Redox Signaling and Oxidative Stress in Health and Disease

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 876

Special Issue Editors

Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si 56216, Jeonbuk, Republic of Korea
Interests: advanced bioconvergence; digital biotechnology; primatology; cancer biology; cancer stem cells; neurodegenerative diseases; therapeutic approaches; bioplasma
College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China
Interests: fibrosis; cancer biology; stem cells; stress response; neuroscience; drug screen; cell signaling pathways; plasma medicine

Special Issue Information

Dear Colleagues,

This Special Issue addresses the impact of redox signaling and oxidative stress on health and disease. Redox signaling is a crucial mechanism for maintaining physiological balance and regulating various cellular functions, while oxidative stress arises from the imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system, closely linked to disease development. This topic plays a significant role in advanced bioconvergence, digital biotechnology, aging, cancer, cardiovascular diseases, metabolic disorders, and neurodegenerative diseases. This Special Issue will highlight the latest research on the roles of redox signaling and oxidative stress in health and various diseases, as well as new therapeutic approaches related to these processes. Researchers are invited to present their findings, ranging from basic research to clinical applications, to advance the field of redox biology and explore the potential for disease prevention and treatment.

We look forward to your interest and contributions.

Dr. Taeho Kwon
Dr. Hu-Nan Sun
Guest Editors

Manuscript Submission Information

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Keywords

  • redox signaling
  • oxidative stress
  • antioxidant defense
  • cellular regulation
  • aging
  • cancer
  • cardiovascular diseases
  • neurodegenerative diseases
  • therapeutic approaches
  • digital biotechnology

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Published Papers (1 paper)

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Review

19 pages, 1223 KiB  
Review
Effect of Exercise on Regulating miRNA Expression in Brain Health and Diseases
by Jian Zhang, Fengmei Gu and Anand Thirupathi
Biology 2025, 14(6), 729; https://doi.org/10.3390/biology14060729 - 19 Jun 2025
Viewed by 406
Abstract
Physical exercise induces epigenetic modifications that significantly influence the expression of a set of small non-coding RNAs known as miRNAs. These changes can enhance exercise performance and impact the neurological system, suggesting that understanding miRNA-mediated mechanisms during exercise may offer valuable insights into [...] Read more.
Physical exercise induces epigenetic modifications that significantly influence the expression of a set of small non-coding RNAs known as miRNAs. These changes can enhance exercise performance and impact the neurological system, suggesting that understanding miRNA-mediated mechanisms during exercise may offer valuable insights into using exercise as a therapeutic approach for neurodegenerative diseases. The existing literature on exercise-induced molecular pathways often presents inherent biases, complicating the establishment of exercise-induced miRNAs as reliable biomarkers for various chronic conditions due to their variable expression at tissue, organ, and systemic levels. Specifically, miRNA expression can downregulate critical signaling pathways such as TGF-β, FOXO, and NOTCH, which are implicated in the progression of neurodegenerative diseases. Exercise can override this scenario by targeting the expression of these miRNAs. However, the link between exercise modality-induced benefits (types, intensity, and duration) and the miRNA expression in brain cells is poorly understood. Therefore, this review aims to discuss how exercise-mediated miRNA expression affects brain pathophysiology, particularly in the context of neurodegenerative diseases. Full article
(This article belongs to the Special Issue Redox Signaling and Oxidative Stress in Health and Disease)
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