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On Zebrafish Disease Models and Matters of the Heart

1
Zebrafish Disease Models Lab, Center for Clinical Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece
2
School of Health Science and Education, Harokopio University, 17676 Athens, Greece
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(1), 15; https://doi.org/10.3390/biomedicines7010015
Received: 25 January 2019 / Revised: 23 February 2019 / Accepted: 26 February 2019 / Published: 28 February 2019
(This article belongs to the Special Issue Zebrafish Models for Development and Disease)
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Abstract

Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is the primary cause of mortality worldwide. It is a complex disease with genetic and environmental risk factor contributions. Reports in human and mammalian models elucidate age-associated changes in cardiac function. The diverse mechanisms involved in cardiac diseases remain at the center of the research interest to identify novel strategies for prevention and therapy. Zebrafish (Danio rerio) have emerged as a valuable vertebrate model to study cardiovascular development over the last few decades. The facile genetic manipulation via forward and reverse genetic approaches combined with noninvasive, high-resolution imaging and phenotype-based screening has provided new insights to molecular pathways that orchestrate cardiac development. Zebrafish can recapitulate human cardiac pathophysiology due to gene and regulatory pathways conservation, similar heart rate and cardiac morphology and function. Thus, generations of zebrafish models utilize the functional analysis of genes involved in CAD, which are derived from large-scale human population analysis. Here, we highlight recent studies conducted on cardiovascular research focusing on the benefits of the combination of genome-wide association studies (GWAS) with functional genomic analysis in zebrafish. We further summarize the knowledge obtained from zebrafish studies that have demonstrated the architecture of the fundamental mechanisms underlying heart development, homeostasis and regeneration at the cellular and molecular levels. View Full-Text
Keywords: cardiovascular development; genetic manipulation; phenotype screening; genome-wide association studies; functional analysis cardiovascular development; genetic manipulation; phenotype screening; genome-wide association studies; functional analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Giardoglou, P.; Beis, D. On Zebrafish Disease Models and Matters of the Heart. Biomedicines 2019, 7, 15.

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