Metabolites, Volume 10, Issue 11 (November 2020) – 54 articles
Cover Story (view full-size image): Omega-3 treatment may lower cardiovascular risk, but its effects on the circulating lipidome and relation to cardiovascular risk biomarkers are unclear. We hypothesized that omega-3 treatment is associated with favorable changes in downstream fatty acids, oxylipins, bioactive lipids, and clinical lipid and inflammatory biomarkers. We examined these associations in the VITAL200, a nested substudy of 200 subjects randomly selected from VITamin D and OmegA-3 TriaL (VITAL). Omega-3 treatment results in major changes in bioactive lipidome which in turn has a mostly inverse association with one-year changes in inflammatory biomarkers and heterogeneous associations with changes in standard lipid biomarkers, including plasma triglycerides. Vew this paper.
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