Next Article in Journal
Zebrafish Larvae as a Behavioral Model in Neuropharmacology
Next Article in Special Issue
Stem Cell-Based Therapies for Multiple Sclerosis: Current Perspectives
Previous Article in Journal
Calcium Carbonate Nanoparticles Can Activate the Epithelial–Mesenchymal Transition in an Experimental Gastric Cancer Model
Previous Article in Special Issue
Monoclonal Antibodies in Multiple Sclerosis: Present and Future
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview

Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview

1
Department of Neurosciences, CUCS. University of Guadalajara and Mexico, Guadalajara 44160, Mexico
2
Neurology, Pontificia Universidad Católica de Chile, Neurology, Hospital Dr. Sótero del Río, Santiago 8320000, Chile
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(1), 22; https://doi.org/10.3390/biomedicines7010022
Received: 11 January 2019 / Revised: 13 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Multiple Sclerosis: Diagnosis and Treatment)
  |  
PDF [7760 KB, uploaded 19 March 2019]
  |  

Abstract

Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present early in the course of the disease and has an impact on a patient’s employability, social interactions, and quality of life. In the last three decades, an increasing interest in diagnosis and management of cognitive impairment has arisen. Neuropsychological assessment and neuroimaging studies focusing on cognitive impairment are now being incorporated as primary outcomes in clinical trials. However, there are still key uncertainties concerning the underlying mechanisms of damage, neural basis, sensitivity and validity of neuropsychological tests, and efficacy of pharmacological and non-pharmacological interventions. The present article aimed to present an overview of the assessment, neural correlates, and impact of cognitive impairment in multiple sclerosis. View Full-Text
Keywords: multiple sclerosis; demyelinating diseases; cognitive impairment; cognitive dysfunction multiple sclerosis; demyelinating diseases; cognitive impairment; cognitive dysfunction
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Macías Islas, M.Á.; Ciampi, E. Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: An Overview. Biomedicines 2019, 7, 22.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top