Table of Contents
Biomedicines, Volume 7, Issue 1 (March 2019)
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Cover Story (view full-size image) Multiple mechanisms can explain MS progression. First, an inflammatory phenomenon compartmentalized [...] Read more. Multiple mechanisms can explain MS progression. First, an inflammatory phenomenon compartmentalized within the CNS. Cellular components are represented by both peripheral lymphocytes as well as by resident CNS cells (microglia cells and astrocytes). Second, following demyelination, energy requirements increase and the reduction in neuronal ATP production may lead to the accumulation of intra-axonal calcium, which activates degradative enzymes. Third, axonal damage can be produced by poor trophic support by the oligodendrocytes. Finally, the activation and expansion of microglia cells can contribute to axonal damage as well as the activation and proliferation of astrocytes, leading to astrogliosis. View this paper.