Oxidative Damage on Biomolecules and Antioxidants
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (16 November 2019) | Viewed by 29383
Special Issue Editors
Special Issue Information
Dear Colleagues,
There is a growing experimental interest to understand oxidative stress-related diseases’ mechanisms and novel therapeutic approaches. Oxidative stress is induced by an impaired redox balance, due to the excessive production of free radical-induced reactive oxygen species (ROS) or the dysfunction of the antioxidant status. ROS are strong oxidants capable of damaging lipids, proteins, and DNA. The oxidative products issuing from each biomolecule are complex and variable. The general mechanisms of oxidative damage to biomolecules, which results in the dysfunction of the biomolecules and interference with the signaling pathways, leading to oxidative stress-induced diseases. Due to the deleterious effects of oxidative stress, cells developed different mechanisms called antioxidants to cope with the challenge. Antioxidant molecules, both enzymatic and non-enzymatic, are preventative or repair-systems against ROS, they may be endogenous and exogenous or primary and secondary, natural or synthetic. Although efficient, the antioxidant enzymes and compounds do not prevent the oxidative damage completely.
Oxidative stress is well known to be involved in the pathogenesis of various diseases, including neurodegenerative diseases, inflammation, aging, atherosclerosis, hypertension, diabetes mellitus, ischemic diseases, and cancer. The biomarkers that can be used to assess oxidative stress have been attracting interest because the accurate assessment of such stress is necessary for investigation of various pathological conditions, as well as to evaluate the efficacy of drugs. With this Special Issue, the most recent experimental and therapeutic information will be discussed and gathered in order to understand the pathophysiological mechanisms related to oxidative stress-mediated diseases, which will serve as a basis for future studies.
Prof. Dr. Hafize Uzun
Dr. Karolin Yanar
Prof. Dr. Pınar Atukeren
Guest Editors
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Keywords
- Oxidative stress
- Reactive oxygen species
- Free radicals
- Redox balance
- Antioxidant
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