Allergic Rhinitis: From Pathology to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 547

Special Issue Editor


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Guest Editor
1. Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 20065, China
2. Department of Allergy, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China
Interests: allergic rhinitis; allergy; immunotherapy; immune mechanisms in allergy; rhinitis biomarkers

Special Issue Information

Dear Colleagues,

We are pleased to announce a new Special Issue in Biomedicines, titled “Allergic Rhinitis: From Pathology to Novel Therapeutic Approaches”, and invite you to submit your original research or review articles to this collection.

This Special Issue aims to bridge mechanistic insights into allergic rhinitis (AR) with cutting-edge therapeutic strategies. We welcome submissions exploring topics including (but not limited to) the following: immune dysregulation and molecular pathways, driving AR pathology; biomarker discovery for diagnosis, prognosis, or treatment response prediction; novel immunotherapies; microbiome–host interactions in AR development and progression; and precision medicine approaches integrating omics technologies or AI-driven models.

Accepted papers after peer review will be published in this Open Access issue, ensuring global visibility and impact. Please let us know if you are interested in submitting work to this Special Issue.   

Prof. Dr. Shaoqing Yu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergic rhinitis
  • immunotherapy
  • immune mechanisms in allergy
  • rhinitis biomarkers

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Published Papers (1 paper)

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Research

11 pages, 1460 KiB  
Article
Interleukin-37 Suppresses the Function of Type 2 Follicular Helper T in Allergic Rhinitis
by Xi Luo, Yanhui Wen, Xiangqian Qiu, Lifeng Zhou, Qingxiang Zeng and Wenlong Liu
Biomedicines 2025, 13(5), 1263; https://doi.org/10.3390/biomedicines13051263 - 21 May 2025
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Abstract
Background: Allergic rhinitis (AR) is triggered by immunoglobulin E (IgE)-mediated immune responses to airborne allergens. Recent studies highlight the pivotal role of T follicular helper 2 (Tfh2) cells in IgE production. Interleukin-37 (IL-37) has emerged as an intrinsic modulator of innate immunity and [...] Read more.
Background: Allergic rhinitis (AR) is triggered by immunoglobulin E (IgE)-mediated immune responses to airborne allergens. Recent studies highlight the pivotal role of T follicular helper 2 (Tfh2) cells in IgE production. Interleukin-37 (IL-37) has emerged as an intrinsic modulator of innate immunity and inflammatory processes. We aimed to investigate the regulatory effect of IL-37 on Tfh2 cells in the pathogenesis of AR. Methods: Blood samples were collected from AR patients and controls. The IL-37 levels and the frequency of Tfh2 cells were detected by enzyme-linked immunosorbent assay (ELISA) and flow cytometry, respectively. The isolated Tfh2 cells were cultured or cocultured with naive B cells. The regulatory effects of IL-37 on Tfh2/B cells were assessed using ELISA, quantitative real-time polymerase chain reaction (qRT-PCR). Mouse models of ovalbumin (OVA)-induced AR were established to explore the effect of IL-37 in vivo. Results: IL-37 suppressed the production of IL-4 and IL-21 by Tfh2 cells and downregulated C-X-C chemokine receptor type 5 (CXCR5) and B-cell lymphoma 6 protein (Bcl6) mRNA expression while upregulating B lymphocyte-induced maturation protein 1 (Blimp1) and signal transducers and activators of transduction5 (STAT5) mRNA. IL-37 decreased IgE production by B cells significantly, and the addition of anti-IL-18 receptor α alleviated this effect. In mouse models, IL-37 reduced nasal rubbing, sneezing, eosinophil counts, OVA-specific IgE, and Tfh2 proportions. Conclusions: IL-37 plays a crucial role in modulating Tfh2 cell responses in AR, suggesting a potential therapeutic target for this condition. Full article
(This article belongs to the Special Issue Allergic Rhinitis: From Pathology to Novel Therapeutic Approaches)
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