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Open AccessArticle

Caulerpa lentillifera (Sea Grapes) Improves Cardiovascular and Metabolic Health of Rats with Diet-Induced Metabolic Syndrome

1
Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia
2
Centre for Marine Science and Innovation, University of New South Wales, Sydney, NSW 2052, Australia
3
School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia
4
School of Health and Wellbeing, University of Southern Queensland, Ipswich, QLD 4305, Australia
*
Author to whom correspondence should be addressed.
Current address: School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD 4701, Australia.
Current address: School of Science, Western Sydney University, Richmond, NSW 2753, Australia.
Metabolites 2020, 10(12), 500; https://doi.org/10.3390/metabo10120500
Received: 12 October 2020 / Revised: 23 November 2020 / Accepted: 3 December 2020 / Published: 7 December 2020
(This article belongs to the Special Issue Seaweeds Metabolites Volume 2)
Caulerpa lentillifera (sea grapes) is widely consumed in South-East Asia as a low-energy food with high contents of vitamins and minerals. This study investigated dried sea grapes containing 16.6% insoluble fibre commercially produced in Vietnam as an intervention. We hypothesised that insoluble fibre is the primary metabolite that will reverse diet-induced metabolic syndrome. Male Wistar rats (n = 48) were randomly allocated to four groups in a 16 week protocol. Two groups were fed either corn starch (C) or high-carbohydrate, high-fat (H) diets for the full 16 weeks. The other two groups received C and H diets for eight weeks and then received C. lentillifera added to these diets for the final eight weeks (CCL and HCL, respectively). High-carbohydrate, high-fat diet-fed rats developed obesity, hypertension, dyslipidaemia, fatty liver disease and increased left ventricular collagen deposition. C. lentillifera supplementation in HCL rats decreased body weight, systolic blood pressure, plasma concentrations of total cholesterol and non-esterified fatty acids, inflammatory cells in heart and liver, and visceral adiposity. The Firmicutes to Bacteroidetes ratio decreased in the gut microbiota of HCL rats. Therefore, C. lentillifera attenuated cardiovascular and metabolic symptoms of metabolic syndrome in rats, possibly by preventing infiltration of inflammatory cells together with modulating gut microbiota. View Full-Text
Keywords: Caulerpa lentillifera; sea grapes; green seaweed; gut microbiota; metabolic syndrome Caulerpa lentillifera; sea grapes; green seaweed; gut microbiota; metabolic syndrome
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MDPI and ACS Style

du Preez, R.; Majzoub, M.E.; Thomas, T.; Panchal, S.K.; Brown, L. Caulerpa lentillifera (Sea Grapes) Improves Cardiovascular and Metabolic Health of Rats with Diet-Induced Metabolic Syndrome. Metabolites 2020, 10, 500. https://doi.org/10.3390/metabo10120500

AMA Style

du Preez R, Majzoub ME, Thomas T, Panchal SK, Brown L. Caulerpa lentillifera (Sea Grapes) Improves Cardiovascular and Metabolic Health of Rats with Diet-Induced Metabolic Syndrome. Metabolites. 2020; 10(12):500. https://doi.org/10.3390/metabo10120500

Chicago/Turabian Style

du Preez, Ryan; Majzoub, Marwan E.; Thomas, Torsten; Panchal, Sunil K.; Brown, Lindsay. 2020. "Caulerpa lentillifera (Sea Grapes) Improves Cardiovascular and Metabolic Health of Rats with Diet-Induced Metabolic Syndrome" Metabolites 10, no. 12: 500. https://doi.org/10.3390/metabo10120500

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