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Biomedicines, Volume 7, Issue 1

March 2019 - 23 articles

Cover Story: Multiple mechanisms can explain MS progression. First, an inflammatory phenomenon compartmentalized within the CNS. Cellular components are represented by both peripheral lymphocytes as well as by resident CNS cells (microglia cells and astrocytes). Second, following demyelination, energy requirements increase and the reduction in neuronal ATP production may lead to the accumulation of intra-axonal calcium, which activates degradative enzymes. Third, axonal damage can be produced by poor trophic support by the oligodendrocytes. Finally, the activation and expansion of microglia cells can contribute to axonal damage as well as the activation and proliferation of astrocytes, leading to astrogliosis. View this paper.
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Articles (23)

  • Review
  • Open Access
306 Citations
26,421 Views
16 Pages

Zebrafish Larvae as a Behavioral Model in Neuropharmacology

  • Ram Manohar Basnet,
  • Daniela Zizioli,
  • Somrat Taweedet,
  • Dario Finazzi and
  • Maurizio Memo

Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark conditions, following the development of a swim bladder at 4 days post fertilization. This swimming behavior is increasingly employed in the screening of neu...

  • Article
  • Open Access
4 Citations
6,751 Views
17 Pages

Calcium Carbonate Nanoparticles Can Activate the Epithelial–Mesenchymal Transition in an Experimental Gastric Cancer Model

  • Marina Senchukova,
  • Olesya Tomchuk,
  • Elena Shurygina,
  • Sergey Letuta,
  • Eskender Alidzhanov,
  • Hike Nikiyan and
  • Dmitry Razdobreev

Previously, we have shown the possibility of intramucosal gastric carcinoma induction by the intragastric administration of a mixture of formaldehyde and hydrogen peroxide in rats. In this study, we report a sizable increase in carcinogenic propertie...

  • Review
  • Open Access
104 Citations
12,113 Views
19 Pages

Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present early in the course of the disease and has an impact on a patient’s employability, social interactions, and quality of life. In the last three deca...

  • Review
  • Open Access
52 Citations
16,915 Views
13 Pages

The global incidence of multiple sclerosis (MS) appears to be increasing. Although it may not be associated with a high mortality rate, this disease has a high morbidity rate which affects the quality of life of patients and reduces their ability to...

  • Review
  • Open Access
34 Citations
12,554 Views
15 Pages

Current Knowledge of IL-6 Cytokine Family Members in Acute and Chronic Kidney Disease

  • Aaron L. Magno,
  • Lakshini Y. Herat,
  • Revathy Carnagarin,
  • Markus P. Schlaich and
  • Vance B. Matthews

Healthy kidneys are important for the efficient regulation of metabolism. However, there is an ever increasing population of patients suffering from both acute and chronic kidney diseases that disrupt this homeostasis. This review will explore the em...

  • Review
  • Open Access
49 Citations
10,379 Views
19 Pages

Daclizumab (DAC) is a humanized, monoclonal antibody that blocks CD25, a critical element of the high-affinity interleukin-2 receptor (IL-2R). DAC HYP blockade of CD25 inhibits effector T cell activation, regulatory T cell expansion and survival, and...

  • Review
  • Open Access
34 Citations
5,399 Views
9 Pages

Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth...

  • Review
  • Open Access
39 Citations
33,704 Views
31 Pages

Millions of people around the world drink alcoholic beverages to cope with the stress of modern lifestyle. Although moderate alcohol drinking may have some relaxing and euphoric effects, uncontrolled drinking exacerbates the problems associated with...

  • Review
  • Open Access
62 Citations
10,417 Views
16 Pages

On Zebrafish Disease Models and Matters of the Heart

  • Panagiota Giardoglou and
  • Dimitris Beis

Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is the primary cause of mortality worldwide. It is a complex disease with genetic and environmental risk factor contributions. Reports in human and mammalian mod...

  • Review
  • Open Access
127 Citations
16,284 Views
23 Pages

Mechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis

  • Jorge Correale,
  • Mariano Marrodan and
  • María Célica Ysrraelit

Multiple Sclerosis (MS) is a major cause of neurological disability, which increases predominantly during disease progression as a result of cortical and grey matter structures involvement. The gradual accumulation of disability characteristic of the...

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Biomedicines - ISSN 2227-9059