2025 February - 62 articles
Cell sorting plays a crucial role in both medical and biological research. As a key passive sorting technique in the field of microfluidics, deterministic lateral displacement (DLD) has been widely applied to cell separation and sorting. This review...
A high-precision biosensor technique is introduced, offering the capability to independently evaluate the effects of anti-cancer drugs on both cancerous (RAJI) and non-cancerous (WIL2S) cells. By analyzing and fitting current change curves and transf...
The operating principle of a fuel cell is attracting increasing attention in the development of self-powered electrochemical sensors (SPESs). In this type of sensor, the chemical energy of the analyzed substance is converted into electrical energy in...
Malaria, an infectious disease caused by parasites of the genus Plasmodium—including the most lethal species, Plasmodium falciparum—alters the physicochemical properties of host red blood cells, including their intrinsic autofluorescence...
Flexible pressure sensors have drawn growing attention in areas like human physiological signal monitoring and human–computer interaction. Nevertheless, it still remains a significant challenge to guarantee their long-term stability while attai...
A personal glucose meter (PGM) is a medical device that measures blood glucose levels and can be found worldwide. Owing to their sensitivity, simplicity, portability, and low cost, PGMs stand as one of the most frequently utilized analytical methods....
Aptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to th...
This review into recent advancements in silicon-based technology, with a particular emphasis on the biomedical applications of silicon sensors. Owing to their diminutive size, high sensitivity, and intrinsic compatibility with electronic systems, sil...
Acetylcholinesterase inhibitors (AChEIs), particularly donepezil, are commonly used to treat mild-to-moderate Alzheimer’s disease (AD). However, drug accumulation during long-term use could change AChE activity and content, leading to periphera...
This paper explores the progressive era of sleep monitoring, focusing on wearable and remote devices contributing to advances in the concept of home polysomnography. We begin by exploring the basic physiology of sleep, establishing a theoretical basi...
Magnetic nanoparticles are extensively utilized as markers/signal labelling in various biomedical applications. Detecting and distinguishing magnetic signals from similarly sized moving magnetic nanoparticles in microfluidic systems is crucial yet ch...
Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful noninvasive analytical technique with widespread applications in biochemical analysis and biomedical diagnostics. The need for highly sensitive, reproducible, and efficient detectio...
The development of a robust and biocompatible pH-sensing platform is critical for monitoring intracellular processes and diagnosing diseases. Here, we present a smart ultrastable ratiometric fluorescence nano pH sensor based on silica-coated liposome...
Microfluidics has significantly advanced the field of single-cell analysis, particularly in studies related to cell growth, division, and heterogeneity. Electrical impedance spectroscopy (EIS), a label-free and non-invasive biosensing technique, has...
Antimicrobial resistance (AMR) is a rapidly growing global concern resulting from the overuse of antibiotics in agricultural and clinical settings. The challenge is exacerbated by the lack of rapid surveillance for resistant bacteria in clinical, env...
This review attempts to summarize my three decades-long involvement in, and contribution to, the design, construction and testing of bioluminescent microbial sensor strains (bioreporters). With the understanding that such a document cannot be complet...
An effective and highly accurate strabismus screening method is expected to identify potential patients and provide timely treatment to prevent further deterioration, such as amblyopia and even permanent vision loss. To satisfy this need, this work s...
A textile electrochemical sensor manufactured with commercially available textile materials is presented to determine glucose concentration. The sensor design consists of three electrodes manufactured with two different conductive yarns, one made wit...
We developed a mass-producible microfluidic device capable of long-term observations of single bacilli and bulk bacteria culture interactions for subsequent antimicrobial resistance (AMR) studies. The device provides high consistency across separate...
MXene is a new family of two-dimensional nanomaterials with outstanding electrical conductivity, tunable structure, biocompatibility, and a large surface area. Thanks to these unique physicochemical properties, MXene has been used for constructing el...
Malaria is a tropical disease caused by the Plasmodium parasite, which was responsible for 249 million cases worldwide in 2022. Malaria is currently diagnosed using RDTs, PCR-based methods, or blood smear microscopy. Ideal biomarkers have been identi...
Carbon dots (CDs) derived from biomass are promising fluorescent probes for specific analyte detection due to their specificity, biocompatibility, selectivity, and sensitivity. In this work, carbon dots were prepared hydrothermally from natural mater...
A microfluidic system for detecting sodium ions (Na+) has been developed, incorporating a micro finger-pump chip and a micro-spectrometer platform to measure Na+ concentration in human serum. A small volume (10 μL) of serum sample is introduced in...
Recent advances in the clinical extracellular vesicles (EVs) field highlight their potential as biomarkers for diverse diseases and therapeutic applications. This study provides an in-depth characterization of 10k EVs from human microvascular endothe...
Monitoring and assessing the progression of symptoms in neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are critical for improving patient outcomes. Traditional biomarkers, such as cerebrospinal fluid analysis a...
Tetracyclines (TCs) are antibiotics used extensively in medicine, veterinary science, and animal husbandry. Their overuse and the widespread presence of their residues in the environment contribute to intensifying the phenomenon of antibiotic resista...
Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales and brain regions. Microelectrode arrays (MEAs) are widely used to record neurophysiological activity across various...
Carbon quantum dots (CQDs), a new class of carbon-based nanomaterials, have emerged as nano-scaled probes with photoluminescence that have an eco-friendly and bio-compatible nature. Their cost-efficient synthesis and high photoluminescence quantum yi...
This study aimed to evaluate the effectiveness of two intracanal medications in promoting periapical bone healing following endodontic treatment using radiomics-enabled texture analysis of cone-beam computed tomography (CBCT) images as a novel biosen...
Fluorescence enhancement technologies play a crucial role in biological and chemical sensors. Currently, effective fluorescence sensors primarily rely on noble metals and high-index dielectric nanostructures. While effective, they are plagued by opti...
A novel strategy for the qualitative analysis of carbohydrates is developed, utilizing a direct catalytic fuel cell (DCFC) as a sensor, combined with chemometric tools for processing the resulting response curves. Specifically, carbohydrate solutions...
Fluorescence-guided surgery (FGS) is an innovative technique for accurately localizing tumors during surgery, particularly valuable in brain tumor detection. FGS uses advanced spectral and imaging tools to provide precise, quantitative fluorescence m...
Efficient separation of blood plasma and Packed Cell Volume (PCV) is vital for rapid blood sensing and early disease detection, especially in point-of-care and resource-limited environments. Conventional centrifugation methods for separation are reso...
Industrially applied bioelectrochemical systems require long-term stable operation, and hence the control of biofilm accumulation on the electrodes. An optimized application of biofilm control mechanisms presupposes on-line, in-situ monitoring of the...
From learning environments to battlefields to marketing teams, the desire to measure cognition and cognitive fatigue in real time has been a grand challenge in optimizing human performance. Near-infrared spectroscopy (NIRS) is an effective optical te...
Cancer metastasis is the leading cause of cancer-related deaths, with the ability of cancer cells to invade blood vessels or lymphatic systems, determining their metastatic potential. Therefore, the rapid and accurate assessment of cell invasiveness...
A Mach–Zehnder interferometer-based tapered-in-tapered fiber-optic biosensor was introduced in this paper. By integrating a micro-tapered fiber into a single tapered fiber structure, the design enhances sensitivity, signal-to-noise ratio, and r...
Surface acoustic wave (SAW) sensor technology is a promising approach to diagnosing cancer through the detection of cancer biomarkers due to its high sensitivity, potential label-free operation, and fast response times, and, fundamentally, because it...
Carbon nanotubes (CNTs) are widely used in electrochemical sensors due to their significant impact on the electroanalytical signal. However, there remain significant doubts regarding the origin of the improved electroanalytical response observed in C...
Free divers are known to experience a physiological response during extreme breath holding, causing involuntary breathing movements (IBMs). To investigate these movements, a low-cost multi-core ESP32-Pico microcontroller prototype was developed to me...
The performance development of rGO-FET biosensors by analyzing the influence of GO flake size on biosensing efficacy. GO flakes of varying sizes, from 1 µm to 20 µm, were prepared under controlled conditions, followed by characterization...
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder and a significant cause of dementia in elderly individuals, with a growing prevalence in our aging population. Extracellular amyloid-β peptides (Aβ), intracellular tau...
Repetitive lifting tasks in occupational settings often result in shoulder injuries, impacting both health and productivity. Accurately assessing the biomechanical risk of these tasks remains a significant challenge in occupational ergonomics, partic...
Musculoskeletal injuries induced by high-intensity and repetitive physical activities represent one of the primary health concerns in the fields of public fitness and sports. Musculoskeletal injuries, often resulting from unscientific training practi...
(1) Background: Colorectal cancer is one of the leading causes of cancer-related death, while early detection decreases incidence and mortality. Current screening programs involving fecal immunological testing and colonoscopy commonly bring about unn...
Glycine is an essential amino acid involved in synthesizing a variety of important biomolecules, and its concentration can influence numerous biochemical processes, including the severity of symptoms in a wide range of conditions in humans, such as c...
Detecting multiple tumor markers is of great importance. It helps in early cancer detection, accurate diagnosis, and monitoring treatment. In this work, gold nanoparticles–toluidine blue–graphene oxide (AuNPs-TB–GO) and gold nanopar...
Polarization light microscopy (PLM) enables detailed examination of birefringent materials and reveals unique features that cannot be observed under non-polarized light. Implementation of this technique for quantitative PLM (QPLM) assessment of sampl...
Prolonged exposure to cold air can impair reaction time and cognitive function, which can lead to serious consequences. One mitigation strategy is to develop models that can predict cognitive performance by tracking physiological metrics associated w...
Electrochemical enzyme biosensors are extensively utilized in clinical analysis and environmental monitoring, yet achieving effective enzyme immobilization while maintaining high activity remains a challenge. In this work, we developed a flow-through...
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