Natural Product for the Interventions of Chronic Diseases: From Source to Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 3331

Special Issue Editor

School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Interests: natural products; drug discovery; pharmacognosy; inflammation; nanotechnology

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Natural Product for the Interventions of Chronic Diseases: From Source to Therapy", invites innovative research works that bridge the gap between the natural world and therapeutic applications for chronic conditions. Chronic diseases, such as rheumatoid arthritis, diabetes, and various forms of cancer, represent a growing burden on global health. Natural products have historically provided a rich source of pharmacological agents, and their role in chronic disease intervention remains an area ripe for exploration. This issue will focus on the discovery, analysis, and application of natural compounds in the prevention and treatment of chronic diseases. Submissions should highlight advancements in the selective extraction and refinement of bioactive components, the evaluation of their therapeutic potential, and the exploration of the molecular mechanisms through which these compounds exert their effects. We welcome studies that employ state-of-the-art techniques for the identification and enhancement of the therapeutic properties of natural products, as well as research that offers insight into the pharmacodynamics and pharmacokinetics of these potential treatments. By integrating traditional understanding with modern scientific approaches, this Special Issue aims to further the development of natural products as efficacious agents in the long-term management of chronic diseases. This Special Issue only includes research “with defined molecular compound”.

Dr. Qilei Chen
Guest Editor

Manuscript Submission Information

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Keywords

  • natural products
  • chronic diseases
  • drug discovery
  • pharmacodynamics
  • pharmacokinetics
  • nanotechnology

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Published Papers (1 paper)

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Review

46 pages, 3165 KiB  
Review
Unveiling the Miracle Tree: Therapeutic Potential of Moringa oleifera in Chronic Disease Management and Beyond
by Edgar Yebran Villegas-Vazquez, Rocio Gómez-Cansino, Gabriel Marcelino-Pérez, Domingo Jiménez-López and Laura Itzel Quintas-Granados
Biomedicines 2025, 13(3), 634; https://doi.org/10.3390/biomedicines13030634 - 5 Mar 2025
Viewed by 2544
Abstract
Moringa oleifera (MO) has gained recognition as a potent natural intervention for preventing and managing chronic diseases (CDs) due to its diverse phytochemical composition and pharmacological properties. Rich in antioxidants, polyphenols, flavonoids, and glucosinolates, MO exerts anti-inflammatory, anti-hyperglycemic, cardioprotective, and anti-obesity effects. These [...] Read more.
Moringa oleifera (MO) has gained recognition as a potent natural intervention for preventing and managing chronic diseases (CDs) due to its diverse phytochemical composition and pharmacological properties. Rich in antioxidants, polyphenols, flavonoids, and glucosinolates, MO exerts anti-inflammatory, anti-hyperglycemic, cardioprotective, and anti-obesity effects. These properties make it a valuable therapeutic agent for CDs, including diabetes, cardiovascular diseases, obesity, neurodegenerative disorders, and cancer. MO’s ability to modulate oxidative stress and inflammation—key drivers of CDs—highlights its significant role in disease prevention and treatment. MO enhances insulin sensitivity, regulates lipid profiles and blood pressure, reduces inflammation, and protects against oxidative damage. MO also modulates key signaling pathways involved in cancer and liver disease prevention. Studies suggest that MO extracts possess anticancer activity by modulating apoptosis, inhibiting tumor cell proliferation, and interacting with key signaling pathways, including YAP/TAZ, Nrf2-Keap1, TLR4/NF-κB, and Wnt/β-catenin. However, challenges such as variability in bioactive compounds, taste acceptability, and inconsistent clinical outcomes limit their widespread application. While preclinical studies support its efficacy, large-scale clinical trials, standardized formulations, and advanced delivery methods are needed to optimize its therapeutic potential. MO’s multifunctional applications make it a promising and sustainable solution for combating chronic diseases, especially in resource-limited settings. Full article
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