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Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview

Department of Neurosciences, CUCS. University of Guadalajara and Mexico, Guadalajara 44160, Mexico
Neurology, Pontificia Universidad Católica de Chile, Neurology, Hospital Dr. Sótero del Río, Santiago 8320000, Chile
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(1), 22;
Received: 11 January 2019 / Revised: 13 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Multiple Sclerosis: Diagnosis and Treatment)
PDF [7760 KB, uploaded 19 March 2019]


Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present early in the course of the disease and has an impact on a patient’s employability, social interactions, and quality of life. In the last three decades, an increasing interest in diagnosis and management of cognitive impairment has arisen. Neuropsychological assessment and neuroimaging studies focusing on cognitive impairment are now being incorporated as primary outcomes in clinical trials. However, there are still key uncertainties concerning the underlying mechanisms of damage, neural basis, sensitivity and validity of neuropsychological tests, and efficacy of pharmacological and non-pharmacological interventions. The present article aimed to present an overview of the assessment, neural correlates, and impact of cognitive impairment in multiple sclerosis. View Full-Text
Keywords: multiple sclerosis; demyelinating diseases; cognitive impairment; cognitive dysfunction multiple sclerosis; demyelinating diseases; cognitive impairment; cognitive dysfunction

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Macías Islas, M.Á.; Ciampi, E. Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview. Biomedicines 2019, 7, 22.

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