Breast Cancer: Molecular and Translational Aspects on Carcinogenesis and Treatments
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 June 2026
Special Issue Editor
Interests: molecular biology of breast cancer; epithelial–mesenchymal transition (EMT); hippo pathway; integrin-linked kinase (ILK)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer treatment is increasingly guided by molecular profiling of individual tumors. Currently, breast cancer is classified into four molecular subtypes: luminal A, luminal B, HER-2 positive, and triple-negative breast cancer (TNBC). This classification plays an important role in guiding treatment decisions, both in the adjuvant and neoadjuvant setting. In recent years, advances in breast cancer oncology has led to the development and implementation of genetic profiling tools that help assess recurrence risk and predict the potential benefit of chemotherapy. However, significant challenges remain. Resistance to therapy, disease recurrence, and the lack of successful targeted therapies for TNBC highlight the urgent need for further research into the molecular pathobiology of breast cancer.
From a surgical perspective, some of the most promising opportunities lie in applying molecular tools to enhance cancer diagnosis and optimize treatment strategies. In this Special Issue, we welcome the submission of both original research and review articles focused on molecular and translational aspects of breast cancer carcinogenesis and treatments.
Dr. Ioanna Akrida
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer carcinogenesis
- triple-negative breast cancer (TNBC)
- HER2
- endocrine therapy
- neoadjuvant chemotherapy (NACT)
- immunotherapy
- tumor profiling molecular tests
- liquid biopsy circulating tumor cells (CTCs)
- circulating tumor DNA (ctDNA)
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