- Editorial
252 Views
4 Pages
Environmental Exposures and Human Diseases: Molecular Insights
- Maaike van Gerwen,
- Luoping Zhang and
- Angela M. Leung
Environmental exposures play an important role in the development of diseases [...]
- 3.9Impact Factor
- 6.8CiteScore
- 18 daysTime to First Decision
Biomedicines, Volume 13, Issue 11
November 2025 - 268 articles
Cover Story: mTOR is a central regulator of cellular growth and neural activity, positioned at the intersection of oncogenic signaling and neural circuit dynamics. In adult diffusely infiltrating glioma, dysregulated mTOR not only facilitates tumor proliferation and metabolism, but it also reshapes communication between tumor cells and surrounding neurons. Molecular, electrophysiological, and imaging studies reveal that mTOR-dependent signaling drives synaptic remodeling, alters excitatory–inhibitory balance, and increases network hyperexcitability. These changes contribute to both glioma-associated seizures and cognitive decline. In this review, we highlight mTOR as a key mediator of neuron–glioma crosstalk and a potential therapeutic target capable of addressing tumor-induced neurological dysfunction in patients with glioma. View this paper
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Articles (268)
- Review
543 Views
17 Pages
Dual-Action Regenerative Therapies: Regeneration and Antimicrobial Effects of Platelet- and Marrow-Derived Biologics
- Claire Yuan,
- Samuel P. Ang,
- Jamal J. Hasoon,
- Reda Tolba,
- Qing Zhao Ruan,
- Christopher M. Lam,
- Giuliano Lo Bianco,
- Paul J. Christo and
- Christopher L. Robinson
This review explores the dual regenerative and antimicrobial properties of platelet- and marrow-derived biologics, including platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), autologous protein solutions, and plasma fractions. Thes...
- Article
497 Views
16 Pages
Age-Stratified Analysis of the Clinical Efficacy of Subcutaneous Immunotherapy for Allergic Rhinitis in Chinese Patients
- Ling Jin,
- Kai Fan,
- Shican Zhou,
- Yang Wang,
- Shiwang Tan,
- Bojin Long and
- Shaoqing Yu
Background/Objectives: To investigate the relationship between patient age and the clinical efficacy of subcutaneous immunotherapy (SCIT) for allergic rhinitis (AR), aiming to provide a reference for patient selection and efficacy improvement in clin...
- Article
392 Views
12 Pages
Evaluation of Stereopsis Performance, Gaze Direction and Pupil Diameter in Post-COVID Syndrome Using Machine Learning
- Thomas S. Knauer,
- Christian Y. Mardin,
- Jürgen Rech,
- Georg Michelson,
- Andreas Stog,
- Julia Zott,
- Fritz Steußloff,
- Moritz Güttes,
- Helena Sarmiento and
- Miriam Ilgner
- + 3 authors
Background/Objectives: Post-COVID syndrome (PCS) encompasses symptoms that persist for at least 12 weeks after the onset of a COVID-19 infection and cannot be explained by other causes. The most common symptoms are fatigue, cognitive impairments, and...
- Article
365 Views
24 Pages
Factors Released by Polarized Neutrophil-like Cells Modulate Cardiac Fibroblast Phenotype and Limit the Inflammatory Response After Myocardial Infarction
- Letitia Ciortan,
- Ana-Maria Gan,
- Sergiu Cecoltan,
- Mihaela Serbanescu,
- Andreea Cristina Mihaila,
- Razvan Daniel Macarie,
- Monica Madalina Tucureanu,
- Miruna Larisa Naie,
- Mihai Bogdan Preda and
- Bogdan-Paul Cosman
- + 3 authors
Background: Following myocardial infarction (MI), cardiac fibroblasts (CFs) adopt distinct phenotypes to ensure scar formation and healing. Although leukocytes are a critical driver of post-MI healing, the role of neutrophils in modulating CF phenoty...
- Article
312 Views
13 Pages
Potential Causal Effects of Cystatin C on Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study
- Young Lee and
- Je Hyun Seo
Background/Objectives: Previous studies have shown an association between kidney function and age-related macular degeneration (AMD). This study aims to assess whether the kidney function-related parameters of serum cystatin C and creatinine levels a...
- Article
404 Views
18 Pages
Evaluation of Thermal, Hematohistological, and Dermatological Biocompatibility of LED Devices for Neonatal Phototherapy
- Tayomara Ferreira Nascimento,
- Silvia Cristina Mangini Bocchi,
- João Cesar Lyra,
- Rodrigo Fernando Bianchi,
- Lauro de Assis Duarte Junior,
- Giselle Silveira Lacerda,
- Luciana Patrícia Fernandes Abadde,
- Noeme Sousa Rocha,
- Susana Eduardo Vieira and
- Hélio Langoni
- + 2 authors
Background/Objective: The effectiveness of blue-light phototherapy (PT) is mainly dependent on the total dose of light (time under PT and amount of skin exposed) received by infants. The primary aim of this study was the development of a novel, flexi...
- Review
472 Views
24 Pages
Mass Spectrometry for Lysine Methylation: Principles, Progress, and Prospects
- Mackenzie G. Cumming and
- Kyle K. Biggar
Lysine methylation is a regulatory post-translational modification with diverse roles across both histone and non-histone proteins. Despite its biological relevance, comprehensive characterization of lysine methylation remains analytically challengin...
- Article
257 Views
14 Pages
Relative Effects of Brachytherapy and Beam Radiation for DCIS on Subsequent Invasive Events
- Thomas J. O’Keefe,
- Nicolas D. Prionas and
- Anne M. Wallace
Background/Objectives: Patients with a diagnosis of ductal carcinoma in situ (DCIS) were poorly represented in the four trials that established the efficacy of partial relative to whole-breast irradiation. In contrast to invasive cancers, patients wi...
- Technical Note
375 Views
11 Pages
Best Practice PD-L1 Staining and Interpretation in Gastric Cancer Using PD-L1 IHC PharmDx 22C3 and PD-L1 IHC PharmDx 28-8 Assays, with Reference to Common Issues and Solutions
- Soomin Ahn,
- Inwoo Hwang,
- Yuyeon Kim,
- Somin Lee,
- Yunjoo Cho,
- So Young Kang,
- Deok Geun Kim,
- Jeeyun Lee and
- Kyoung-Mee Kim
Programmed death-ligand 1 (PD-L1) biomarker testing in gastric cancer is required to identify patients suitable for immunotherapy. However, the PD-L1 testing landscape is complex, with various PD-L1 tests available and multiple algorithms that combin...
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Biomedicines - ISSN 2227-9059