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Special Issue "Genetics of Cardiovascular Disorders"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (1 November 2019).
The Human Genome Project, launched in 1990, with the aim to sequence all 3 billion base pairs of nucleotides, achieved completion in 2003 ahead of schedule. Surprisingly, only ~20,000 genes code for the entire human proteins and RNAs led to realization and revision of the one gene-one protein dogma. Following these landmark findings, the 1000 Genomes Project (to catalogue sequence variants in the human genome) and the Cancer Genome Atlas (to characterize mutations leading to cancer) were launched. These efforts are beginning to bear fruit in ushering in an era of personalized medicine best exemplified in cancer therapeutics.
However, the field of cardiovascular medicine is not far behind. Genome-wide association studies have identified now a total of 26 genetic loci associated with atrial fibrillation. Studies associating the risk of atherosclerosis with genetic loci in high-risk populations for coronary artery disease are emerging. Genome-wide association studies have also led to a burst of discovery in novel genetic susceptibility loci for hypertension. Perhaps the most significant advances have been in predicting the genetic basis of risk in cardiomyopathies like dilated cardiomyopathy and hypertrophic obstructive cardiomyopathy. Predicting the risk of sudden cardiac death on a genetic basis would significantly help the clinician in tailoring therapy according to risk. The aim of this Issue is to bring to the reader recent developments in understanding the genetic basis of myriad cardiovascular disorders ranging from congenital heart disease to atrial fibrillation to valvular heart disease and cardiomyopathies.
Dr. Maliha Zahid
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- congenital heart disease
- atrial fibrillation
- hypertrophic obstructive cardiomyopathy
- dilated cardiomyopathy
- valvular heart disease
- diabetes mellitus
- aortic aneurysm