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Medicines 2018, 5(4), 107; https://doi.org/10.3390/medicines5040107

New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders

1
Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy
2
Medication Development program, NIDA-IRP, NIH/DHHS, NIDA suite 3301, Baltimore, MD 21224, USA
3
Centre of Excellence “Neurobiology of Dependence”, University of Cagliari, 09042 Monserrato, Italy
4
CNR Institute of Neuroscience – Cagliari, National Research Council, 09042 Monserrato, Italy
5
National Institute of Neuroscience (INN), University of Cagliari, 09042 Monserrato, Italy
*
Author to whom correspondence should be addressed.
Received: 7 August 2018 / Revised: 26 September 2018 / Accepted: 30 September 2018 / Published: 2 October 2018
(This article belongs to the Special Issue Cannabinoids for Medical Use)
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Abstract

Following the discovery of the endocannabinoid system and its potential as a therapeutic target for various pathological conditions, growing interest led researchers to investigate the role of cannabis and its derivatives for medical purposes. The compounds Δ9-tetrahydrocannabinol and cannabidiol are the most abundant phytocannabinoids found in cannabis extracts, as well as the most studied. The present review aims to provide an overview of the current evidence for their beneficial effects in treating psychiatric disorders, including schizophrenia, anxiety, and depression. Nevertheless, further investigations are required to clarify many pending issues, especially those relative to the assessment of benefits and risks when using cannabis for therapeutic purposes, thereby also helping national and federal jurisdictions to remain updated. View Full-Text
Keywords: phytocannabinoids; Δ9-tetrahydrocannabinol; cannabidiol; psychiatric disorders phytocannabinoids; Δ9-tetrahydrocannabinol; cannabidiol; psychiatric disorders
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Scherma, M.; Masia, P.; Deidda, M.; Fratta, W.; Tanda, G.; Fadda, P. New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders. Medicines 2018, 5, 107.

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