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Scabiosa Genus: A Rich Source of Bioactive Metabolites

Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810193 Aveiro, Portugal
Unité de Recherche et Valorisation des Ressources Naturelles, Molécules Bioactives et Analyse Physico-Chimiques et Biologiques, Université des Frères Mentouri Constantine 1, Constantine, Algérie
Author to whom correspondence should be addressed.
Medicines 2018, 5(4), 110;
Received: 17 September 2018 / Revised: 2 October 2018 / Accepted: 6 October 2018 / Published: 9 October 2018
(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
PDF [2414 KB, uploaded 12 October 2018]


The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and some Scabiosa species are used in traditional medicine systems. For instance, Scabiosa columbaria L. is used traditionally against diphtheria while S. comosa Fisch. Ex Roem. and Schult. is used in Mongolian and Tibetan traditional medical settings to treat liver diseases. The richness of Scabiosa species in secondary metabolites such as iridoids, flavonoids and pentacyclic triterpenoids may contribute to its use in folk medicine. Details on the most recent and relevant pharmacological in vivo studies on the bioactive secondary metabolites isolated from Scabiosa species will be summarized and thoroughly discussed. View Full-Text
Keywords: Scabiosa; flavonoids; iridoids; pentacyclic triterpenoids; antioxidant; anti-inflammatory; antibacterial; anticancer Scabiosa; flavonoids; iridoids; pentacyclic triterpenoids; antioxidant; anti-inflammatory; antibacterial; anticancer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pinto, D.C.G.A.; Rahmouni, N.; Beghidja, N.; Silva, A.M.S. Scabiosa Genus: A Rich Source of Bioactive Metabolites. Medicines 2018, 5, 110.

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