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Metabolites, Volume 10, Issue 8

2020 August - 36 articles

Cover Story: Metabolomics approaches are useful tools for the simultaneous detection of endogenous metabolites affected by drug use. We performed comparative metabolic profiling of three psychoactive stimulant drugs—MDMA, amphetamine, and the new psychoactive substance (NPS) mephedrone—using liquid chromatography–high-resolution mass spectrometry from plasma samples in controlled administration studies of humans. Various metabolites were identified as increased or decreased based on drug intake, and mainly belonged to energy metabolism, steroid biosynthesis, or amino acids. Linoleic acid and pregnenolone sulfate changed similarly in response to intake of all drugs. Overall, the profile of mephedrone was more similar to that of amphetamine than that of MDMA. These data can provide the basis for further targeted metabolome studies on pharmacological actions and the search for biomarkers of drug use. View this paper
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Articles (36)

  • Review
  • Open Access
207 Citations
11,615 Views
30 Pages

18 August 2020

Arbuscular mycorrhizal fungi (AMF) is among the most ubiquitous plant mutualists that enhance plant growth and yield by facilitating the uptake of phosphorus and water. The countless interactions that occur in the rhizosphere between plants and its A...

  • Article
  • Open Access
7 Citations
3,693 Views
14 Pages

L-Ascorbate Biosynthesis Involves Carbon Skeleton Rearrangement in the Nematode Caenorhabditis elegans

  • Yukinori Yabuta,
  • Ryuta Nagata,
  • Yuka Aoki,
  • Ayumi Kariya,
  • Kousuke Wada,
  • Ayako Yanagimoto,
  • Hiroka Hara,
  • Tomohiro Bito,
  • Naho Okamoto and
  • Fumio Watanabe
  • + 2 authors

17 August 2020

Ascorbate (AsA) is required as a cofactor and is widely distributed in plants and animals. Recently, it has been suggested that the nematode Caenorhabditis elegans also synthesizes AsA. However, its biosynthetic pathway is still unknown. To further u...

  • Review
  • Open Access
13 Citations
3,740 Views
15 Pages

14 August 2020

While immunotherapies for diverse types of cancer are effective in many cases, relapse is still a lingering problem. Like tumor cells, activated immune cells have an anabolic metabolic profile, relying on glycolysis and the increased uptake and synth...

  • Article
  • Open Access
5 Citations
3,419 Views
16 Pages

Metabolomics Comparison of Hanwoo (Bos taurus coreanae) Biofluids Using Proton Nuclear Magnetic Resonance Spectroscopy

  • Jun Sik Eom,
  • Shin Ja Lee,
  • Hyun Sang Kim,
  • You Young Choi,
  • Sang Ho Kim,
  • Yoo Gyung Lee and
  • Sung Sill Lee

14 August 2020

The aim of this study was to identify the metabolomic profiles of rumen fluid, serum, and urine from Hanwoo (Bos taurus coreanae), using proton nuclear magnetic resonance (1H-NMR) spectroscopy. In all, 189, 110, and 188 metabolites were identified in...

  • Article
  • Open Access
10 Citations
3,395 Views
19 Pages

Associations of BMI and Body Fat with Urine Metabolome in Adolescents Are Sex-Specific: A Cross-Sectional Study

  • Christian Brachem,
  • Julia Langenau,
  • Leonie Weinhold,
  • Matthias Schmid,
  • Ute Nöthlings and
  • Kolade Oluwagbemigun

13 August 2020

Epidemiologic studies examining the relationship between body composition and the urine metabolome may improve our understanding of the role of metabolic dysregulation in body composition-related health conditions. Previous studies, mostly in adult p...

  • Article
  • Open Access
25 Citations
4,534 Views
14 Pages

Antibiotics Effects on the Fecal Metabolome in Preterm Infants

  • Laura Patton,
  • Nan Li,
  • Timothy J. Garrett,
  • J. Lauren Ruoss,
  • Jordan T. Russell,
  • Diomel de la Cruz,
  • Catalina Bazacliu,
  • Richard A. Polin,
  • Eric W. Triplett and
  • Josef Neu

13 August 2020

Within a randomized prospective pilot study of preterm infants born at less than 33 weeks’ gestation, weekly fecal samples from 19 infants were collected and metabolomic analysis was performed. The objective was to evaluate for differences in f...

  • Article
  • Open Access
17 Citations
3,789 Views
13 Pages

Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin

  • Jiří Vrba,
  • Barbora Papoušková,
  • Pavel Kosina,
  • Kateřina Lněničková,
  • Kateřina Valentová and
  • Jitka Ulrichová

12 August 2020

Natural phenolic compounds are known to be metabolized by phase II metabolic reactions. In this study, we examined the in vitro sulfation of the main constituents of silymarin, an herbal remedy produced from the fruits of the milk thistle. The study...

  • Article
  • Open Access
6 Citations
6,474 Views
24 Pages

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling

  • Joselyn N. Allen,
  • Adwitia Dey,
  • Jingwei Cai,
  • Jingtao Zhang,
  • Yuan Tian,
  • Mary Kennett,
  • Yanling Ma,
  • T. Jake Liang,
  • Andrew D. Patterson and
  • Pamela A. Hankey-Giblin

11 August 2020

Non-alcoholic steatohepatitis (NASH) represents the progressive sub-disease of non-alcoholic fatty liver disease that causes chronic liver injury initiated and sustained by steatosis and necroinflammation. The Ron receptor is a tyrosine kinase of the...

  • Article
  • Open Access
13 Citations
3,347 Views
16 Pages

VenoMS—A Website for the Low Molecular Mass Compounds in Spider Venoms

  • Yvonne M. Forster,
  • Silvan Reusser,
  • Florian Forster,
  • Stefan Bienz and
  • Laurent Bigler

11 August 2020

Spider venoms are highly complex mixtures. Numerous spider venom metabolites are uniquely found in spider venoms and are of interest concerning their potential use in pharmacology, agriculture, and cosmetics. A nontargeted ultra-high performance high...

  • Review
  • Open Access
27 Citations
4,635 Views
28 Pages

Metabolomics in Radiation Biodosimetry: Current Approaches and Advances

  • Merriline M. Satyamitra,
  • David R. Cassatt,
  • Brynn A. Hollingsworth,
  • Paul W. Price,
  • Carmen I. Rios,
  • Lanyn P. Taliaferro,
  • Thomas A. Winters and
  • Andrea L. DiCarlo

11 August 2020

Triage and medical intervention strategies for unanticipated exposure during a radiation incident benefit from the early, rapid and accurate assessment of dose level. Radiation exposure results in complex and persistent molecular and cellular respons...

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Metabolites - ISSN 2218-1989