Metabolomics of Fatty Acyl Esters of Hydroxy Fatty Acids: Three Diverse Lipid Families

Dear Colleagues,

Fatty acyl esters of hydroxy fatty acids (FAHFA) encompass three different lipid families which have incorrectly been classified as wax esters. These families include i) branched-chain FAHFA, involved in regulation of glucose metabolism, with acylation of an internal branched-chain hydroxy-palmitic or -stearic acid; ii) ω-FAHFA, biosurfactants in a number of biofluids, with acylation of the ω-hydroxyl group of a very-long-chain fatty acid (these lipids have also been designated as o-acyl hydroxy fatty acids; OAHFA); and iii) ornithine-FAHFA, bacterial lipids, with acylation of short-chain 3-hydroxy fatty acids and addition of ornithine to the free carboxy group of the hydroxy fatty acid. The differences in biosynthetic pathways and cellular functions of these lipid families will be reviewed and compared to wax esters which are formed by acylation of a fatty alcohol. Analytical issues will also be addressed.

The Special Issue is open for submission now. Some extension may be granted if you kindly let me know in advance. Accepted papers will be published rapidly and will be listed together on the Special Issue website.

Prof. Dr. Paul Wood
Guest Editor

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