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Bioengineering, Volume 7, Issue 1

March 2020 - 29 articles

Cover Story: Mechanical environments surrounding cancer cells, which include stiffness of the extracellular matrix, are altered during tumor progression and influence cell behaviors. In this study, we show that stiff matrices, through activation of the mechanotransducer YAP, increase the expression of MMP24, which encodes the membrane-type matrix metaroprotease-24. In addition, based on the human protein atlas database, high MMP24 expression is correlated with the prolonged overall survival rate of patients for several cancers, including breast cancer. View this paper.
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Articles (29)

  • Article
  • Open Access
34 Citations
10,390 Views
22 Pages

PHA Production and PHA Synthases of the Halophilic Bacterium Halomonas sp. SF2003

  • Tatiana Thomas,
  • Kumar Sudesh,
  • Alexis Bazire,
  • Anne Elain,
  • Hua Tiang Tan,
  • Hui Lim and
  • Stéphane Bruzaud

Among the different tools which can be studied and managed to tailor-make polyhydroxyalkanoates (PHAs) and enhance their production, bacterial strain and carbon substrates are essential. The assimilation of carbon sources is dependent on bacterial st...

  • Article
  • Open Access
5 Citations
7,337 Views
29 Pages

Biomechanical Behavior of a Variable Angle Locked Tibiotalocalcaneal Construct

  • Farah Hamandi,
  • Gerard Simon,
  • Richard Laughlin and
  • Tarun Goswami

This paper examines the mechanics of the tibiotalocalcaneal construct made with a PHILOS plating system. A failed device consisting of the LCP plate and cortical, locking, and cannulated screws was used to perform the analysis. Visual, microstructure...

  • Article
  • Open Access
9 Citations
6,511 Views
13 Pages

Low Temperature Dissolution of Yeast Chitin-Glucan Complex and Characterization of the Regenerated Polymer

  • Diana Araújo,
  • Vítor D. Alves,
  • Ana C. Marques,
  • Elvira Fortunato,
  • Maria A. M. Reis and
  • Filomena Freitas

Chitin-glucan complex (CGC) is a copolymer composed of chitin and glucan moieties extracted from the cell-walls of several yeasts and fungi. Despite its proven valuable properties, that include antibacterial, antioxidant and anticancer activity, the...

  • Article
  • Open Access
52 Citations
7,068 Views
12 Pages

Biogenic Ceria Nanoparticles (CeO2 NPs) for Effective Photocatalytic and Cytotoxic Activity

  • Siripireddy Balaji,
  • Badal Kumar Mandal,
  • L. Vinod Kumar Reddy and
  • Dwaipayan Sen

Ceria nanoparticles (CeO2 NPs) are generally considered in various functional applications, such as catalysts in fuel cells, sensors, and antioxidant and oxidase-like enzymes in the biological environment. The CeO2 NPs were synthesized using the E. g...

  • Review
  • Open Access
19 Citations
10,125 Views
15 Pages

Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

  • Colton J. Ross,
  • Junnan Zheng,
  • Liang Ma,
  • Yi Wu and
  • Chung-Hao Lee

The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary mu...

  • Editorial
  • Open Access
23 Citations
7,669 Views
6 Pages

During the two years that have passed since the first volume of “Advances in Polyhydroxyalkanoate (PHA) production” was published, the progress in PHA-related research was indeed tremendous, calling for the next, highly bioprocess- and bi...

  • Article
  • Open Access
6 Citations
6,620 Views
16 Pages

Neural Modulation of the Primary Auditory Cortex by Intracortical Microstimulation with a Bio-Inspired Electronic System

  • Maria Giovanna Bianco,
  • Salvatore Andrea Pullano,
  • Rita Citraro,
  • Emilio Russo,
  • Giovambattista De Sarro,
  • Etienne de Villers Sidani and
  • Antonino S. Fiorillo

Nowadays, the majority of the progress in the development of implantable neuroprostheses has been achieved by improving the knowledge of brain functions so as to restore sensorial impairments. Intracortical microstimulation (ICMS) is a widely used te...

  • Review
  • Open Access
17 Citations
9,038 Views
16 Pages

Background: The healing of long bones diaphyseal fractures can be often impaired and eventually end into delayed union and non-union. A number of therapeutic strategies have been proposed in combination with surgical treatment in order to enhance the...

  • Article
  • Open Access
29 Citations
7,551 Views
11 Pages

Electrospinning Live Cells Using Gelatin and Pullulan

  • Nasim Nosoudi,
  • Anson Jacob Oommen,
  • Savannah Stultz,
  • Micah Jordan,
  • Seba Aldabel,
  • Chandra Hohne,
  • James Mosser,
  • Bailey Archacki,
  • Alliah Turner and
  • Paul Turner

Electrospinning is a scaffold production method that utilizes electric force to draw a polymer solution into nanometer-sized fibers. By optimizing the polymer and electrospinning parameters, a scaffold is created with the desired thickness, alignment...

  • Article
  • Open Access
24 Citations
7,787 Views
14 Pages

Thauera aminoaromatica MZ1T Identified as a Polyhydroxyalkanoate-Producing Bacterium within a Mixed Microbial Consortium

  • Dana I. Colpa,
  • Wen Zhou,
  • Jan Pier Wempe,
  • Jelmer Tamis,
  • Marc C. A. Stuart,
  • Janneke Krooneman and
  • Gert-Jan W. Euverink

Polyhydroxyalkanoates (PHAs) form a highly promising class of bioplastics for the transition from fossil fuel-based plastics to bio-renewable and biodegradable plastics. Mixed microbial consortia (MMC) are known to be able to produce PHAs from organi...

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Bioengineering - ISSN 2306-5354