Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Table of Contents
Biomolecules, Volume 10, Issue 1 (January 2020) – 163 articles
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) In this paper, a combination of theoretical and experimental approaches towards a rational design [...] Read more. In this paper, a combination of theoretical and experimental approaches towards a rational design of amyloid-forming peptides comprising natural beta-sheet cores was used. The peptides were designed to contain positively charged and aromatic residues exposed at key positions in order to promote both DNA condensation and cell internalization. These designer peptide fibrils can efficiently enter mammalian cells while carrying packaged luciferase encoding plasmid DNA and act as a protein expression enhancer. They also exhibited strong antimicrobial activity against E. coli bacteria. Such designer amyloid materials could constitute a stepping stone for using amyloids as novel biomaterial scaffolds which combine cell penetration and gene transfer along with antibacterial properties. View this paper.