Pregnancy Health and Complications: Molecular Processes and Mechanisms
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Developmental and Reproductive Biology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 22718
Special Issue Editor
Interests: preeclampsia; inflammation; oxidative stress; ER stress, autophagy-lysosomal machinery; mitochondria; cell death; protein aggregation; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pregnancy is a complex and fascinating biological process involving a series of molecular events and intricate mechanisms. The understanding of these processes and mechanisms is essential for improving pregnancy outcomes and addressing the challenges associated with pregnancy-related complications. This Special Issue aims to provide a comprehensive platform for researchers and experts to explore the molecular aspects of pregnancy health and complications, shedding light on the underlying processes and mechanisms.
The primary objective of this Special Issue is to bring together cutting-edge research and expert perspectives to advance our understanding of the molecular processes and mechanisms involved in pregnancy health and complications. This Special Issue seeks to:
- Provide an overview of the latest research findings related to molecular processes during normal pregnancy;
- Investigate the molecular mechanisms underlying common pregnancy complications;
- Explore the emerging technologies and methodologies used to study pregnancy at the molecular level;
- Identify potential biomarkers, diagnostic tools, and therapeutic targets for the personalized management of pregnancy complications.
Suggested themes:
Molecular Adaptations in Normal Pregnancy:
- Hormonal, immunological, and metabolic changes during pregnancy;
- Maternal–fetal communication and signaling pathways;
- Epigenetic modifications and their impact on pregnancy outcomes.
Molecular Mechanisms of Pregnancy Complications:
- Preeclampsia: genetic predispositions, altered angiogenesis, and endothelial dysfunction;
- Gestational diabetes: insulin signaling, metabolic alterations, and inflammation;
- Preterm birth: inflammatory responses, cervical remodeling, and uterine contractility;
- Fetal growth restriction: placental insufficiency, nutrient transport, and fetal programming.
Emerging Technologies and Methodologies:
- Transcriptomics, proteomics, and metabolomics in pregnancy research;
- Single-cell analysis to unravel cellular heterogeneity and lineage specification;
- Computational modeling and systems biology approaches for understanding complex interactions.
Translation to Clinical Practice:
- Development of molecular biomarkers for early detection and risk prediction;
- Therapeutic targets and interventions based on molecular insights.
This Special Issue welcomes the submission of original research articles, reviews, systematic reviews, meta-analyses, and perspectives. Original research articles should present novel findings with a clear focus on molecular processes and mechanisms relevant to pregnancy health and complications. Reviews should provide comprehensive and critical assessments of the current state of knowledge in specific areas. Perspectives can offer expert opinions, highlight emerging trends, or propose future directions for research and clinical practice.
In conclusion, this Special Issue on "Pregnancy Health and Complications: Molecular Processes and Mechanisms" aims to assemble a diverse collection of articles that explore the intricate molecular landscape of pregnancy. By focusing on both normal pregnancy and complications, as well as the latest technologies and translational aspects, this Special Issue aims to foster collaboration, facilitate knowledge exchange, and ultimately contribute to improved maternal and fetal health outcomes.
Dr. Shibin Cheng
Guest Editor
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Keywords
- placenta
- uterine
- fetus
- adverse pregnancy outcome
- preterm birth
- preeclampsia
- gestational diabetes
- maternal–fetal interface
- immune tolerance
- inflammation
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