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Medicines, Volume 5, Issue 4

December 2018 - 29 articles

Cover Story: This review reports the advantages of nano-delivery systems, which have been developed to protect the curcumin substance from degradation and improve its bioavailability. Curcumin is a natural polyphenolic compound from the root of Curcuma Longa L. Its consumption as a nutraceutical increases because of its antioxidant and anti-inflammatory properties. Several in vitro and in vivo studies have demonstrated the neuroprotective potential of curcumin in different neurodegenerative disease models. Curcumin has limited water-solubility, which presents obstacles for successful clinical trials with Alzheimer’s disease patients. Therefore, the considered here lipid-based nanoparticles and polymeric carriers offer new opportunities for curcumin delivery and enhancing its bioavailiability in pharmaceutical applications. View this paper.
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Articles (29)

  • Article
  • Open Access
16 Citations
5,327 Views
9 Pages

A New Approach for Indexing Honey for Its Heath/Medicinal Benefits: Visualization of the Concept by Indexing Based on Antioxidant and Antibacterial Activities

  • Mahmud Masalha,
  • Saleh Abu-Lafi,
  • Basheer Abu-Farich,
  • Mahmoud Rayan,
  • Nael Issa,
  • Mouhammad Zeidan and
  • Anwar Rayan

17 December 2018

Background: The goals of the current study were to address a new concept termed a health benefits’ index (HBI) and to verify the type of correlation between the pricing of honey and its HBI/medicinal properties. Diverse types of honey from diff...

  • Article
  • Open Access
15 Citations
7,679 Views
10 Pages

16 December 2018

Background: The parents of preterm infants face major mental health challenges in the Neonatal Intensive Care Unit (NICU). Family-centered music therapy actively integrates and empowers parents in their infants’ care. With the aim to better und...

  • Article
  • Open Access
10 Citations
4,492 Views
13 Pages

Knockdown of Gene Expression in Macrophages by microRNA Mimic-Containing Poly (Lactic-co-glycolic Acid) Microparticles

  • Paul J. McKiernan,
  • Patrick Lynch,
  • Joanne M. Ramsey,
  • Sally Ann Cryan and
  • Catherine M. Greene

15 December 2018

Background: microRNA (miRNA) regulate target gene expression through translational repression and/or mRNA degradation and are involved in the regulation of inflammation. Macrophages are key inflammatory cells that are important in chronic inflammator...

  • Editorial
  • Open Access
9 Citations
12,690 Views
5 Pages

12 December 2018

This editorial describes a new hypothesis concerning the nature and possible mechanisms of the Nogier reflex or reflex auriculo-cardiac (RAC; also vascular autonomic signal VAS). A multimodal concept for future RAC research is proposed.

  • Review
  • Open Access
51 Citations
10,473 Views
12 Pages

11 December 2018

The fields of radiotherapy and clinical oncology have been rapidly changed by the advances of technology. Improvement in computer processing power and imaging quality heralded precision radiotherapy allowing radiotherapy to be delivered efficiently,...

  • Review
  • Open Access
14 Citations
7,843 Views
12 Pages

Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis

  • Masataka Sunagawa,
  • Kojiro Yamaguchi,
  • Mana Tsukada,
  • Nachi Ebihara,
  • Hideshi Ikemoto and
  • Tadashi Hisamitsu

10 December 2018

Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and t...

  • Article
  • Open Access
12 Citations
5,021 Views
9 Pages

3 December 2018

Background: The genera Abiotrophia and Granulicatella, previously known as nutritionally variant streptococci (NVS), are fastidious bacteria requiring vitamin B6 analogs for growth. They are members of human normal oral microbiota, and are supposed t...

  • Article
  • Open Access
11 Citations
4,609 Views
10 Pages

Association of Dietary Advanced Glycation End Products with Metabolic Syndrome in Young Mexican Adults

  • Kenny Mendoza-Herrera,
  • Celia Aradillas-García,
  • Miguel A. Mejía-Diaz,
  • Jorge A. Alegría-Torres,
  • Ma. Eugenia Garay-Sevilla and
  • Claudia Luevano-Contreras

1 December 2018

Background: Consumption of dietary advanced glycation end products is linked to metabolic syndrome. The objective was to describe the association between dietary advanced glycation end products intake and metabolic syndrome in young Mexican adults. M...

  • Review
  • Open Access
64 Citations
8,012 Views
21 Pages

23 November 2018

Neurodegenerative diseases have become a major challenge for public health because of their incurable status. Soft nanotechnology provides potential for slowing down the progression of neurodegenerative disorders by using innovative formulations of n...

  • Review
  • Open Access
47 Citations
10,933 Views
13 Pages

23 November 2018

Nelumbo nucifera Gaertn. has been used as an important ingredient for traditional medicines since ancient times, especially in Asian countries. Nowadays, many new or unknown phytochemical compounds from N. nucifera are still being discovered. Most of...

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Medicines - ISSN 2305-6320