Special Issue "Protein Folding and Quality Control Mechanisms - In Memory of Prof. Oleg B. Ptitsyn (1929-1999)"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (30 November 2019).
Interests: protein physics; theoretical investigations of protein folding; molecular physics; molecular biology; biochemistry; biocomputing; protein engineerings; protein structure; protein folding; phase transitions; antifreeze proteins; amyloids
Special Issues, Collections and Topics in MDPI journals
The mysterious ability of protein chains, initially disordered, to spontaneously form their unique 3D structures has long served as an exciting puzzle for molecular biologists, physicists, and chemists. Now, when this puzzle is solved in its basics for in vitro folding of small globular proteins, and when it has been demonstrated that in vivo folding of such proteins is similar to their in vitro folding (that is, they remain unstructured during biosynthesis and get their native fold only when the entire sequence is available), the main interest is, in my opinion, shifted to folding, unfolding, and misfolding of larger globular and to non-globular (especially membrane) proteins. In particular: how long should the “unfinished” protein chain emerging at a ribosome be to form a definite 3D structure? Is this first-formed structure a native-like one? Are there thermodynamically stable but kinetically unattainable folds of protein chains? Are these rare exceptions or the main body of the protein fold space? Do chaperones actively form protein structures, and if so, how? Or do they only “passively” eliminate “unwanted” association of protein chains? What is the difference between chaperones dealing with water-soluble and membrane proteins? How does the protein structure control in vivo look like? Further, an overview of achievements of protein engineering and design, especially on intriguing “chameleon” proteins, is highly desirable. This Special Issue will focus on the various aspects of protein folding, misfolding, and unfolding.
We look forward to reading your contributions,
Prof. Alexei Finkelstein
Manuscript Submission Information
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- Protein folding
- protein unfolding
- protein misfolding
- co-translational folding
- protein structure
- protein structure control
- structural transformations
- protein physics
- protein engineering