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Biology, Volume 13, Issue 3

March 2024 - 69 articles

Cover Story: The COVID-19 pandemic showcases the impact of global mitigation efforts, including that of vaccine development. Nevertheless, rapid viral mutations present a challenge to disease control strategies worldwide. The experimental acquisition of mutant structures cannot match the rate at which the virus evolves. Here, we use AlphaFold2 to model SARS-CoV-2 spike protein structures for various haplotypes that remain unexplored. This AI tool delivers near-experimental resolution models in only a few hours. We compare major Variants of Concern (Alpha, Delta, and Omicron) and latitude-delimited haplotypes to the Wuhan strain. Structural changes from seasonal haplotype diversification aid in predicting virus evolution, understanding seasonal behavior, and enhancing vaccine and drug development strategies. View this paper
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Articles (69)

  • Article
  • Open Access
1 Citations
3,274 Views
14 Pages

Amorphous Calcium Carbonate from Plants Can Promote Bone Growth in Growing Rats

  • Chun-Kai Chen,
  • Yu-Shan Lee,
  • Zwe-Ling Kong and
  • Yi-Wen Chien

21 March 2024

Objectives: This study aimed to investigate the effect of amorphous calcium carbonate (ACC) supplementation on bone growth in growing rats. Methods: We used 3-week-old male Wistar rats to simulate childhood and adolescent growth stages. Rats were div...

  • Review
  • Open Access
2 Citations
4,380 Views
21 Pages

21 March 2024

Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like struct...

  • Review
  • Open Access
41 Citations
13,769 Views
19 Pages

Advances in the Development of Biofertilizers and Biostimulants from Microalgae

  • Alejandra M. Miranda,
  • Fabian Hernandez-Tenorio,
  • Fabian Villalta,
  • Gabriel J. Vargas and
  • Alex A. Sáez

21 March 2024

Microalgae have commercial potential in different sectors of the industry. Specifically in modern agriculture, they can be used because they have the ability to supply nutrients to the soil and produce plant growth hormones, polysaccharides, antimicr...

  • Article
  • Open Access
14 Citations
3,526 Views
17 Pages

20 March 2024

The hispid hare, Caprolagus hispidus, belonging to the family Leporidae is a small grassland mammal found in the southern foothills of the Himalayas, in India, Nepal, and Bhutan. Despite having an endangered status according to the IUCN Red List, it...

  • Article
  • Open Access
4 Citations
2,747 Views
17 Pages

Transcriptomic and Metabolomic Analyses Reveal the Response Mechanism of Ophiopogon japonicus to Waterlogging Stress

  • Tingting Cheng,
  • Xia Zhou,
  • Juan Lin,
  • Xianjian Zhou,
  • Hongsu Wang and
  • Tiezhu Chen

20 March 2024

Ophiopogon japonicus, a plant that thrives in river alluvial dams, often faces waterlogging stress due to sustained rainfall and flood seasons, which significantly impacts its growth and development. Currently, the mechanisms of waterlogging toleranc...

  • Article
  • Open Access
4 Citations
3,210 Views
13 Pages

Engineering a Dual Specificity γδ T-Cell Receptor for Cancer Immunotherapy

  • David M. Davies,
  • Giuseppe Pugliese,
  • Ana C. Parente Pereira,
  • Lynsey M. Whilding,
  • Daniel Larcombe-Young and
  • John Maher

20 March 2024

γδ T-cells provide immune surveillance against cancer, straddling both innate and adaptive immunity. G115 is a clonal γδ T-cell receptor (TCR) of the Vγ9Vδ2 subtype which can confer responsiveness to phosphoantigen...

  • Review
  • Open Access
1 Citations
2,519 Views
14 Pages

Bibliometric Overview on T-Cell Intracellular Antigens and Their Pathological Implications

  • Beatriz Ramos-Velasco,
  • Rocío Naranjo and
  • José M. Izquierdo

19 March 2024

T-cell intracellular antigen 1 (TIA1) and TIA1-like/related protein (TIAL1/TIAR) are two members of the classical family of RNA binding proteins. Through their selective interactions with distinct RNAs and proteins, these multifunctional regulators a...

  • Article
  • Open Access
6 Citations
2,230 Views
16 Pages

The Response of Endogenous ABA and Soluble Sugars of Platycladus orientalis to Drought and Post-Drought Rehydration

  • Na Zhao,
  • Jiahui Zhao,
  • Shaoning Li,
  • Bin Li,
  • Jiankui Lv,
  • Xin Gao,
  • Xiaotian Xu and
  • Shaowei Lu

19 March 2024

To uncover the internal mechanisms of various drought stress intensities affecting the soluble sugar content in organs and its regulation by endogenous abscisic acid (ABA), we selected the saplings of Platycladus orientalis, a typical tree species in...

  • Article
  • Open Access
3 Citations
2,071 Views
14 Pages

17 March 2024

This study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the “survival of the flattest” (SoF) fitness landscape. By simulating...

  • Article
  • Open Access
2 Citations
3,096 Views
14 Pages

Estrogen and Progesterone Receptors Are Dysregulated at the BPH/5 Mouse Preeclamptic-Like Maternal–Fetal Interface

  • Viviane C. L. Gomes,
  • Bryce M. Gilbert,
  • Carolina Bernal,
  • Kassandra R. Crissman and
  • Jenny L. Sones

16 March 2024

The etiopathogenesis of preeclampsia, a leading hypertensive disorder of pregnancy, has been proposed to involve an abnormal circulating sex hormone profile and misexpression of placental estrogen and progesterone receptors (ER and PR, respectively)....

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Biology - ISSN 2079-7737