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Article

Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women

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Section of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK
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Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK
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William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
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Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK
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Institute of Applied Biosciences, Centre for Research and Technology Hellas, 57001 Thessaloniki, Greece
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Section of Bioinformatics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK
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Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
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National Phenome Centre and Section of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, IRDB Building, London W12 0NN, UK
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MRC Centre for Environment and Health, Imperial College London, London W2 1PG, UK
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Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia
*
Authors to whom correspondence should be addressed.
Joint Senior Authors.
Metabolites 2020, 10(12), 498; https://doi.org/10.3390/metabo10120498
Received: 2 November 2020 / Revised: 30 November 2020 / Accepted: 1 December 2020 / Published: 4 December 2020
(This article belongs to the Special Issue Nutrients and Metabolic Syndrome)
Background: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy could potentially be applied to elucidate the molecular basis of the adverse effects of gestational weight gain (GWG) and postpartum weight loss (WL) on future risks for cardiovascular disease (CVD) and other chronic diseases. Methods: Biofluid samples were collected from 114 ethnically diverse pregnant women with body mass index (BMI) between 25 and 40 kg/m2 from Chicago (US), as part of a randomized lifestyle intervention trial (Maternal Offspring Metabolics: Family Intervention Trial; NCT01631747). At 15 weeks, 35 weeks of gestation, and at 1 year postpartum, the blood plasma lipidome and metabolic profile of urine samples were analyzed by liquid chromatography mass spectrometry (LC-MS) and 1H nuclear magnetic resonance spectroscopy (1H NMR) respectively. Results: Urinary 4-deoxyerythronic acid and 4-deoxythreonic acid were found to be positively correlated to BMI. Seventeen plasma lipids were found to be associated with GWG and 16 lipids were found to be associated with WL, which included phosphatidylinositols (PI), phosphatidylcholines (PC), lysophospholipids (lyso-), sphingomyelins (SM) and ether phosphatidylcholine (PC-O). Three phospholipids found to be positively associated with GWG all contained palmitate side-chains, and amongst the 14 lipids that were negatively associated with GWG, seven were PC-O. Six of eight lipids found to be negatively associated with WL contained an 18:2 fatty acid side-chain. Conclusions: Maternal obesity was associated with characteristic urine and plasma metabolic phenotypes, and phospholipid profile was found to be associated with both GWG and postpartum WL in metabolically healthy pregnant women with overweight/obesity. Postpartum WL may be linked to the reduction in the intake of linoleic acid/conjugated linoleic acid food sources in our study population. View Full-Text
Keywords: metabolic phenotyping; metabolomics; blood lipids; LC-MS; NMR; gestational weight gain; lifestyle intervention metabolic phenotyping; metabolomics; blood lipids; LC-MS; NMR; gestational weight gain; lifestyle intervention
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MDPI and ACS Style

Lau, C.-H.E.; Taylor-Bateman, V.; Vorkas, P.A.; Graça, G.; Vu, T.-H.T.; Hou, L.; Chekmeneva, E.; Ebbels, T.M.D.; Chan, Q.; Van Horn, L.; Holmes, E. Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women. Metabolites 2020, 10, 498. https://doi.org/10.3390/metabo10120498

AMA Style

Lau C-HE, Taylor-Bateman V, Vorkas PA, Graça G, Vu T-HT, Hou L, Chekmeneva E, Ebbels TMD, Chan Q, Van Horn L, Holmes E. Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women. Metabolites. 2020; 10(12):498. https://doi.org/10.3390/metabo10120498

Chicago/Turabian Style

Lau, Chung-Ho E., Victoria Taylor-Bateman, Panagiotis A. Vorkas, Gonçalo Graça, Thanh-Huyen T. Vu, Lifang Hou, Elena Chekmeneva, Timothy M. D. Ebbels, Queenie Chan, Linda Van Horn, and Elaine Holmes. 2020. "Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women" Metabolites 10, no. 12: 498. https://doi.org/10.3390/metabo10120498

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