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Metabolites, Volume 10, Issue 12

December 2020 - 42 articles

Cover Story: Filigree is a Java-based tool that implements our previously published Differential Network Enrichment Analysis (DNEA) algorithm. Filigree can build robust data-driven partial correlation networks from high-dimensional metabolomics and lipidomics data. If the number of metabolites far exceeds the number of samples, Filigree can perform feature aggregation to reduce data dimensionality. Our methodology can also handle imbalanced experimental designs. Filigree provides an alternative to traditional knowledge-based enrichment testing methods. We demonstrate the utility of Filigree by applying it to previously published studies analyzing the metabolome in the context of metabolic disorders. View this paper
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Articles (42)

  • Article
  • Open Access
73 Citations
6,734 Views
18 Pages

Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma

  • Giuseppe Lucarelli,
  • Matteo Ferro,
  • Davide Loizzo,
  • Cristina Bianchi,
  • Daniela Terracciano,
  • Francesco Cantiello,
  • Lauren N. Bell,
  • Stefano Battaglia,
  • Camillo Porta and
  • Angela Gernone
  • + 7 authors

13 December 2020

Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, in this study we delineated a lipidomic profile of human ccRCC and integrated it with transcriptomic data to conn...

  • Article
  • Open Access
14 Citations
3,956 Views
29 Pages

Comparative Analysis of Milk Triglycerides Profile between Jaffarabadi Buffalo and Holstein Friesian Cow

  • Aparna Verma,
  • Ningombam Sanjib Meitei,
  • Prakash U. Gajbhiye,
  • Mark J. Raftery and
  • Kiran Ambatipudi

11 December 2020

Milk lipids are known for a variety of biological functions, however; little is known about compositional variation across breeds, especially for Jaffarabadi buffalo, an indigenous Indian breed. Systematic profiling of extracted milk lipids was perfo...

  • Article
  • Open Access
21 Citations
4,549 Views
9 Pages

The Ketogenic Diet Increases In Vivo Glutathione Levels in Patients with Epilepsy

  • Antonio Napolitano,
  • Daniela Longo,
  • Martina Lucignani,
  • Luca Pasquini,
  • Maria Camilla Rossi-Espagnet,
  • Giulia Lucignani,
  • Arianna Maiorana,
  • Domenica Elia,
  • Paola De Liso and
  • Carlo Dionisi-Vici
  • + 1 author

10 December 2020

The Ketogenic Diet (KD) is a high-fat, low-carbohydrate diet that has been utilized as the first line treatment for contrasting intractable epilepsy. It is responsible for the presence of ketone bodies in blood, whose neuroprotective effect has been...

  • Review
  • Open Access
204 Citations
18,062 Views
26 Pages

Biostimulants for Plant Growth and Mitigation of Abiotic Stresses: A Metabolomics Perspective

  • Lerato Nephali,
  • Lizelle A. Piater,
  • Ian A. Dubery,
  • Veronica Patterson,
  • Johan Huyser,
  • Karl Burgess and
  • Fidele Tugizimana

10 December 2020

Adverse environmental conditions due to climate change, combined with declining soil fertility, threaten food security. Modern agriculture is facing a pressing situation where novel strategies must be developed for sustainable food production and sec...

  • Article
  • Open Access
24 Citations
3,715 Views
13 Pages

Using an Untargeted Metabolomics Approach to Identify Salivary Metabolites in Women with Breast Cancer

  • Daniele Xavier Assad,
  • Ana Carolina Acevedo,
  • Elisa Cançado Porto Mascarenhas,
  • Ana Gabriela Costa Normando,
  • Valérie Pichon,
  • Helene Chardin,
  • Eliete Neves Silva Guerra and
  • Audrey Combes

10 December 2020

Metabolic alterations are a hallmark of the malignant transformation in cancer cells, which is characterized by multiple changes in metabolic pathways that are linked to macromolecule synthesis. This study aimed to explore whether salivary metabolite...

  • Article
  • Open Access
5 Citations
3,325 Views
11 Pages

9 December 2020

In both humans and animals, meat not only constitutes one of the sources of protein, but also includes various water-soluble bioactive substances such as imidazole peptides (carnosine and anserine) and taurine. Previous studies demonstrated that diet...

  • Article
  • Open Access
19 Citations
8,272 Views
18 Pages

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics

  • Holden C. Williams,
  • Margaret A. Piron,
  • Grant K. Nation,
  • Adeline E. Walsh,
  • Lyndsay E. A. Young,
  • Ramon C. Sun and
  • Lance A. Johnson

8 December 2020

Stable isotope-resolved metabolomics (SIRM) is a powerful tool for understanding disease. Advances in SIRM techniques have improved isotopic delivery and expanded the workflow from exclusively in vitro applications to in vivo methodologies to study s...

  • Article
  • Open Access
40 Citations
23,605 Views
20 Pages

Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids

  • Dimitris Tsoukalas,
  • Vassileios Fragoulakis,
  • Evangelos Papakonstantinou,
  • Maria Antonaki,
  • Athanassios Vozikis,
  • Aristidis Tsatsakis,
  • Ana Maria Buga,
  • Mihaela Mitroi and
  • Daniela Calina

8 December 2020

Autoimmune diseases (ADs) are chronic disorders characterized by the loss of self-tolerance, and although being heterogeneous, they share common pathogenic mechanisms. Self-antigens and inflammation markers are established diagnostic tools; however,...

  • Article
  • Open Access
42 Citations
7,910 Views
18 Pages

Caulerpa lentillifera (Sea Grapes) Improves Cardiovascular and Metabolic Health of Rats with Diet-Induced Metabolic Syndrome

  • Ryan du Preez,
  • Marwan E. Majzoub,
  • Torsten Thomas,
  • Sunil K. Panchal and
  • Lindsay Brown

7 December 2020

Caulerpa lentillifera (sea grapes) is widely consumed in South-East Asia as a low-energy food with high contents of vitamins and minerals. This study investigated dried sea grapes containing 16.6% insoluble fibre commercially produced in Vietnam as a...

  • Article
  • Open Access
10 Citations
4,535 Views
15 Pages

Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women

  • Chung-Ho E. Lau,
  • Victoria Taylor-Bateman,
  • Panagiotis A. Vorkas,
  • Gonçalo Graça,
  • Thanh-Huyen T. Vu,
  • Lifang Hou,
  • Elena Chekmeneva,
  • Timothy M. D. Ebbels,
  • Queenie Chan and
  • Linda Van Horn
  • + 1 author

4 December 2020

Background: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling i...

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Metabolites - ISSN 2218-1989