Advances in Cholinesterases

Dear Colleagues,

Cholinesterases (ChEs; acetylcholinesterase and butyrylcholinesterase) play an important role in human beings. Their inhibition is a life-threatening event causing cholinergic crisis and possibly death. At present, they are widely discussed since they are target of nerve agent poisoning (a family of chemical warfare agents). To restore their function, cholinesterase reactivators have been developed to counteract their action. Not only nerve agents but also organophosphorus or carbamate pesticides exert the same inhibitory effect on ChEs.

ChEs are also associated with Alzheimer’s disease, so they are a target of novel drugs against this disease. Most recently, ChEs have also been reported to be a target for insecticides. That is why there are so many modulators of ChEs developed in the past or under development all around the world.

The focus of this Special Issue of Biomolecules will be the most recent advances related to ChE modulators (inhibitors/reactivators) or ChEs themselves used as possible drugs. Also, ChEs as diagnostic tools can be presented in this Issue. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.

Prof. Kamil Kuca
Dr. Marek Bajda
Dr. Namrata Singh
Dr. Eugenie Nepovimova
Guest Editors

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