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Biology
Special Issues
Redox Signaling and Oxidative Stress in Health and Disease
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Redox Signaling and Oxidative Stress in Health and Disease

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 2466

Special Issue Editors

Dr. Taeho Kwon

E-Mail Website
Guest Editor
Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si 56216, Jeonbuk, Republic of Korea
Interests: advanced bioconvergence; digital biotechnology; primatology; cancer biology; cancer stem cells; neurodegenerative diseases; therapeutic approaches; bioplasma
Dr. Hu-Nan Sun

E-Mail Website
Guest Editor
College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China
Interests: fibrosis; cancer biology; stem cells; stress response; neuroscience; drug screen; cell signaling pathways; plasma medicine

Special Issue Information

Dear Colleagues,

This Special Issue addresses the impact of redox signaling and oxidative stress on health and disease. Redox signaling is a crucial mechanism for maintaining physiological balance and regulating various cellular functions, while oxidative stress arises from the imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system, closely linked to disease development. This topic plays a significant role in advanced bioconvergence, digital biotechnology, aging, cancer, cardiovascular diseases, metabolic disorders, and neurodegenerative diseases. This Special Issue will highlight the latest research on the roles of redox signaling and oxidative stress in health and various diseases, as well as new therapeutic approaches related to these processes. Researchers are invited to present their findings, ranging from basic research to clinical applications, to advance the field of redox biology and explore the potential for disease prevention and treatment.

We look forward to your interest and contributions.

Dr. Taeho Kwon
Dr. Hu-Nan Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox signaling
  • oxidative stress
  • antioxidant defense
  • cellular regulation
  • aging
  • cancer
  • cardiovascular diseases
  • neurodegenerative diseases
  • therapeutic approaches
  • digital biotechnology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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21 pages, 4435 KB  
Article
Cornelian Cherry (Cornus mas) Fruit Extract Administration in Sleep Deprived Wistar Rats—Friend or Foe?
by Vlad Sever Neculicioiu, Irina Camelia Chiș, Ioana Alina Colosi, Alexandra Sevastre-Berghian, Luminita David, Mara Muntean, Ana-Maria Vlase, Remus Moldovan, Roxana Maria Decea, Carmen Costache, Horațiu Alexandru Colosi, Dan Alexandru Toc, Şoimiţa Mihaela Suciu and Simona Clichici
Biology 2025, 14(10), 1341; https://doi.org/10.3390/biology14101341 - 1 Oct 2025
Viewed by 330
Abstract
Supplement use has increased in recent years, despite limited evidence for its broad health benefits. Furthermore, exogenous antioxidants may determine pro-oxidant effects, depending on various factors such as dose, circadian window, and presence of metal ions. Although the effects of sleep deprivation (SD) [...] Read more.
Supplement use has increased in recent years, despite limited evidence for its broad health benefits. Furthermore, exogenous antioxidants may determine pro-oxidant effects, depending on various factors such as dose, circadian window, and presence of metal ions. Although the effects of sleep deprivation (SD) on the brain are well-documented, its impact on peripheral organs remains relatively underexplored. The goal of this study was to evaluate the effects of a Cornus mas (C. mas) fruit extract on multiple peripheral sites in rats undergoing paradoxical sleep deprivation (PSD). Male Wistar rats were randomly distributed in four groups, including control, C. mas (CM), sleep deprivation (SD), and sleep deprivation and C. mas (SD+CM) (n = 7/group). Seven days of PSD were associated with ultrastructural liver injury and evidence of oxidative dysfunction in several organs: liver, kidney, spleen, and aorta. These alterations were accompanied by marked increases in the evaluated cytokines, including testicular Interleukin-1β, hepatic Interleukin-6, and aortic Interleukin-4. Although the C. mas extract largely maintained hepatic ultrastructure, its effects on other organs were limited. In the aorta, it normalized GSSG values but was also associated with a significant increase in lipid peroxidation. These findings highlight both the systemic impact of SD and caution against assuming uniform benefits of exogenous antioxidants across organ systems in this context. Full article
(This article belongs to the Special Issue Redox Signaling and Oxidative Stress in Health and Disease)
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Review

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19 pages, 1223 KB  
Review
Effect of Exercise on Regulating miRNA Expression in Brain Health and Diseases
by Jian Zhang, Fengmei Gu and Anand Thirupathi
Biology 2025, 14(6), 729; https://doi.org/10.3390/biology14060729 - 19 Jun 2025
Viewed by 1274
Abstract
Physical exercise induces epigenetic modifications that significantly influence the expression of a set of small non-coding RNAs known as miRNAs. These changes can enhance exercise performance and impact the neurological system, suggesting that understanding miRNA-mediated mechanisms during exercise may offer valuable insights into [...] Read more.
Physical exercise induces epigenetic modifications that significantly influence the expression of a set of small non-coding RNAs known as miRNAs. These changes can enhance exercise performance and impact the neurological system, suggesting that understanding miRNA-mediated mechanisms during exercise may offer valuable insights into using exercise as a therapeutic approach for neurodegenerative diseases. The existing literature on exercise-induced molecular pathways often presents inherent biases, complicating the establishment of exercise-induced miRNAs as reliable biomarkers for various chronic conditions due to their variable expression at tissue, organ, and systemic levels. Specifically, miRNA expression can downregulate critical signaling pathways such as TGF-β, FOXO, and NOTCH, which are implicated in the progression of neurodegenerative diseases. Exercise can override this scenario by targeting the expression of these miRNAs. However, the link between exercise modality-induced benefits (types, intensity, and duration) and the miRNA expression in brain cells is poorly understood. Therefore, this review aims to discuss how exercise-mediated miRNA expression affects brain pathophysiology, particularly in the context of neurodegenerative diseases. Full article
(This article belongs to the Special Issue Redox Signaling and Oxidative Stress in Health and Disease)
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