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Processes, Volume 6, Issue 5

May 2018 - 24 articles

Cover Story: The prognosis is grim for patients who have metastasis, where cancer cells spread from a localized tumor to other regions in the body. Cancer cells and the surrounding extracellular matrix (ECM) interact to facilitate migration of cancer cells during early metastasis. Cancer cells secrete particular enzymes to cut and align collagen fibers of the ECM. These ECM remodeling activities transform the ECM from a random fiber matrix into an oriented "fibrous highway" that enhances cancer cell migration. This paper addresses remodeling of the ECM during metastasis via mathematical modeling using partial differential equations. View this paper.
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Articles (24)

  • Article
  • Open Access
23 Citations
7,578 Views
21 Pages

22 May 2018

Critical infrastructure such as power and water delivery is growing rapidly in the developing world and there are developed assets that must be maintained in developed nations. One underground component that is difficult to inspect is water supply pi...

  • Feature Paper
  • Article
  • Open Access
2 Citations
5,457 Views
22 Pages

21 May 2018

Due to insufficient endogenous production of erythropoietin, chronic kidney disease patients with anemia are often treated by the administration of recombinant human erythropoietin (EPO). The target of the treatment is to keep the patient’s hemoglobi...

  • Article
  • Open Access
49 Citations
9,219 Views
14 Pages

A Facile Synthesis of Hexagonal Spinel λ-MnO2 Ion-Sieves for Highly Selective Li+ Adsorption

  • Fan Yang,
  • Sichong Chen,
  • Chentao Shi,
  • Feng Xue,
  • Xiaoxian Zhang,
  • Shengui Ju and
  • Weihong Xing

17 May 2018

Ion-sieves are a class of green adsorbent for extraction Li+ from salt lakes. Here, we propose a facile synthesis of hexagonal spinel LiMn2O4 (LMO) precursor under mild condition which was first prepared via a modified one-pot reduction hydrothermal...

  • Article
  • Open Access
29 Citations
7,259 Views
17 Pages

16 May 2018

Medical data classification is an important factor in improving diagnosis and treatment and can assist physicians in making decisions about serious diseases by collecting symptoms and medical analyses. In this work, hybrid classification optimization...

  • Feature Paper
  • Article
  • Open Access
21 Citations
11,064 Views
16 Pages

16 May 2018

The spreading of cancer cells, also known as metastasis, is a lethal hallmark in cancer progression and the primary cause of cancer death. Recent cancer research has suggested that the remodeling of collagen fibers in the extracellular matrix (ECM) o...

  • Feature Paper
  • Review
  • Open Access
16 Citations
7,434 Views
23 Pages

The Spectrum of Mechanism-Oriented Models and Methods for Explanations of Biological Phenomena

  • C. Anthony Hunt,
  • Ahmet Erdemir,
  • William W. Lytton,
  • Feilim Mac Gabhann,
  • Edward A. Sander,
  • Mark K. Transtrum and
  • Lealem Mulugeta

14 May 2018

Developing and improving mechanism-oriented computational models to better explain biological phenomena is a dynamic and expanding frontier. As the complexity of targeted phenomena has increased, so too has the diversity in methods and terminologies,...

  • Review
  • Open Access
108 Citations
17,155 Views
15 Pages

12 May 2018

The growing demand for lithium necessitates the development of an efficient process to recover it from three kinds of solutions, namely brines as well as acid and alkaline leach liquors of primary and secondary resources. Therefore, the separation of...

  • Article
  • Open Access
15 Citations
5,671 Views
14 Pages

11 May 2018

The ampholytic chitosan based flocculant carboxylated chitosan graft-(3-chloro-2-hydroxypropyl) trimethylammonium chloride-dimethyl diallyl ammonium chloride (CPCTS-g-P (CTA-DMDAAC)) was synthesized by photo polymerization using carboxylated chitosan...

  • Feature Paper
  • Article
  • Open Access
21 Citations
13,906 Views
21 Pages

A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line

  • Huiyi Cao,
  • Srinivas Mushnoori,
  • Barry Higgins,
  • Chandrasekhar Kollipara,
  • Adam Fermier,
  • Douglas Hausner,
  • Shantenu Jha,
  • Ravendra Singh,
  • Marianthi Ierapetritou and
  • Rohit Ramachandran

10 May 2018

As the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and inte...

  • Feature Paper
  • Article
  • Open Access
35 Citations
8,209 Views
26 Pages

8 May 2018

Shale gas production is associated with significant usage of fresh water and discharge of wastewater. Consequently, there is a necessity to create proper management strategies for water resources in shale gas production and to integrate conventional...

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Processes - ISSN 2227-9717