Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
3.5
Journals
Biology
Special Issues
Pathophysiology of Chronic Inflammatory Diseases
share announcement

Pathophysiology of Chronic Inflammatory Diseases

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 1 December 2025 | Viewed by 2091

Special Issue Editor

Dr. Vincent Yuan

E-Mail Website
Guest Editor
Department of Otolaryngology, University of Pittsburgh Medical Center, 600 Grant St, Pittsburgh, PA 15219, USA
Interests: chronic inflammatory diseases; immune-mediated hearing disorders; macrophage and T cell biology; inflammasome activation; biomarkers; therapeutic targets
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic inflammatory diseases represent a significant global health challenge, affecting millions worldwide. These conditions, including autoimmune disorders, metabolic syndromes, and persistent infections, are characterized by sustained inflammation leading to tissue damage and organ dysfunction. Despite advances in understanding their mechanisms, the complexity of these diseases calls for further investigation to uncover new therapeutic avenues.

This Special Issue aims to explore the molecular, cellular, and systemic processes underlying chronic inflammation, offering insights into pathogenesis, diagnosis, and treatment strategies. We invite contributions addressing key areas such as immune cell dysregulation, cytokine signaling, and inflammasome activation, as well as the role of genetic, epigenetic, and environmental factors. Research on metabolic disturbances, oxidative stress, and their links to chronic inflammation is particularly welcome.

In this Special Issue, original research articles and reviews are encouraged. Topics may include (but are not limited to):

  • Mechanisms of immune cell activation and dysregulation;
  • Genetic and epigenetic factors in chronic inflammation;
  • Biomarkers for diagnosis and disease monitoring.

We look forward to your valuable contributions.

Dr. Vincent Yuan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic inflammation
  • autoimmune diseases
  • cytokines
  • inflammasome
  • metabolic dysfunction
  • oxidative stress
  • biomarkers
  • epigenetics
  • personalized medicine
  • therapeutic targets

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

23 pages, 3615 KiB  
Article
Mechanisms of Aletris spicata (Thunb.) Franch. Extract in Asthma Therapy: Oxidative Stress, Inflammation, and Gut Microbiota
by Jing Yang, Zhiyong Chen, Yue Zhu, Teng Chen, Ying Zhou and Zuhua Wang
Biology 2025, 14(6), 731; https://doi.org/10.3390/biology14060731 - 19 Jun 2025
Viewed by 359
Abstract
Aletris spicata (Thunb.) Franch. (AS), a traditional edible and medicinal plant for treating asthma, was investigated for its therapeutic mechanisms. Liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) analysis identified 33 compounds in AS. In ovalbumin (OVA)-induced asthmatic mice, AS significantly reduced inflammatory cells (neutrophils, [...] Read more.
Aletris spicata (Thunb.) Franch. (AS), a traditional edible and medicinal plant for treating asthma, was investigated for its therapeutic mechanisms. Liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) analysis identified 33 compounds in AS. In ovalbumin (OVA)-induced asthmatic mice, AS significantly reduced inflammatory cells (neutrophils, lymphocytes, eosinophils) in bronchoalveolar lavage fluid (BALF) and decreased IL-4, IL-5, IL-13, TNF-α, and serum IgE while increasing IFN-γ. AS alleviated lung and intestinal inflammation, reduced ROS and MDA levels, and enhanced SOD activity. Immunohistochemistry and Western blot revealed AS upregulated Nrf2/HO-1 expression and inhibited NF-κB p65 nuclear translocation. Gut microbiota studies demonstrated AS restored intestinal flora homeostasis by modulating the richness, diversity, and composition. Spearman correlation analysis identified significant relationships between oxidative stress markers, inflammatory cytokines, and specific gut bacteria. These findings indicate that AS mitigates asthma through antioxidant effects (Nrf2/HO-1 pathway), anti-inflammatory actions (NF-κB pathway), and gut microbiota modulation. The study provides a scientific basis for developing AS as a natural anti-asthma treatment or functional food. The multi-target mechanism involving oxidative stress, inflammation, and gut flora highlights AS’s comprehensive therapeutic potential for asthma management. Full article
(This article belongs to the Special Issue Pathophysiology of Chronic Inflammatory Diseases)
►▼ Show Figures

Figure 1

14 pages, 7815 KiB  
Communication
Anti-Inflammatory Mechanism Prediction of Sinomenine Based on Network Pharmacology and Its Biological Activity Verification
by Da Song, Afsar Khan, Ming-Hong Dong, Chuan-Wen Lei, Ting-Ting Feng, Ying Zhou and Xin Wei
Biology 2025, 14(5), 543; https://doi.org/10.3390/biology14050543 - 13 May 2025
Viewed by 428
Abstract
Inflammation is a widespread physiological response that occurs when the body is stimulated by pathogens or endogenous signals [...] Full article
(This article belongs to the Special Issue Pathophysiology of Chronic Inflammatory Diseases)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

29 pages, 3987 KiB  
Review
Tryptophan-2,3-Dioxygenase as a Therapeutic Target in Digestive System Diseases
by Zhengsen Wang, Xianxian Xie, Yu Xue and Yixuan Chen
Biology 2025, 14(3), 295; https://doi.org/10.3390/biology14030295 - 15 Mar 2025
Viewed by 1029
Abstract
Tryptophan (Trp) is an essential amino acid that must be acquired exclusively through dietary intake. The metabolism of tryptophan plays a critical role in maintaining immune homeostasis and tolerance, as well as in preventing excessive inflammatory responses. Tryptophan-2,3-dioxygenase (TDO2) is a tetrameric heme [...] Read more.
Tryptophan (Trp) is an essential amino acid that must be acquired exclusively through dietary intake. The metabolism of tryptophan plays a critical role in maintaining immune homeostasis and tolerance, as well as in preventing excessive inflammatory responses. Tryptophan-2,3-dioxygenase (TDO2) is a tetrameric heme protein and serves as one of the pivotal rate-limiting enzymes in the first step of tryptophan metabolism. Dysregulation of TDO2 expression has been observed in various digestive system diseases, encompassing those related to the oral cavity, esophagus, liver, stomach, pancreas, and colon and rectum. Digestive system diseases are the most common clinical diseases, with complex clinical manifestations and interrelated symptoms, and have become a research hotspot in the field of medicine. Studies have demonstrated that aberrant TDO2 expression is closely associated with various clinical manifestations and disease outcomes in patients with digestive system disorders. Consequently, TDO2 has garnered increasing recognition as a promising therapeutic target for digestive system diseases in recent years, attracting growing attention. This article provides a brief overview of the role of TDO2 in the tryptophan pathway, emphasizing its significant involvement in diseases of the digestive system. Strategies targeting TDO2 through specific inhibitors suggest considerable promise in enhancing therapeutic outcomes for digestive diseases. Thus, this review concludes by discussing recent advancements in the development of TDO2 inhibitors. We believe that targeted inhibition of TDO2 combined with immunotherapy, the screening of a large number of natural products, and the assistance of artificial intelligence in drug design will be important directions for developing more effective TDO2 inhibitors and improving treatment outcomes in the future. Full article
(This article belongs to the Special Issue Pathophysiology of Chronic Inflammatory Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop