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Biomolecules, Volume 9, Issue 12

December 2019 - 141 articles

Cover Story: The coagulation Factor FXIIIA2B2 complex lies at a crucial junction between bleeding and thrombosis in the hemostatic order of the blood coagulation pathway. The absence of a biophysical/all atom structure for this complex limits the ability of coagulation scientists from designing putative inhibitors/drugs against this complex for related pathological states. It also limits the understanding of structural–functional aspects for this complex. To fill this void, we present in our current study the first all atom model of this complex built using integrative hybrid approaches that combine techniques of mass spectrometry, molecular modeling/docking, and atomic force microscopy. Furthermore, based on the structure and thermodynamic patterns, we present insights into the assembly and the activation induced disassembly of this complex. View this paper.
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Articles (141)

  • Review
  • Open Access
8 Citations
5,115 Views
26 Pages

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

  • Robert Ancuceanu,
  • Adriana Iuliana Anghel,
  • Camelia Ionescu,
  • Marilena Viorica Hovaneț,
  • Maria Cojocaru-Toma and
  • Mihaela Dinu

17 December 2019

It is currently recognized that an injudicious strategy about caries in the last decades has been not only focusing of research mostly in children, but also the narrow focusing on fluoride, because despite sufficient availability of fluoride in water...

  • Article
  • Open Access
29 Citations
3,756 Views
11 Pages

17 December 2019

The chemical and physical properties of extracellular rhamnolipid synthesized by a nonfluorescent Pseudomonas species soil isolate, identified as DYNA270, is described, along with characteristics of rhamnolipid production under varying growth conditi...

  • Article
  • Open Access
47 Citations
7,908 Views
17 Pages

17 December 2019

ACE2 is a monocarboxypeptidase which generates Angiotensin (1–7) from Angiotensin II (1–8). Attempts to target the kidney Renin Angiotensin System using native ACE2 to treat kidney disease are hampered by its large molecular size, 100 kDa, which prec...

  • Review
  • Open Access
90 Citations
11,348 Views
17 Pages

A Sight to Wheat Bran: High Value-Added Products

  • Agne Katileviciute,
  • Gediminas Plakys,
  • Aida Budreviciute,
  • Kamil Onder,
  • Samar Damiati and
  • Rimantas Kodzius

17 December 2019

Recently more consideration has been given to the use of renewable materials and agricultural residues. Wheat production is increasing yearly and correspondingly, the volume of by-products from the wheat process is increasing, as well. It is importan...

  • Review
  • Open Access
172 Citations
24,397 Views
21 Pages

Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health

  • Vidhu Gill,
  • Vijay Kumar,
  • Kritanjali Singh,
  • Ashok Kumar and
  • Jong-Joo Kim

17 December 2019

The Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo during the cooking or processing of foods under high-temperature conditions, such as baking, frying, or grilling. Glycation of proteins is a post-translati...

  • Article
  • Open Access
7 Citations
4,353 Views
15 Pages

Exploration of the Misfolding Mechanism of Transthyretin Monomer: Insights from Hybrid-Resolution Simulations and Markov State Model Analysis

  • Shuangyan Zhou,
  • Jie Cheng,
  • Ting Yang,
  • Mingyue Ma,
  • Wenying Zhang,
  • Shuai Yuan,
  • Glenn V. Lo and
  • Yusheng Dou

17 December 2019

Misfolding and aggregation of transthyretin (TTR) is widely known to be responsible for a progressive systemic disorder called amyloid transthyretin (ATTR) amyloidosis. Studies suggest that TTR aggregation is initiated by a rate-limiting dissociation...

  • Feature Paper
  • Article
  • Open Access
21 Citations
5,104 Views
13 Pages

Protective Effect of Panaxynol Isolated from Panax vietnamensis against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies

  • Dahae Lee,
  • Jaemin Lee,
  • Kim Long Vu-Huynh,
  • Thi Hong Van Le,
  • Thi Hong Tuoi Do,
  • Gwi Seo Hwang,
  • Jeong Hill Park,
  • Ki Sung Kang,
  • Minh Duc Nguyen and
  • Noriko Yamabe

17 December 2019

Polyacetylenic compounds isolated from Panax species are comprised of non-polar C17 compounds, exhibiting anti-inflammatory, antitumor, and antifungal activities. Panaxynol represents the major component of the essential oils of ginseng. We investiga...

  • Article
  • Open Access
12 Citations
4,382 Views
19 Pages

Preclinical Evaluation of the Antimicrobial-Immunomodulatory Dual Action of Xenohormetic Molecules against Haemophilus influenzae Respiratory Infection

  • Ariadna Fernández-Calvet,
  • Begoña Euba,
  • Lucía Caballero,
  • Roberto Díez-Martínez,
  • Margarita Menéndez,
  • Carlos Ortiz de Solórzano,
  • José Leiva,
  • Vicente Micol,
  • Enrique Barrajón-Catalán and
  • Junkal Garmendia

17 December 2019

Chronic obstructive pulmonary disease (COPD) is characterized by abnormal inflammation and impaired airway immunity, providing an opportunistic platform for nontypeable Haemophilus influenzae (NTHi) infection. In this context, therapies targeting not...

  • Article
  • Open Access
23 Citations
4,599 Views
15 Pages

N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats

  • Rade Vukovic,
  • Igor Kumburovic,
  • Jovana Joksimovic Jovic,
  • Nemanja Jovicic,
  • Jelena S. Katanic Stankovic,
  • Vladimir Mihailovic,
  • Milos Djuric,
  • Stefan Velickovic,
  • Aleksandra Arnaut and
  • Dragica Selakovic
  • + 1 author

17 December 2019

Since cisplatin therapy is usually accompanied with numerous toxicities, including neurotoxicity, that involve tissue oxidative damage, the aim of this study was to evaluate the possible protective effect of N-acetylcysteine (NAC) on the anxiogenic r...

  • Review
  • Open Access
128 Citations
13,769 Views
11 Pages

Hypertrophic Cardiomyopathy: An Overview of Genetics and Management

  • Polakit Teekakirikul,
  • Wenjuan Zhu,
  • Helen C. Huang and
  • Erik Fung

16 December 2019

Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac muscle disorder with a diverse natural history, characterized by unexplained left ventricular hypertrophy (LVH), with histopathological hallmarks including myocyte enlargement,...

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Biomolecules - ISSN 2218-273XCreative Common CC BY license