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Biomedicines
Special Issues
Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches
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Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 199

Special Issue Editor

Dr. Guangtong Deng

E-Mail Website
Guest Editor
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
Interests: cell death; treatment; skin diseases; melanoma

Special Issue Information

Dear Colleagues,

The skin, the largest organ of the human body, is associated with diseases that rank first in global prevalence and third in disease burden. Advances in basic, translational, and clinical research have deepened our understanding of pathogenesis, drug development, and therapeutic strategies in the context of skin diseases. Molecular dependencies identified in these processes have enabled clinicians to refine disease classification, diagnosis, and treatment approaches, thereby advancing personalized precision medicine. However, the pathogenesis of and therapeutic strategies for skin diseases warrant further exploration. This Special Issue invites the submission of original research and review articles that focus on molecular mechanisms and therapeutic strategies, with the aim of elucidating molecular factors (including but not limited to genetic, epigenetic, signaling, metabolic, and immune-related components) and the underlying dermatological pathogenesis and developing therapeutic interventions targeting these factors. Topics of particular interest include the following:

  1. Therapeutic potential of targeting cell death pathways in skin diseases;
  2. Molecular regulatory networks in skin barrier dysfunction;
  3. Interplay between the skin microbiome and immune microenvironment;
  4. Epigenetic reprogramming in chronic inflammatory skin diseases;
  5. Metabolic adaptations in the skin tumor microenvironment;
  6. Non-histaminergic mechanisms of pruritus signaling pathways;
  7. Drug resistance mechanisms and dynamic monitoring technologies;
  8. Stem cell exhaustion mechanisms in skin aging.

We look forward to receiving your contributions to this Special Issue.

Dr. Guangtong Deng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin diseases
  • cell death
  • ferroptosis
  • cuproptosis
  • melanoma
  • cancer immunotherapy
  • psoriasis

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Published Papers (1 paper)

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Research

19 pages, 5007 KiB  
Article
Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16
by Liping Jin, Xiaowen Xie, Mi Zhang, Wu Zhu, Guanxiong Zhang and Wangqing Chen
Biomedicines 2025, 13(7), 1763; https://doi.org/10.3390/biomedicines13071763 - 18 Jul 2025
Abstract
Background: Psoriasis, an inflammatory skin disorder, involves pyroptosis—a pro-inflammatory cell death process. However, cell-specific pyroptosis dynamics and immune microenvironment interactions remain unclear. Objective: To investigate cell-type-specific pyroptosis patterns in psoriasis and their immunoregulatory mechanisms. Methods: We integrated 21 transcriptomic datasets (from 2007 to [...] Read more.
Background: Psoriasis, an inflammatory skin disorder, involves pyroptosis—a pro-inflammatory cell death process. However, cell-specific pyroptosis dynamics and immune microenvironment interactions remain unclear. Objective: To investigate cell-type-specific pyroptosis patterns in psoriasis and their immunoregulatory mechanisms. Methods: We integrated 21 transcriptomic datasets (from 2007 to 2020) obtained from the GEO database and two single-cell RNA sequencing datasets to quantify pyroptotic activity using Gene Set Variation Analysis and AUCell algorithms. Immune cell infiltration profiles were evaluated via CIBERSORT, while cell-cell communication networks were analyzed by CellChat. In vitro and in vivo experiments were performed to validate key findings. Results: Our analysis revealed that psoriasis patients exhibited significantly elevated levels of pyroptosis compared to healthy controls, with pyroptotic activity reflecting treatment responses. Notably, monocyte-derived macrophages (MDMs) in psoriatic lesions displayed markedly heightened pyroptotic activity. In vitro experiments confirmed that MDMs derived from psoriasis patients overexpressed pyroptosis-related molecules (Caspase 1 and Caspase 4) as well as pro-inflammatory cytokines (TNFα, IL6, IL1β) when compared to healthy controls. Furthermore, these cells showed increased expression of CXCL16, which might potentially activate Th17 cells through CXCR6 signaling, thereby driving skin inflammation. Inhibition of monocyte migration in an imiquimod-induced psoriasiform dermatitis model significantly alleviated skin inflammation and reduced the proportion of M1 macrophages and Th17 cells in lesional skin. Conclusions: This study revealed that MDMs in psoriatic lesions exhibited a hyperactive pyroptotic state, which contributed to disease progression through CXCL16-mediated remodeling of the immune microenvironment. These findings highlight pyroptosis as a potential therapeutic target for psoriasis. Full article
(This article belongs to the Special Issue Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches)
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