  • Paolo Zaffino,
  • Alessio Merola,
  • Domenico Leuzzi,
  • Virgilio Sabatino,
  • Carlo Cosentino and
  • Maria Francesca Spadea

Interaction between medical image platform and external environment is a desirable feature in several clinical, research, and educational scenarios. In this work, the integration between 3D Slicer package and Arduino board is introduced, enabling a s...

  • Review
  • Open Access
8 Citations
4,865 Views
16 Pages

Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential

  • Richard E. Decker,
  • Zachary E. Lamantia,
  • Todd S. Emrick and
  • Marxa L. Figueiredo

There are currently multiple approaches to facilitate gene therapy via intramuscular gene delivery, such as electroporation, viral delivery, or direct DNA injection with or without polymeric carriers. Each of these methods has benefits, but each meth...

  • Article
  • Open Access
48 Citations
8,751 Views
12 Pages

Layer-by-layer additive manufacturing process has evolved into three-dimensional (3D) “bio-printing” as a means of constructing cell-laden functional tissue equivalents. The process typically involves the mixing of cells of interest with...

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Bioengineering - ISSN 2306-5354