New Advances in Human Reproductive Biology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 476

Special Issue Editor

Special Issue Information

Dear Colleagues,

Reproductive biology involves the scientific study of the reproductive system. Improved understanding of reproductive biology can lead to new treatments for reproductive disorders, such as infertility.

Infertility is a challenge faced by millions of couples worldwide, and advances in IVF (in vitro fertilization) technology have been a ray of hope for many. With cutting-edge developments in 2025, it is important to understand the latest breakthroughs that are transforming assisted reproductive technology.

Increased demand for in vitro fertilization due to socio-demographic trends and supply facilitated by new technologies converged to transform the way a substantial proportion of humans reproduce.

Continuous research and development in human reproduction and its molecular mechanisms form the basis for its evolution and development.

Ultimately, this Special Issue not only aims to contribute to the existing literature but also seeks to inspire ongoing efforts to enhance the development of human reproductive biology.

Dr. Nikolaos Machairiotis
Guest Editor

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Keywords

  • gametogenesis
  • fertilization
  • egg retrieval
  • embryo implantation
  • epigenetics
  • microRNAs in fertility
  • hormonal signaling
  • stem cells and fertility
  • assisted reproductive technologies
  • molecular and polymorphism in fertility
  • reproductive health novelty

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Published Papers (1 paper)

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Research

18 pages, 575 KiB  
Article
The Molecular Landscape of Nitric Oxide in Ovarian Function and IVF Success: Bridging Redox Biology and Reproductive Outcomes
by Diamandis Athanasiou, Charalampos Voros, Ntilay Soyhan, Georgia Panagou, Maria Sakellariou, Despoina Mavrogianni, Eleni Sivylla Bikouvaraki, George Daskalakis and Kalliopi Pappa
Biomedicines 2025, 13(7), 1748; https://doi.org/10.3390/biomedicines13071748 - 17 Jul 2025
Viewed by 327
Abstract
Background: Nitric oxide (NO) is an important modulator of ovarian physiology, which contributes to angiogenesis, steroidogenesis, and redox control. The stable metabolites nitrate (NO3) and nitrite (NO2) may indicate real-time follicular function during IVF. Methods: [...] Read more.
Background: Nitric oxide (NO) is an important modulator of ovarian physiology, which contributes to angiogenesis, steroidogenesis, and redox control. The stable metabolites nitrate (NO3) and nitrite (NO2) may indicate real-time follicular function during IVF. Methods: In this prospective study, we included 89 women who underwent controlled ovarian stimulation. The Griess test was used to measure NO2-NO3 concentrations in follicular fluid collected on the day of oocyte retrieval. Non-parametric and correlation tests were used to investigate the associations between oocyte yield, maturity (MII), fertilization (2PN), embryo development, and hormone levels. Results: Higher NO2-NO3 levels were substantially associated with increased total oocyte count, MII oocytes (p = 0.014), and 2PN embryos (p = 0.029). This suggests a strong relationship between NO bioavailability and oocyte competence. NO2-NO3 levels showed a positive correlation with estradiol (p < 0.001) and progesterone (p < 0.001), suggesting a possible function in granulosa cell steroidogenesis. Conclusions: Follicular NO metabolites are candidate functional indicators for oocyte quality evaluation and intrafollicular steroidogenic activity. Their predictive value may improve customized IVF treatment, especially in individuals with complicated ovarian phenotypes such as PCOS or decreased ovarian reserve. Full article
(This article belongs to the Special Issue New Advances in Human Reproductive Biology)
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