Table of Contents
Processes, Volume 6, Issue 5 (May 2018)
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Cover Story (view full-size image) The prognosis is grim for patients who have metastasis, where cancer cells spread from a localized [...] Read more. The prognosis is grim for patients who have metastasis, where cancer cells spread from a localized tumor to other regions in the body. Cancer cells and the surrounding extracellular matrix (ECM) interact to facilitate migration of cancer cells during early metastasis. Cancer cells secrete particular enzymes to cut and align collagen fibers of the ECM. These ECM remodeling activities transform the ECM from a random fiber matrix into an oriented "fibrous highway" that enhances cancer cell migration. This paper addresses remodeling of the ECM during metastasis via mathematical modeling using partial differential equations. View this paper.